Results 31 to 40 of about 861,618 (249)

A workplace intervention to reduce alcohol and drug consumption: a nonrandomized single-group study

BMC Public Health, 2018
Background The consumption of alcohol and other drugs causes social and health problems in industrialized societies. Furthermore, alcohol and drug consumption in the workplace is associated with work accidents, absenteeism and low productivity.
Montse Gómez-Recasens, Silvana Alfaro-Barrio, Lucia Tarro, Elisabet Llauradó, Rosa Solà   +4 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Performance of Copper as a Catalyst for Fenton-like Processes in Highly Saline Solutions

Molecules
The catalytic performance of copper in Fenton-like processes was investigated under conditions of elevated chloride concentrations. Model solutions were prepared containing four target pollutants (50 mg/L each), Cu (II) at 50 mg/L, and a stoichiometric ...
Xavier Orts, Jordi Arévalo, Antonio Arques, Ana M. Amat, Lucas Santos-Juanes   +4 more
doaj   +1 more source

Generation of human induced pluripotent stem cells (CHULAi001-A) from peripheral blood mononuclear cells of a glucose-6-phosphate dehydrogenase (G6PD) deficient subject carrying the Viangchan mutation

Stem Cell Research, 2022
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a common genetic enzyme-defect disorder. In this study, CHULAi001-A was established from peripheral blood mononuclear cells of a G6PD-deficient subject who carried the Viangchan variant (871 G > A ...
Malinee Tongbaen, Yasuko Matsumura, Keisuke Okita, Kamonlak Leecharoenkiat   +3 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The Effects of the Combination of Buckwheat D-Fagomine and Fish Omega-3 Fatty Acids on Oxidative Stress and Related Risk Factors in Pre-Obese Rats

Foods, 2021
The combined supplementation of buckwheat D-fagomine (FG) and fish omega-3 polyunsaturated fatty acids (ω-3 PUFA) attenuates the development of insulin resistance in rats fed a high-fat (HF) diet.
Bernat Miralles-Pérez, Maria Rosa Nogués, Vanessa Sánchez-Martos, Núria Taltavull, Lucía Méndez, Isabel Medina, Sara Ramos-Romero, Josep L. Torres, Marta Romeu   +8 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Participatory Research in Clinical Studies: An Innovative Approach to Co‐creating Nutritional and Physical Activity Recommendations for Older Adults With Sarcopenia (FOOP‐Sarc Project)

Health Expectations
Background Participating in co‐creation processes can improve the knowledge, satisfaction and healthcare outcomes of volunteers. However, this methodology is still underused in nutritional clinical studies. Objective This study aimed to use participatory
Maria Besora‐Moreno, Cristina Sepúlveda, Judit Queral, Claudia Jiménez‐ten Hoevel, Anna Pedret, Lucia Tarro, Rosa M. Valls, Rosa Solà, Elisabet Llauradó   +8 more
doaj   +1 more source

Effects of Oxysterols on Immune Cells and Related Diseases

Cells, 2022
Oxysterols are the products of cholesterol oxidation. They have a wide range of effects on several cells, organs, and systems in the body. Oxysterols also have an influence on the physiology of the immune system, from immune cell maturation and migration
Fábio Alessandro de Freitas, Débora Levy, Cadiele Oliana Reichert, Edecio Cunha-Neto, Jorge Kalil, Sérgio Paulo Bydlowski   +5 more
doaj   +1 more source