Results 1 to 10 of about 557,753 (336)

Targeting oxidative phosphorylation as an approach for the treatment of ovarian cancer

Frontiers in Oncology, 2022
Ovarian cancer is an aggressive tumor that remains to be the most lethal gynecological malignancy in women. Metabolic adaptation is an emerging hallmark of tumors.
Yinjie Wu, Xuewei Zhang, Ziyi Wang, Wanzhen Zheng, Huimin Cao, Wenjing Shen   +5 more
doaj   +1 more source

LRPPRC-Driven Oxidative Phosphorylation Is Associated with Elesclomol-Induced Cuproptosis in Ovarian Cancer. [PDF]

Int J Mol Sci
Wu Y, Zhang W, Jiang S, Liu S, Su J, Sun L.   +5 more
europepmc   +3 more sources

Bioenergetic Requirements and Spatiotemporal Profile of Nerve Growth Factor Induced PI3K-Akt Signaling Along Sensory Axons

Frontiers in Molecular Neuroscience, 2021
Nerve Growth Factor (NGF) promotes the elaboration of axonal filopodia and branches through PI3K-Akt. NGF activates the TrkA receptor resulting in an initial transient high amplitude burst of PI3K-Akt signaling followed by a maintained lower steady state,
Rajiv Sainath, Gianluca Gallo, Gianluca Gallo   +2 more
doaj   +1 more source

Oxidative phosphorylation in bone cells

Bone Reports, 2023
The role of energy metabolism in bone cells is an active field of investigation. Bone cells are metabolically very active and require high levels of energy in the form of adenosine triphosphate (ATP) to support their function.
Elena Sabini, Lorenzo Arboit, Mohd Parvez Khan, Giulia Lanzolla, Ernestina Schipani   +4 more
doaj   +1 more source

Mitochondrial-Linked De Novo Pyrimidine Biosynthesis Dictates Human T-Cell Proliferation but Not Expression of Effector Molecules

Frontiers in Immunology, 2021
T-cell activation upon antigen stimulation is essential for the continuation of the adaptive immune response. Impairment of mitochondrial oxidative phosphorylation is a well-known disruptor of T-cell activation.
Marlies J. W. Peeters, Pia Aehnlich, Adriano Pizzella, Kasper Mølgaard, Tina Seremet, Özcan Met, Özcan Met, Lene Juel Rasmussen, Per thor Straten, Per thor Straten, Claus Desler   +10 more
doaj   +1 more source

Mitochondrial Oxidative Phosphorylation in Viral Infections

Viruses, 2023
Mitochondria have been identified as the “powerhouse” of the cell, generating the cellular energy, ATP, for almost seven decades. Research over time has uncovered a multifaceted role of the mitochondrion in processes such as cellular stress signaling ...
Neeraja Purandare, Esha Ghosalkar, Lawrence I. Grossman, Siddhesh Aras   +3 more
doaj   +1 more source

Reduced coupling of oxidative phosphorylation in vivo precedes electron transport chain defects due to mild oxidative stress in mice. [PDF]

PLoS ONE, 2011
Oxidative stress and mitochondrial function are at the core of many degenerative conditions. However, the interaction between oxidative stress and in vivo mitochondrial function is unclear.
Michael P Siegel, Shane E Kruse, Gary Knowels, Adam Salmon, Richard Beyer, Hui Xie, Holly Van Remmen, Steven R Smith, David J Marcinek   +8 more
doaj   +1 more source

mPTP opening differently affects electron transport chain and oxidative phosphorylation at succinate and NAD-dependent substrates oxidation in permeabilized rat hepatocytes [PDF]

The Ukrainian Biochemical Journal, 2020
Mitochondrial Ca2+ overload may trigger the opening of mitochondrial permeability transition pore (mPTP) and its prolonged activation leads to cell death. ATP synthase is considered as a possible molecular component of the pore. The aim of this study was
H. M. Mazur , V. M. Merlavsky , B. O. Manko, V. V. Manko   +3 more
doaj   +1 more source

Remodelling of the Mitochondrial Bioenergetic Pathways in Human Cultured Fibroblasts with Carbohydrates

Biology, 2023
Mitochondrial oxidative phosphorylation defects underlie many neurological and neuromuscular diseases. Patients’ primary dermal fibroblasts are one of the most commonly used in vitro models to study mitochondrial pathologies. However, fibroblasts tend to
Margherita Protasoni, Jan-Willem Taanman
doaj   +1 more source

Down syndrome is an oxidative phosphorylation disorder

Redox Biology, 2021
Down syndrome is the most common genomic disorder of intellectual disability and is caused by trisomy of chromosome 21. Several genes in this chromosome repress mitochondrial biogenesis. The goal of this study was to evaluate whether early overexpression
M. Pilar Bayona-Bafaluy, Nuria Garrido-Pérez, Patricia Meade, Eldris Iglesias, Irene Jiménez-Salvador, Julio Montoya, Carmen Martínez-Cué, Eduardo Ruiz-Pesini   +7 more
doaj   +1 more source