Results 1 to 10 of about 353,485 (258)

Oxidative Phosphorylation in Silent Pituitary Adenomas: A Multiomics Perspective [PDF]

International Journal of Endocrinology
Although the World Health Organization has clearly defined silent pituitary adenomas (SPAs) and functional adenomas (non-SPAs), the detailed biological mechanisms remain unclear.
Yuan Chen, Qiang Zhao, Xing Wang, Xinling Wang, Yanying Guo   +4 more
doaj   +2 more sources

Down syndrome is an oxidative phosphorylation disorder

Redox Biology, 2021
Down syndrome is the most common genomic disorder of intellectual disability and is caused by trisomy of chromosome 21. Several genes in this chromosome repress mitochondrial biogenesis. The goal of this study was to evaluate whether early overexpression
M. Pilar Bayona-Bafaluy, Nuria Garrido-Pérez, Patricia Meade, Eldris Iglesias, Irene Jiménez-Salvador, Julio Montoya, Carmen Martínez-Cué, Eduardo Ruiz-Pesini   +7 more
doaj   +3 more sources

Multi-Bioinformatics Approach Reveals COX5B-Mediated Modulation of Oxidative Phosphorylation and ROS Levels by Water and Ethanol Extracts of Schisandrae Fructus in SW1783 Cells [PDF]

Antioxidants
Schisandrae Fructus is a traditional medicinal herb used to suppress hyperactivity and exhibits a wide range of therapeutic effects and few side effects; however, the molecular mechanism of action engaged by the multiple compounds found within ...
Musun Park, No Soo Kim, Jin-Mu Yi, Seongwon Cha   +3 more
doaj   +2 more sources

Mitochondrial electron transport chain: Oxidative phosphorylation, oxidant production, and methods of measurement

Redox Biology, 2020
The mitochondrial electron transport chain utilizes a series of electron transfer reactions to generate cellular ATP through oxidative phosphorylation.
Deirdre Nolfi-Donegan, Andrea Braganza, Sruti Shiva   +2 more
doaj   +3 more sources

Effects of exercise training on oxidative phosphorylation-related genes in a diabetic heart via microarray analysis [PDF]

BMC Cardiovascular Disorders
Background Diabetic heart disease is marked by structural, functional, and molecular alterations in the myocardium. We investigated the effects of exercise training on oxidative phosphorylation-related genes in the diabetic heart. Methods Male mice C57BL/
Iqbal Ali Shah, Shahid Ishaq, Shin-Da Lee, Bor-Tsang Wu   +3 more
doaj   +2 more sources

Targeting oxidative phosphorylation as an approach for the treatment of ovarian cancer

Frontiers in Oncology, 2022
Ovarian cancer is an aggressive tumor that remains to be the most lethal gynecological malignancy in women. Metabolic adaptation is an emerging hallmark of tumors.
Yinjie Wu, Xuewei Zhang, Ziyi Wang, Wanzhen Zheng, Huimin Cao, Wenjing Shen   +5 more
doaj   +1 more source

Bioenergetic Requirements and Spatiotemporal Profile of Nerve Growth Factor Induced PI3K-Akt Signaling Along Sensory Axons

Frontiers in Molecular Neuroscience, 2021
Nerve Growth Factor (NGF) promotes the elaboration of axonal filopodia and branches through PI3K-Akt. NGF activates the TrkA receptor resulting in an initial transient high amplitude burst of PI3K-Akt signaling followed by a maintained lower steady state,
Rajiv Sainath, Gianluca Gallo, Gianluca Gallo   +2 more
doaj   +1 more source

Oxidative phosphorylation in bone cells

Bone Reports, 2023
The role of energy metabolism in bone cells is an active field of investigation. Bone cells are metabolically very active and require high levels of energy in the form of adenosine triphosphate (ATP) to support their function.
Elena Sabini, Lorenzo Arboit, Mohd Parvez Khan, Giulia Lanzolla, Ernestina Schipani   +4 more
doaj   +1 more source

Mitochondrial-Linked De Novo Pyrimidine Biosynthesis Dictates Human T-Cell Proliferation but Not Expression of Effector Molecules

Frontiers in Immunology, 2021
T-cell activation upon antigen stimulation is essential for the continuation of the adaptive immune response. Impairment of mitochondrial oxidative phosphorylation is a well-known disruptor of T-cell activation.
Marlies J. W. Peeters, Pia Aehnlich, Adriano Pizzella, Kasper Mølgaard, Tina Seremet, Özcan Met, Özcan Met, Lene Juel Rasmussen, Per thor Straten, Per thor Straten, Claus Desler   +10 more
doaj   +1 more source

Mitochondrial Oxidative Phosphorylation in Viral Infections

Viruses, 2023
Mitochondria have been identified as the “powerhouse” of the cell, generating the cellular energy, ATP, for almost seven decades. Research over time has uncovered a multifaceted role of the mitochondrion in processes such as cellular stress signaling ...
Neeraja Purandare, Esha Ghosalkar, Lawrence I. Grossman, Siddhesh Aras   +3 more
doaj   +1 more source