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Synergistic Anti-Tumor Activity of LRPPRC Inhibition and Dasatinib Through Dual Oxidative Phosphorylation Disruption. [PDF]
Chen J +7 more
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Mitochondrial oxidative phosphorylation capacity of cryopreserved cells
Defects in mitochondrial oxidative phosphorylation are a feature of many human diseases. To date, determination of oxidative phosphorylation has required fresh and live sample material and therefore also access to specialized equipment and trained ...
Lene Juel Rasmussen, Claus Desler
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Mitochondria: beyond oxidative phosphorylation
Mitochondria are essential eukaryotic organelles that perform many functions in addition to oxidative phosphorylation. Some of these functions are still poorly understood or as yet undiscovered, but may resemble already known functions in bacteria.
Gottfried Schatz, G Schatz
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Oxidative phosphorylation and aging
Ageing Research Reviews, 2006This review addresses the data that support the presence and contribution of decreased mitochondrial oxidative phosphorylation during aging to impaired cellular metabolism. Aging impairs substrate oxidation, decreases cellular energy production and increases the production of reactive intermediates that are toxic to the cell.
Edward J Lesnefsky, Charles L Hoppel
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Mechanism of Oxidative Phosphorylation
Nature, 1958THE phenothiazine tranquillizer chlorpromazine has the following actions: (1) It inhibits electron transport between reduced diphosphopyridine nucleotide and cytochrome c in appropriate systems; the efficiency of the coupled phosphorylation is not affected. (2) Chlorpromazine is not effective in mitochondria treated with water or in non-phosphorylating
M J, DAWKINS, J D, JUDAH, K R, REES
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Non-phosphorylated intermediates in oxidative phosphorylation
Biochimica et Biophysica Acta, 1963Abstract 1. 1. This paper is concerned with the study of the formation of non-phosphorylated intermediates in digitonin particles prepared from rat-liver mitochondria. 2. 2. Digitonin particles were preincubated with either β-hydroxybutyrate, sucinate or ferrocytochrome c for a short time at 20°.
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