Results 1 to 10 of about 3,618,892 (241)

Mitochondrial electron transport chain: Oxidative phosphorylation, oxidant production, and methods of measurement

Redox Biology, 2020
The mitochondrial electron transport chain utilizes a series of electron transfer reactions to generate cellular ATP through oxidative phosphorylation.
Deirdre Nolfi-Donegan, Andrea Braganza, Sruti Shiva   +2 more
doaj   +2 more sources

Oxidative Phosphorylation Impairment by DDT and DDE

Frontiers in Endocrinology, 2019
There is increasing evidence supporting the characterization of the pesticide DDT and its metabolite, DDE, as obesogens and metabolic disruptors. Elucidating the mechanism is critical to understanding whether the association of DDT and DDE with obesity ...
Sarah E. Elmore, Michele A. La Merrill
doaj   +2 more sources

Targeting oxidative phosphorylation as an approach for the treatment of ovarian cancer

Frontiers in Oncology, 2022
Ovarian cancer is an aggressive tumor that remains to be the most lethal gynecological malignancy in women. Metabolic adaptation is an emerging hallmark of tumors.
Yinjie Wu, Xuewei Zhang, Ziyi Wang, Wanzhen Zheng, Huimin Cao, Wenjing Shen   +5 more
doaj   +1 more source

Complex I inhibitor of oxidative phosphorylation in advanced solid tumors and acute myeloid leukemia: phase I trials

Nature Medicine, 2023
Although targeting oxidative phosphorylation (OXPHOS) is a rational anticancer strategy, clinical benefit with OXPHOS inhibitors has yet to be achieved. Here we advanced IACS-010759, a highly potent and selective small-molecule complex I inhibitor, into ...
T. Yap, N. Daver, Mikhila Mahendra, Jixiang Zhang, C. Kamiya-Matsuoka, F. Meric-Bernstam, H. Kantarjian, F. Ravandi, Meghan Collins, M. D. Francesco, E. Dumbrava, S. Fu, Sisi Gao, J. Gay, S. Gera, Jingchao Han, David S. Hong, E. Jabbour, Z. Ju, D. Karp, A. Lodi, J. Molina, Natalia Baran, A. Naing, M. Ohanian, S. Pant, N. Pemmaraju, P. Bose, S. Piha-Paul, J. Rodón, C. Salguero, K. Sasaki, A. Singh, V. Subbiah, A. Tsimberidou, Quanyu Xu, M. Yilmaz, Qi Zhang, Yuan Li, C. Bristow, M. Bhattacharjee, S. Tiziani, T. Heffernan, C. Vellano, Philip Jones, C. Heijnen, A. Kavelaars, J. Marszalek, M. Konopleva   +48 more
semanticscholar   +1 more source

Bioenergetic Requirements and Spatiotemporal Profile of Nerve Growth Factor Induced PI3K-Akt Signaling Along Sensory Axons

Frontiers in Molecular Neuroscience, 2021
Nerve Growth Factor (NGF) promotes the elaboration of axonal filopodia and branches through PI3K-Akt. NGF activates the TrkA receptor resulting in an initial transient high amplitude burst of PI3K-Akt signaling followed by a maintained lower steady state,
Rajiv Sainath, Gianluca Gallo, Gianluca Gallo   +2 more
doaj   +1 more source

Oxidative phosphorylation in bone cells

Bone Reports, 2023
The role of energy metabolism in bone cells is an active field of investigation. Bone cells are metabolically very active and require high levels of energy in the form of adenosine triphosphate (ATP) to support their function.
Elena Sabini, Lorenzo Arboit, Mohd Parvez Khan, Giulia Lanzolla, Ernestina Schipani   +4 more
doaj   +1 more source

The Effect of Oxidative Phosphorylation on Cancer Drug Resistance

Cancers, 2022
Simple Summary Drug therapy is an important treatment for cancer patients; however, drug resistance severely affects the survival time and quality of life of cancer patients.
Ziyi Zhao, Yong Mei, Ziyang Wang, Wei-ling He   +3 more
semanticscholar   +1 more source

Elevated microglial oxidative phosphorylation and phagocytosis stimulate post-stroke brain remodeling and cognitive function recovery in mice

Communications Biology, 2022
New research shows that disease-associated microglia in neurodegenerative brains present features of elevated phagocytosis, lysosomal functions, and lipid metabolism, which benefit brain repair.
Shanshan Song, Lauren Yu, Md Nabiul Hasan, S. Paruchuri, S. Mullett, M. Sullivan, Victoria M. Fiesler, C. Young, D. Stolz, S. Wendell, Dandan Sun   +10 more
semanticscholar   +1 more source

Mitochondrial-Linked De Novo Pyrimidine Biosynthesis Dictates Human T-Cell Proliferation but Not Expression of Effector Molecules

Frontiers in Immunology, 2021
T-cell activation upon antigen stimulation is essential for the continuation of the adaptive immune response. Impairment of mitochondrial oxidative phosphorylation is a well-known disruptor of T-cell activation.
Marlies J. W. Peeters, Pia Aehnlich, Adriano Pizzella, Kasper Mølgaard, Tina Seremet, Özcan Met, Özcan Met, Lene Juel Rasmussen, Per thor Straten, Per thor Straten, Claus Desler   +10 more
doaj   +1 more source

Mitochondrial Oxidative Phosphorylation in Viral Infections

Viruses, 2023
Mitochondria have been identified as the “powerhouse” of the cell, generating the cellular energy, ATP, for almost seven decades. Research over time has uncovered a multifaceted role of the mitochondrion in processes such as cellular stress signaling ...
Neeraja Purandare, Esha Ghosalkar, Lawrence I. Grossman, Siddhesh Aras   +3 more
doaj   +1 more source