Results 51 to 60 of about 913 (183)

Racemisation of Amino Acids: From Synthetic Challenge to Biological Significance

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
Racemisation, once considered an undesirable synthetic side reaction, also occurs naturally in amino acids and influences biological processes. Evidence links stereochemical conversion to ageing, protein turnover, and cellular development. This review examines mechanisms, control strategies in synthesis, applications and implications in physiology ...
Othman Al Musaimi
wiley   +1 more source

Oxazolones. Part VI. Reaction of 5(4H)-oxazolones with nitrile imines: Synthesis of 1H-1,2,4-triazoles through [3+2] cycloaddition

, 1992
5(4H)-Oxazolones (1) react as dipolarophiles in [3+2] cycloadditions with nitrile imines generated from tetrazoles (2) in refluxing anisole affording two 1H-1,2,4-triazole derivatives (3) and diarylethylenes (4 ...
R. Riva, M.L. Gelmi, D. Pocar
core   +1 more source

Alkylation of oxazolones and related heterocycles through an SN1 reaction. [PDF]

, 2011
The alkylation of oxazolones through an SN1 reaction by using stabilized carbocations is reported. The reaction (catalyzed by Brønsted acids, such as TFA or thioureas) affords the final compounds in excellent yields.
Font Bardia, Ma. Mercedes, Albert Moyano, Ríos Torres, Ramón, Andrea-Nekane R. Alba, Moyano, Albert, Teresa Calbet, Mercé Font-Bardía, Calbet, Teresa, Alba, Andrea-Nekane R., Font-Bardía, Mercé, Moyano i Baldoire, Albert, Calvet Pallàs, Maria Teresa, Ramon Rios, Rios, Ramon   +13 more
core   +1 more source

A Short Synthesis of Cyclo(‐RGDfK) Using a Microflow Reactor

ChemistryEurope, Volume 4, Issue 6, June 2026.
An efficient synthesis of cyclo(‐RGDfK) was achieved by combining a one‐flow three‐component coupling (3CC) reaction via α‐amino acid N‐carboxy anhydrides with rapid macrolactamization using a microflow reactor. Precise control of the water content and base loading in the 3CC reaction enabled the gram‐scale synthesis of the desired tripeptides and ...
Naoto Yamasaki, Mina Kim, Kana Miyamoto, Yuma Otake, Kyohei Adachi, Daisuke Kubo, Shinichiro Fuse   +6 more
wiley   +1 more source

Mesenteric Adipose Tissue as a Modulator of Intestinal Inflammation: Mechanistic Insights and Model Systems in Crohn's Disease

European Journal of Immunology, Volume 56, Issue 6, June 2026.
This review explores how mesenteric adipose tissue, particularly creeping fat, contributes to intestinal inflammation through dysregulated adipokine signalling. We explore how metabolic stress alters immune‐adipose interactions and promotes disease progression.
Toka Omar, Carl Weidinger, Britta Siegmund   +2 more
wiley   +1 more source

Synthesis and Structural Characterization of Substituted 4-Alkynyloxazolones: In Silico Insights on the Interaction with SARS-CoV-2 Spike Glycoprotein

COVID
Research on oxazolones, particularly 4-alkynyloxazolones, has garnered increasing interest due to the presence of an alkynyl group, which facilitates molecular conjugation and enables diverse chemical modifications.
Morgana Maciél Oliveira, Yuri Clemente Andrade Sokolovicz, Marieli Friedrich Loreto, Gilson Zeni, Tales A. C. Goulart, Patrick Teixeira Campos, Isabella Burchardt Ferreira, Carlos Serpa, Otávio Augusto Chaves, Davi Fernando Back   +9 more
doaj   +1 more source

The Inflammatory Response in the Murine Ovalbumin‐Induced Skin Inflammation Model Is Robust Despite Major Gut Microbiota Differences

Clinical and Translational Science, Volume 19, Issue 6, June 2026.
ABSTRACT Valid pre‐clinical animal models are essential for effective drug development in inflammatory skin diseases like atopic dermatitis. Most murine models exhibit low‐to‐moderate inflammatory responses with significant variability, undermining their validity and contributing to high drug attrition rates.
Ida Wang Henriksen, Christina Bartholdy, Janne Koch, Denitsa Vladimirova Stefanova, Camilla Hartmann Friis Hansen, Axel Kornerup Hansen   +5 more
wiley   +1 more source

Polymerization and copolymerization of 5-oxazolones

, 1983
A series of 5-oxazolones were investigated in an attempt to establish a chain-growth ring-opening polymerization of the heterocycle. The two types of 5-oxazolones studied were 2,4-disubstituted-5-oxazolones and 2-unsubstituted-5-oxazolones.
Bryant, Lonnie
core  

Intermolecular Ene Reactions Utilizing Oxazolones and Enol Ethers

, 2016
We report herein an intermolecular ene reaction using oxazolones with enol ethers which results in the formation of novel quaternary amino esters in near quantitative yields. The overall reaction transformation closely resembles an intermolecular version
Jason S. Fisk (1931746), Jetze J. Tepe (1676119)   +1 more
core   +2 more sources

Push–Pull Ynamines and Push–Pull Ynamides: Synthesis, Structure, Reactivity, and Application

European Journal of Organic Chemistry, Volume 29, Issue 19, 22 May 2026.
Push–pull ynamines and push–pull ynamides, which carry an EWG and an amino or amido group as EDG, are highly interesting classes of EDG‐EWG alkynes that have been intensively studied due to their exceptional reactivity. In this review, the synthesis, structure, reactivity, and application of push–pull ynamines, push–pull ynecarbamates, push–pull ...
Hans‐Joachim Gais
wiley   +1 more source