Results 231 to 240 of about 1,214,681 (294)

AARS1‐Mediated H3K27 Lactylation Rewires Glycolysis to Sustain Aggressive and Recurrent Bladder Cancer

Advanced Science, EarlyView.
AARS1 drives PI3K–AKT–mTOR‐dependent glycolysis in bladder cancer, promoting lactate accumulation, increased lactylation, H3K27la enrichment at the HK2 promoter, and HK2 transcription. HK2 reinforces glycolysis, sustaining a metabolic–epigenetic program associated with tumor progression, recurrence, and metastasis.
Qin Yuan, Tianbao Song, Yipeng He, Sihan Xia, Yaoqiu Huang, Wenlin He, Qin Yi, Zefeng Wang, Peihan Wang, Chenbo Huang, Linzhi Li, Zhen Yin, Fan Cheng, Weimin Yu   +13 more
wiley   +1 more source

A mitochondrial function-based prognostic model for hepatocellular carcinoma uncovers MRPS15 as a key driver of tumor progression through oxidative phosphorylation. [PDF]

Transl Cancer Res
Liang W, Zhang S, Zhang Y, Sun D, Wang F, Lin H, Tian Y.   +6 more
europepmc   +1 more source

Spatiotemporal Multi‐Omic Mapping Reveals Liver‐Muscle Metabolic Crosstalk in Cancer Cachexia

Advanced Science, EarlyView.
The interactive CCAtlas platform delineates cross‐species, spatiotemporal, and sex‐specific molecular dynamics and metabolic rewiring across organs during cancer cachexia. Hepatic Gamt downregulation curtails hepatic creatine synthesis to trigger systemic creatine insufficiency and consequent skeletal muscle atrophy in LLC tumour‐bearing mice ...
Zihan Tian, Qianyu Wang, Wenyan Gao, Xianfeng Li, Jiawen Fan, Xiaoliang Wu, Siqi Liu, Xiangdong Ming, Danna Yeerken, Mutian Shen, Qingjie Min, Qimin Zhan, Yan Wang   +12 more
wiley   +1 more source

The mechanisms of energy balance between oxidative phosphorylation and glycolysis in human ovarian granulosa cells. [PDF]

Front Physiol
Wang J, Wang GJ, Wang LC, Wang LL, Qin JJ, Wang B, Cui J, Wu HL, Li R, Liu W.   +9 more
europepmc   +1 more source

YTHDC1 Orchestrates Glucose and Glutamate Rewiring to Overcome Lethal Metabolic Stress in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Lai et al. find that m6A reader YTHDC1 is specifically overexpressed in triple‐negative breast cancer (TNBC) and orchestrates glucose and glutamine metabolism in an m6A‐dependent manner to confer robust adaptability to lethal metabolic stress. Leveraging YTHDC1 knockdown‐induced metabolic vulnerability, an ATF4 mRNA‐targeted nanotherapy is developed to
Zheng‐Hao Lai, Yi Wang, Na‐Na Li, Ling Zeng, Renzhong Liu, Xue Li, Cheukfai Li, Xin‐Yu Ma, Wenkui Fu, Yingsen Tang, Jinjin Chen, Ning Liao, Man‐Li Luo   +12 more
wiley   +1 more source

A biallelic MRPL42 variant causes a combined oxidative phosphorylation deficiency syndrome revealed by multi-omics. [PDF]

NPJ Genom Med
Boschann F, Kopp J, Römer S, Küchler O, Lyubenova H, von Kügelgen N, Hertstein E, Hagelstein L, Becker C, Becker K, Brachs S, Mai K, Meierhofer D, Seelow D, Mundlos S, Horn D, Schuelke M, Fischer-Zirnsak B.   +17 more
europepmc   +1 more source

Cyclin-Dependent Kinase-9 and Oxidative Phosphorylation Inhibition Overcomes Ibrutinib Resistance in Mantle Cell Lymphoma. [PDF]

Cancer Res Commun
Roleder C, Zhao X, Lam V, Shen H, Dominguez EC, Chen C, Rodriguez-Rodriguez S, Wang L, Phillips T, Xia Z, Danilov AV.   +10 more
europepmc   +1 more source

LRPPRC-Driven Oxidative Phosphorylation Is Associated with Elesclomol-Induced Cuproptosis in Ovarian Cancer. [PDF]

Int J Mol Sci
Wu Y, Zhang W, Jiang S, Liu S, Su J, Sun L.   +5 more
europepmc   +1 more source

The Amount of Releasable Insulin Depends on Continuous Oxidative Phosphorylation. [PDF]

Function (Oxf)
Tappe C, Parambath M, Reschke J, Rustenbeck I.   +3 more
europepmc   +1 more source