Results 21 to 30 of about 3,315,390 (285)
Cell Reports, 2018 Summary: Transitioning from a metabolically quiescent naive B cell to an antibody-secreting plasmablast requires division-dependent cellular differentiation.
Madeline J. Price +3 more
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Mitochondrial oxidative phosphorylation in cutaneous melanoma
British Journal of Cancer, 2020 The Warburg effect in tumour cells is associated with the upregulation of glycolysis to generate ATP, even under normoxic conditions and the presence of fully functioning mitochondria.
Prakrit R. Kumar +4 more
semanticscholar +1 more source
MicroRNA‐661 modulates redox and metabolic homeostasis in colon cancer
Molecular Oncology, 2017 Cancer cell survival and metastasis are dependent on metabolic reprogramming that is capable of increasing resistance to oxidative and energetic stress. Targeting these two processes can be crucial for cancer progression.
Marta Gómez de Cedrón +8 more
doaj +1 more source
Bioenergetics of Mycobacterium: An Emerging Landscape for Drug Discovery
Pathogens, 2018 Mycobacterium tuberculosis (Mtb) exhibits remarkable metabolic flexibility that enables it to survive a plethora of host environments during its life cycle.
Iram Khan Iqbal +3 more
doaj +1 more source
The First Korean case of combined oxidative phosphorylation deficiency-17 diagnosed by clinical and molecular investigation [PDF]
Korean Journal of Pediatrics, 2017 Combined oxidative phosphorylation deficiency-17 (COXPD-17) is very rare and is caused by homozygous or compound heterozygous mutations in the ELAC2 gene on chromosome 17p12.
Young A Kim +3 more
doaj +1 more source
Frontiers in Immunology, 2022 Excessive alcohol use increases the risk of developing respiratory infections partially due to impaired alveolar macrophage (AM) phagocytic capacity.
Niya L. Morris +9 more
doaj +1 more source
DN200434 Inhibits Vascular Smooth Muscle Cell Proliferation and Prevents Neointima Formation in Mice after Carotid Artery Ligation [PDF]
Endocrinology and Metabolism, 2022 Background Excessive proliferation and migration of vascular smooth muscle cells (VSMCs), which contributes to the development of occlusive vascular diseases, requires elevated mitochondrial oxidative phosphorylation to meet the increased requirements ...
Sudeep Kumar +9 more
doaj +1 more source
Rosamines targeting the cancer oxidative phosphorylation pathway. [PDF]
PLoS ONE, 2014 Reprogramming of energy metabolism is pivotal to cancer, so mitochondria are potential targets for anticancer therapy. A prior study has demonstrated the anti-proliferative activity of a new class of mitochondria-targeting rosamines.
Siang Hui Lim +5 more
doaj +1 more source
Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma
Nature, 2019 Cancer-specific inhibitors that reflect the unique metabolic needs of cancer cells are rare. Here we describe Gboxin, a small molecule that specifically inhibits the growth of primary mouse and human glioblastoma cells but not that of mouse embryonic ...
Yufeng Shi +13 more
semanticscholar +1 more source
Science Signaling, 2020 Mitochondrial Ca2+ influx promotes oxidative phosphorylation–independent pathways to enable cancer cell survival. Staying alive without oxidative phosphorylation Oxidative phosphorylation is used by many cell types to produce ATP and requires low-level ...
C. Cárdenas +20 more
semanticscholar +1 more source