Results 241 to 250 of about 3,781,647 (383)

ST6GAL1‐Mediated Sialylation Stabilizes PD‐L1 and Drives Immunosuppressive Tumor Microenvironment in Colorectal Cancer

Advanced Science, EarlyView.
ST6GAL1 plays a critical role in tumor progression and immune regulation in colorectal cancer (CRC). Its depletion significantly suppresses the malignant phenotype of CRC cells and enhances the efficacy of anti‐PD‐L1 therapy. High ST6GAL1 expression promotes an immune‐activated tumor microenvironment (TME), characterized by increased infiltration of ...
Ximo Xu, Jingyi Liu, Wei Qin, Chengsheng Ding, Zhenghao Cai, Duohuo Shu, Hao Zhong, Yanyan Hu, Mengqin Yu, Leqi Zhou, Jianwen Li, Minhua Zheng, Bin Li, Sen Zhang, Xiao Yang, Bo Feng   +15 more
wiley   +1 more source

Transcriptomic Profiling of Long COVID-19 in Patients with Interstitial Lung Disease Reveals Dysregulation of Mitochondrial Oxidative Phosphorylation. [PDF]

Am J Respir Cell Mol Biol
Aracena KA, Nwankwo GC, Lee CT, Karnik R, Ventura I, Douglas D, Udofia I, Chen M, Chelala L, Im HK, Strek ME, Adegunsoye A.   +11 more
europepmc   +1 more source

CRISPR‐MI and scRNA‐Seq Reveal TREM2's Function in Monocyte Infiltration and Macrophage Apoptosis During Abdominal Aortic Aneurysm Development

Advanced Science, EarlyView.
A method is developed for conducting genome‐wide CRISPR/Cas9 screening of monocyte infiltration in vivo (CRISPR‐MI) that is easily adaptable across a variety of disease models. Through the combination of CRISPR‐MI and scRNA‐Seq, this study discovers that Trem2 is a key regulator of early monocyte infiltration in abdominal aortic aneurysm (AAA ...
Haocheng Lu, Chao Xue, Yang Zhao, Jinjian Sun, Changzhi Zhao, Xu Zhang, Guizhen Zhao, Yaozhong Liu, Hongyu Liu, Yongjie Deng, Ying Wang, Chi Zhang, Yingjie Liu, Linjun Zeng, Ying Yang, Bolun Li, Shusi Ding, Linkang Zhou, Henry Kuang, Zanxin Wang, Wenhao Ju, Haihuan Lin, Jie Lin, Yanhong Guo, Lin Chang, Hongmei Zhao, Jing Wang, Jiandie Lin, Lemin Zheng, Y. Eugene Chen, Jifeng Zhang   +30 more
wiley   +1 more source

Aetokthonotoxin, the Causative Agent of Vacuolar Myelinopathy, Uncouples Oxidative Phosphorylation due to Protonophore Activity. [PDF]

Chem Res Toxicol
Rebhahn VIC, Saoud M, Winterhalter M, Schanbacher F, Jobst M, Ruiz R, Sonntag A, Kollatz J, Sprengel R, Donovan SF, Del Favero G, Rennert R, Niedermeyer THJ.   +12 more
europepmc   +1 more source

Incorporation of amino acids into the protein of isolated mitochondria. A search for optimum conditions and a relationship to oxidative phosphorylation [PDF]

, 1962
DES TRUMAN, A. Körner
openalex   +1 more source

UCP2 Upregulates ACSL3 to Enhance Lipid Droplet Release from Acinar Cells and Modulates the Sirt1/Smad3 Pathway to Promote Macrophage‐to‐Myofibroblast Transition in Chronic Pancreatitis

Advanced Science, EarlyView.
These findings suggest that UCP2 promotes LD formation and release in acinar cells by upregulating ACSL3 expression. This alteration in the local lipid metabolic environment indirectly drives the MMT process. Additionally, UCP2 may regulate the acetylation of Smad3 through Sirt1, enhancing its nuclear activity and activating the TGF‐β/ Smad3 signaling ...
Kunpeng Wang, Lilong Zhang, Beiying Deng, Wanrong Jiang, Tianrui Kuang, Chen Chen, Kailiang Zhao, Qiao Shi, Jun He, Weixing Wang   +9 more
wiley   +1 more source

The integration of single-cell and metabolomics reveals the increase of oxidative phosphorylation during the liver metastasis of colorectal cancer. [PDF]

Cancer Metab
Liu T, Sun S, Huang Y, E Y, Li W, Xu F, Liu Z, Luo X, Lu C, Yu C.   +9 more
europepmc   +1 more source

SIZE AND SHAPE TRANSFORMATIONS CORRELATED WITH OXIDATIVE PHOSPHORYLATION IN MITOCHONDRIA [PDF]

, 1963
Lester Packer
openalex   +1 more source

Multiomics Analyses Reveal an Essential Role of Tryptophan in Treatment of csDMARDs in Rheumatoid Arthritis

Advanced Science, EarlyView.
Rheumatoid arthritis is a disease characterized by joint inflammation. Approximately 50% of patients show insufficient response to traditional synthetic disease‐modifying antirheumatic drugs. This study aims to elucidate differential molecular profiles of the mechanisms underlying drug responses through multi‐omics strategy.
Congcong Jian, Jing Zhu, Jianhong Wu, Yan Zhang, Jianghua Chen, Huan Wang, Hengyan Liu, Ke Xu, Jiaxin Huang, Xiaoting Zhu, Yuanli Wei, Shilin Li, Tingting Wang, Xuan Huang, Qinghua Zou, Jie Zhang, Jiang Su, Xinming Du, Yaping Lu, Tianci Zhou, Yingtong Zhou, Minglong Tang, Bin Li, Xue Zhou, Qihao Wei, Qiulong Yan, Fanxin Zeng   +26 more
wiley   +1 more source

PRDX6 Drives Breast Cancer Progression Through Mitochondrial Biosynthesis and Oxidative Phosphorylation. [PDF]

Cancer Med
Dai M, Zhang D.
europepmc   +1 more source