Results 1 to 10 of about 3,795,946 (147)

Complex I inhibitor of oxidative phosphorylation in advanced solid tumors and acute myeloid leukemia: phase I trials

Nature Network Boston, 2023
Although targeting oxidative phosphorylation (OXPHOS) is a rational anticancer strategy, clinical benefit with OXPHOS inhibitors has yet to be achieved. Here we advanced IACS-010759, a highly potent and selective small-molecule complex I inhibitor, into ...
T. Yap, N. Daver, Mikhila Mahendra, Jixiang Zhang, C. Kamiya-Matsuoka, F. Meric-Bernstam, H. Kantarjian, F. Ravandi, Meghan Collins, M. D. Francesco, E. Dumbrava, S. Fu, Sisi Gao, J. Gay, S. Gera, Jingchao Han, David S. Hong, E. Jabbour, Z. Ju, D. Karp, A. Lodi, J. Molina, Natalia Baran, A. Naing, M. Ohanian, S. Pant, N. Pemmaraju, P. Bose, S. Piha-Paul, J. Rodón, C. Salguero, K. Sasaki, A. Singh, V. Subbiah, A. Tsimberidou, Quanyu Xu, M. Yilmaz, Qi Zhang, Yuan Li, C. Bristow, M. Bhattacharjee, S. Tiziani, T. Heffernan, C. Vellano, Philip Jones, C. Heijnen, A. Kavelaars, J. Marszalek, M. Konopleva   +48 more
semanticscholar   +1 more source

The Effect of Oxidative Phosphorylation on Cancer Drug Resistance

Cancers, 2022
Simple Summary Drug therapy is an important treatment for cancer patients; however, drug resistance severely affects the survival time and quality of life of cancer patients.
Ziyi Zhao, Yong Mei, Ziyang Wang, Wei-ling He   +3 more
semanticscholar   +1 more source

Elevated microglial oxidative phosphorylation and phagocytosis stimulate post-stroke brain remodeling and cognitive function recovery in mice

Communications Biology, 2022
New research shows that disease-associated microglia in neurodegenerative brains present features of elevated phagocytosis, lysosomal functions, and lipid metabolism, which benefit brain repair.
Shanshan Song, Lauren Yu, Md Nabiul Hasan, S. Paruchuri, S. Mullett, M. Sullivan, Victoria M. Fiesler, C. Young, D. Stolz, S. Wendell, Dandan Sun   +10 more
semanticscholar   +1 more source

Identification of a novel response regulator, Crr1, that is required for hydrogen peroxide resistance in Candida albicans [PDF]

, 2011
Peer ...
Bruce, Catherine R, da Silva Dantas, Alessandra, MacCallum, Donna M, Morgan, Brian A, Quinn, Janet, Rodgers, David, Smith, Deborah A   +6 more
core   +17 more sources

Impaired mitochondrial oxidative phosphorylation limits the self-renewal of T cells exposed to persistent antigen

Nature Immunology, 2020
The majority of tumor-infiltrating T cells exhibit a terminally exhausted phenotype, marked by a loss of self-renewal capacity. How repetitive antigenic stimulation impairs T cell self-renewal remains poorly defined.
S. Vardhana, Madeline A. Hwee, Mirela Berisa, Daniel K. Wells, K. Yost, B. King, Melody Smith, Pamela S. Herrera, Howard Y. Chang, Ansuman T. Satpathy, M. V. D. van den Brink, J. Cross, C. Thompson   +12 more
semanticscholar   +1 more source

RNAase III-Type Enzyme Dicer Regulates Mitochondrial Fatty Acid Oxidative Metabolism in Cardiac Mesenchymal Stem Cells [PDF]

, 2019
Cardiac mesenchymal stem cells (C-MSC) play a key role in maintaining normal cardiac function under physiological and pathological conditions. Glycolysis and mitochondrial oxidative phosphorylation predominately account for energy production in C-MSC ...
Jin, Yue, Kim, Il-man, Shen, Yan, Su, Xuan, Tang, Yaoliang, Weintraub, Neal L.   +5 more
core   +1 more source

Why All the Fuss about Oxidative Phosphorylation (OXPHOS)?

Journal of Medicinal Chemistry, 2020
Certain subtypes of cancer cells require oxidative phosphorylation (OXPHOS) to survive. Increased OXPHOS dependency is frequently a hallmark of cancer stem cells and cells resistant to chemotherapy and targeted therapies.
Yibin Xu, D. Xue, A. Bankhead, N. Neamati   +3 more
semanticscholar   +1 more source

A YY1-dependent increase in aerobic metabolism is indispensable for intestinal organogenesis [PDF]

, 2016
During late gestation, villi extend into the intestinal lumen to dramatically increase the surface area of the intestinal epithelium, preparing the gut for the neonatal diet.
Bonder, Edward M., Faller, William J., Gao, Nan, Gumucio, Deborah L., Joshi, Shilpy, Kumar, Namit, Perekatt, Ansu O., Sansom, Owen J., Srivillibhuthur, Manasa, Verzi, Michael P., Walton, Katherine D., White, Eileen, Xing, Jinchuan, Zhou, Anbo   +13 more
core   +1 more source

Mutant mitochondrial elongation factor G1 and combined oxidative phosphorylation deficiency [PDF]

, 2004
Although most components of the mitochondrial translation apparatus are encoded by nuclear genes, all known molecular defects associated with impaired mitochondrial translation are due to mutations in mitochondrial DNA.
Antonicka, H, Coenen, MJH, Heister, A, Newbold, RF, Rossi, R, Sasarman, F, Shoubridge, EA, Smeitink, JAM, Trijbels, FJMF, Ugalde, C, van den Heuvel, LP   +10 more
core   +4 more sources

Mitochondrial oxidative phosphorylation in cutaneous melanoma

British Journal of Cancer, 2020
The Warburg effect in tumour cells is associated with the upregulation of glycolysis to generate ATP, even under normoxic conditions and the presence of fully functioning mitochondria.
Prakrit R. Kumar, J. Moore, K. Bowles, S. Rushworth, M. Moncrieff   +4 more
semanticscholar   +1 more source