Results 41 to 50 of about 3,315,390 (285)

Cancer Stem Cells in Small Cell Lung Cancer Cell Line H446: Higher Dependency on Oxidative Phosphorylation and Mitochondrial Substrate-Level Phosphorylation than Non-Stem Cancer Cells. [PDF]

PLoS ONE, 2016
Recently, targeting cancer stem cells (CSCs) metabolism is becoming a promising therapeutic approach to improve cancer treatment outcomes. However, knowledge of the metabolic state of CSCs in small cell lung cancer is still lacking.
Cuicui Gao, Yao Shen, Fang Jin, Yajing Miao, Xiaofei Qiu   +4 more
doaj   +1 more source

Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin

Nature Communications, 2018
Hepatocellular carcinoma (HCC) cells are metabolically distinct from normal hepatocytes by expressing the high-affinity hexokinase (HK2) and suppressing glucokinase (GCK). This is exploited to selectively target HCC.
Dannielle C. DeWaal, V. Nogueira, Alexander R. Terry, K. Patra, Sang-Min Jeon, G. Guzman, Jennifer T C Au, Christopher P. Long, M. Antoniewicz, N. Hay   +9 more
semanticscholar   +1 more source

Is There a Link between Mitochondrial Reserve Respiratory Capacity and Aging?

Journal of Aging Research, 2012
Oxidative phosphorylation is an indispensable resource of ATP in tissues with high requirement of energy. If the ATP demand is not met, studies suggest that this will lead to senescence and cell death in the affected tissue.
Claus Desler, Thomas Lau Hansen, Jane Bruun Frederiksen, Maiken Lise Marcker, Keshav K. Singh, Lene Juel Rasmussen   +5 more
doaj   +1 more source

Accurate determination of the oxidative phosphorylation affinity for ADP in isolated mitochondria.

PLoS ONE, 2011
BackgroundMitochondrial dysfunctions appear strongly implicated in a wide range of pathologies. Therefore, there is a growing need in the determination of the normal and pathological integrated response of oxidative phosphorylation to cellular ATP demand.
Gilles Gouspillou, Richard Rouland, Guillaume Calmettes, Véronique Deschodt-Arsac, Jean-Michel Franconi, Isabelle Bourdel-Marchasson, Philippe Diolez   +6 more
doaj   +1 more source

Bioenergetic Adaptations in Chemoresistant Ovarian Cancer Cells

Scientific Reports, 2017
Earlier investigations have revealed that tumor cells undergo metabolic reprogramming and mainly derive their cellular energy from aerobic glycolysis rather than oxidative phosphorylation even in the presence of oxygen. However, recent studies have shown
Sajad Dar, Jasdeep Chhina, Ismail Mert, Dhananjay Chitale, Thomas Buekers, Hareena Kaur, Shailendra Giri, Adnan Munkarah, Ramandeep Rattan   +8 more
doaj   +1 more source

Construction and Validation of an Oxidative Phosphorylation Signature in High-Grade Glioma and Potential Inhibitors Screening

Analytical Cellular Pathology
Glioma is a devastating type of brain tumor with high morbidity and mortality rates. Despite current treatment options, the prognosis for glioma patients remains poor.
Hanwen Lu, Wenpeng Zhao, Bingchang Zhang, Yuanyuan Xie, Jiawei He, Huiying Yang, Zhanxiang Wang   +6 more
doaj   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Increased hepatic fatty acids uptake and oxidation by LRPPRC-driven oxidative phosphorylation reduces blood lipid levels

Frontiers in Physiology, 2016
Hyperlipidemia is one of the major risk factors of atherosclerosis and other cardiovascular diseases. This study aimed to investigate the impact of leucine rich pentatricopeptide repeat containing protein (LRPPRC)-driven hepatic oxidative phoshorylation ...
Ping Zhou, Chi Wei, Xin-yan Wang, Jun-lin Li, Wei He, Mei-zhen Gong, Di Wang, Shi Lei   +7 more
doaj   +1 more source

Exploring Thermal Sensitivities and Adaptations of Oxidative Phosphorylation Pathways

Metabolites, 2022
Temperature shifts are a major challenge to animals; they drive adaptations in organisms and species, and affect all physiological functions in ectothermic organisms.
Hélène Lemieux, Pierre U. Blier
doaj   +1 more source

The role of fibroblast growth factors in cell and cancer metabolism

FEBS Letters, EarlyView.
Fibroblast growth factor (FGF) signaling regulates crucial signaling cascades that promote cell proliferation, survival, and metabolism. Therefore, FGFs and their receptors are often dysregulated in human diseases, including cancer, to sustain proliferation and rewire metabolism.
Jessica Price, Chiara Francavilla
wiley   +1 more source