Results 171 to 180 of about 6,381 (215)

The oxazolidinones

Current Infectious Disease Reports, 2002
The need for effective antibiotics to manage the ever increasing frequency of antibiotic-resistant gram-positive infections in much of the developed world has led to the clinical development of the first oxazolidinone antibiotic, linezolid. Linezolid possesses bacteriostatic activity against both antibiotic-susceptible and resistant strains of ...
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New oxazolidinones

Current Opinion in Microbiology, 2007
Due to the emergence of resistance to known antibiotics to various organisms, for example, Staphylococcus, Streptococcus, Enterococci, and Pseudomonas there is a renewed interest in the discovery of new antibacterials. Oxazolidinones, totally synthetic class of novel antibacterials, possess activity against drug-resistant Gram-positive pathogens ...
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Synthesis of the oxazolidinone fragment of thelepamide

Natural Product Research, 2020
Thelepamide, an unique ketide-amino acid isolated from a marine annelid worm Thelepus crispus, has a unique oxazolidinone ring derived from cysteine, glycine and valine. Rareness in nature as well as promising bioactive possibility make the oxazolidinone ring an attractive synthetic target. The hydroxy oxazolidinone fragment of thelepamide was prepared
Naoki Ashida, Kousuke Ida, Yumi Koide, Christopher J. Vavricka, Minoru Izumi, Hiromasa Kiyota   +5 more
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Oxazolidinones: a novel class of antibiotics

Cellular and Molecular Life Sciences (CMLS), 1999
Oxazolidinones are a novel class of synthetic antimicrobial agents which have now entered phase III clinical trials. The most promising feature of these compounds is their oral activity against multidrug-resistant Gram-positive bacteria which have created tremendous therapeutic problems in recent years.
M, Müller, K L, Schimz
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Oxazolidinones: New antibacterial agents

Trends in Microbiology, 1997
The oxazolidinones are a new chemical class of synthetic antibacterial agents that are active orally or intravenously against multidrug-resistant Gram-positive bacteria. Their unique mechanism of action and activity against bacteria that pose therapeutic problems in hospital and community treatments make them promising candidates for antimicrobial ...
C W, Ford, J C, Hamel, D, Stapert, J K, Moerman, D K, Hutchinson, M R, Barbachyn, G E, Zurenko   +6 more
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Tedizolid: A new oxazolidinone antimicrobial

American Journal of Health-System Pharmacy, 2014
The mechanism of action, pharmacokinetics, pharmacodynamics, and clinical efficacy and safety of an investigational second-generation oxazolidinone are reviewed.Tedizolid is a protein synthesis inhibitor in clinical development for the treatment of gram-positive infections.
Kisgen, Jamie J., Mansour, Hanine, Unger, Nathan R., Childs, Lindsay M   +3 more
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Oxazolidinones: a new class of antibacterials

Current Opinion in Pharmacology, 2001
The oxazolidinones represent the first truly new class of antibacterial agents to reach the marketplace in several decades. They have a unique mechanism of action involving inhibition of the initiation step of protein synthesis and are not cross-resistant to other classes of antibiotics. The first marketed member of that class, linezolid (Zyvox), shows
G E, Zurenko, J K, Gibson, D L, Shinabarger, P A, Aristoff, C W, Ford, W G, Tarpley   +5 more
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Linezolid: an oxazolidinone antimicrobial agent

Clinical Therapeutics, 2001
Linezolid is the first oxazolidinone anti-infective agent marketed in the United States. It is indicated for the treatment of nosocomial pneumonia, complicated skin and skin-structure infections caused by methicillin-sensitive or methicillin-resistant Staphylococcus aureus and other susceptible organisms, and vancomycin-resistant Enterococcus faecium ...
H B, Fung, H L, Kirschenbaum, B O, Ojofeitimi   +2 more
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The oxazolidinones: past, present, and future

Annals of the New York Academy of Sciences, 2011
The success of linezolid stimulated significant efforts to discover new agents in the oxazolidinone class. Over a dozen oxazolidinones have reached the clinic, but many were discontinued due to lack of differentiated potency, inadequate pharmacokinetics, and safety risks that included myelosuppression.
Karen Joy, Shaw, Michael R, Barbachyn
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Antimycobacterial Activities of Oxazolidinones: A Review

Infectious Disorders - Drug Targets, 2006
Oxazolidinones are a new class of totally synthetic antibacterial agents with wide spectrum of activity against a variety of clinically significant susceptible and resistant bacteria. These compounds have been shown to inhibit translation at the initiation phase of protein synthesis.
R, Sood, T, Bhadauriya, M, Rao, R, Gautam, S, Malhotra, T K, Barman, D J, Upadhyay, A, Rattan   +7 more
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