Results 211 to 220 of about 525,514 (363)

IncRNA‐ZFAS1, an Emerging Gate‐Keeper in DNA Damage‐Dependent Transcriptional Regulation

open access: yesAdvanced Science, EarlyView.
LncZFAS1 plays a crucial role during DNA damage response in mammalian cells. Loss of lncZFAS1 results in deficient DNA lesion removal and reduced cell viability. Mechanistically, lncZFAS1 modulates RNAPII phosphorylation and transcription and thereby promotes both GG‐NER and TC‐NER upon UV damage.
Jiena Liu   +10 more
wiley   +1 more source

Efficacy of novel regimens targeting oxidative phosphorylation in <i>Mycobacterium tuberculosis</i>. [PDF]

open access: yesAntimicrob Agents Chemother
Li D   +12 more
europepmc   +1 more source

Intracellular Formation of Synthetic Peptide Nanostructures Causes Mitochondrial Disruption and Cell Death in Tumor Spheroids

open access: yesAdvanced Science, EarlyView.
Synthetic peptide nanostructures, formed within cancer cells in response to glutathione, lead to mitochondrial dysfunction and cell death. The nanostructures significantly damage mitochondrial networks, impair cellular respiration, and induce cell death in both 2D cultures and 3D tumor spheroids.
Sarah Chagri   +13 more
wiley   +1 more source

Pentraxin3 exacerbates acute pancreatitis injury by inhibiting oxidative phosphorylation pathway. [PDF]

open access: yesSci Rep
Wang W   +10 more
europepmc   +1 more source

THE EFFICIENCY OF OXIDATIVE PHOSPHORYLATION IN MITOCHONDRIA FROM DIABETIC RATS

open access: hybrid, 1955
Robert E. Parks   +2 more
openalex   +1 more source

DNA‐PKcs‐Driven YAP1 Phosphorylation and Nuclear Translocation: a Key Regulator of Ferroptosis in Hyperglycemia‐Induced Cardiac Dysfunction in Type 1 Diabetes

open access: yesAdvanced Science, EarlyView.
In the context of chronic hyperglycemia, a DDR is initiated, leading to the pathological activation of DNA‐PKcs in the diabetic heart. This activated DNA‐PKcs directly interacts with and phosphorylates YAP1 at Thr226, thereby increasing the nuclear expression of YAP1.
Junyan Wang   +10 more
wiley   +1 more source

Clinical and Genetic Insights Into Combined Oxidative Phosphorylation Defect Type 38. [PDF]

open access: yesClin Case Rep
Yadav BK   +6 more
europepmc   +1 more source

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