Results 11 to 20 of about 353,485 (258)

Reduced coupling of oxidative phosphorylation in vivo precedes electron transport chain defects due to mild oxidative stress in mice. [PDF]

open access: yesPLoS ONE, 2011
Oxidative stress and mitochondrial function are at the core of many degenerative conditions. However, the interaction between oxidative stress and in vivo mitochondrial function is unclear.
Michael P Siegel   +8 more
doaj   +1 more source

mPTP opening differently affects electron transport chain and oxidative phosphorylation at succinate and NAD-dependent substrates oxidation in permeabilized rat hepatocytes [PDF]

open access: yesThe Ukrainian Biochemical Journal, 2020
Mitochondrial Ca2+ overload may trigger the opening of mitochondrial permeability transition pore (mPTP) and its prolonged activation leads to cell death. ATP synthase is considered as a possible molecular component of the pore. The aim of this study was
H. M. Mazur   +3 more
doaj   +1 more source

Remodelling of the Mitochondrial Bioenergetic Pathways in Human Cultured Fibroblasts with Carbohydrates

open access: yesBiology, 2023
Mitochondrial oxidative phosphorylation defects underlie many neurological and neuromuscular diseases. Patients’ primary dermal fibroblasts are one of the most commonly used in vitro models to study mitochondrial pathologies. However, fibroblasts tend to
Margherita Protasoni, Jan-Willem Taanman
doaj   +1 more source

Oxidative Phosphorylation-Related Signature Participates in Cancer Development, and PTPRG Overexpression Suppresses the Cancer Progression in Clear Cell Renal Cell Carcinoma

open access: yesJournal of Immunology Research, 2022
Clear cell renal cell carcinoma (ccRCC) was a common cancer type diagnosed with frequent metastases, harboring an unfavorable therapeutic response, and results in a poor prognosis.
Liang Huang   +4 more
doaj   +1 more source

Low level of mancozeb exposure affects ovary in mice

open access: yesEcotoxicology and Environmental Safety, 2022
Mancozeb (MCZ) is widely used as a protective fungicide. This study aimed to explore the effects of low level MCZ exposure on ovary in mice. Twenty Kunming mice were randomly divided into control and MCZ groups (10 mice each).
Jialu Bao   +4 more
doaj   +1 more source

Progressive Upregulation of Oxidative Metabolism Facilitates Plasmablast Differentiation to a T-Independent Antigen

open access: yesCell Reports, 2018
Summary: Transitioning from a metabolically quiescent naive B cell to an antibody-secreting plasmablast requires division-dependent cellular differentiation.
Madeline J. Price   +3 more
doaj   +1 more source

MicroRNA‐661 modulates redox and metabolic homeostasis in colon cancer

open access: yesMolecular Oncology, 2017
Cancer cell survival and metastasis are dependent on metabolic reprogramming that is capable of increasing resistance to oxidative and energetic stress. Targeting these two processes can be crucial for cancer progression.
Marta Gómez de Cedrón   +8 more
doaj   +1 more source

Bioenergetics of Mycobacterium: An Emerging Landscape for Drug Discovery

open access: yesPathogens, 2018
Mycobacterium tuberculosis (Mtb) exhibits remarkable metabolic flexibility that enables it to survive a plethora of host environments during its life cycle.
Iram Khan Iqbal   +3 more
doaj   +1 more source

The First Korean case of combined oxidative phosphorylation deficiency-17 diagnosed by clinical and molecular investigation [PDF]

open access: yesKorean Journal of Pediatrics, 2017
Combined oxidative phosphorylation deficiency-17 (COXPD-17) is very rare and is caused by homozygous or compound heterozygous mutations in the ELAC2 gene on chromosome 17p12.
Young A Kim   +3 more
doaj   +1 more source

Alcohol-Induced Glycolytic Shift in Alveolar Macrophages Is Mediated by Hypoxia-Inducible Factor-1 Alpha

open access: yesFrontiers in Immunology, 2022
Excessive alcohol use increases the risk of developing respiratory infections partially due to impaired alveolar macrophage (AM) phagocytic capacity.
Niya L. Morris   +9 more
doaj   +1 more source

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