Results 91 to 100 of about 3,687,635 (343)
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Graphitic phosphorus coordinated single Fe atoms for hydrogenative transformations
Nature Communications, 2020 Phosphorus ligands have been extensively used in metal complexes for homogeneous catalysis. Here, the authors broaden this scope to heterogeneous catalysis by preparing a P-coordinated Fe single atom catalyst with excellent catalytic performance in ...
Xiangdong Long +8 more
doaj +1 more source
Reinforced sol–gel thermal barrier coatings and their cyclic oxidation life [PDF]
, 2013 Cyclic oxidation life enhancement of sol–gel thermal barrier coatings is obtained via the reinforcement of the controlled micro-crack network that forms during the initial sintering of the deposit.
Ansart, Florence +5 more
core +3 more sources
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Malaria Journal, 2020 Background Gold standard microscopic examination of Plasmodium falciparum intraerythrocytic stage remains an important process for staging and enumerating parasitized erythrocytes in culture; however, microscopy is laborious and its accuracy is dependent
Kasem Kulkeaw +3 more
doaj +1 more source
Improving oxidation resistance of carbon nanotube nanocomposites for aerospace applications [PDF]
, 2012 Carbon nanotubes (CNTs) based materials possess strong potential to substitute various functional materials developed exclusively for aerospace applications.
Inam, Fawad, Kumara, Saman, Vo, Thuc
core +1 more source
The pio Operon Is Essential for Phototrophic Fe(II) Oxidation in Rhodopseudomonas palustris TIE-1 [PDF]
, 2006 Phototrophic Fe(II)-oxidizing bacteria couple the oxidation of ferrous iron [Fe(II)] to reductive CO2 fixation by using light energy, but until recently, little has been understood about the molecular basis for this process. Here we report the discovery,
Jiao, Yongqin, Newman, Dianne K.
core +4 more sources
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
FERROCENYL ALKYLAMMONIUM N-SUBSTITUTED POLYPYRROLE CONTAINING Pt AND Pd AND ITS APPLICATION ON ELECTROANALYSIS OF ARSENITE [PDF]
, 2016 Indexación: Web of Science; Scopus; Scielo.Arsenic occurs in a variety of forms and oxidation states and is a very toxic element. The main inorganic arsenic species present in natural waters are arsenate (oxidation state V) and arsenite ions (oxidation ...
Moutet, JC +3 more
core +1 more source