Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma
Nature, 2019 Cancer-specific inhibitors that reflect the unique metabolic needs of cancer cells are rare. Here we describe Gboxin, a small molecule that specifically inhibits the growth of primary mouse and human glioblastoma cells but not that of mouse embryonic ...
Yufeng Shi +13 more
semanticscholar +1 more source
Iron-Induced Oxidative Injury Differentially Regulates PI3K/Akt/GSK3β Pathway in Synaptic Endings from Adult and Aged Rats [PDF]
, 2009 In this work we study the state of phosphoinositide-3-kinase/Akt/glycogen synthase kinase 3 beta (PI3K/Akt/GSK3 beta) signaling during oxidative injury triggered by free iron using cerebral cortex synaptic endings isolated from adult (4-month-old) and ...
Giusto, Norma Maria +2 more
core +2 more sources
A first--order irreversible thermodynamic approach to a simple energy converter
, 2007 Several authors have shown that dissipative thermal cycle models based on Finite-Time Thermodynamics exhibit loop-shaped curves of power output versus efficiency, such as it occurs with actual dissipative thermal engines.
A. L. Lehninger +16 more
core +1 more source
STAT3, a hub protein of cellular signaling pathways, is triggered by β-hexaclorocyclohexane [PDF]
, 2018 Background: Organochlorine pesticides (OCPs) are widely distributed in the environment and their toxicity is mostly associated with the molecular mechanisms of endocrine disruption.
Altieri, F +7 more
core +2 more sources
Hypoxia induces mitochondrial protein lactylation to limit oxidative phosphorylation
Cell ResearchOxidative phosphorylation (OXPHOS) consumes oxygen to produce ATP. However, the mechanism that balances OXPHOS activity and intracellular oxygen availability remains elusive.
Yun-Zi Mao +16 more
semanticscholar +1 more source
Oxidative Stress Signaling in Blast TBI-Induced Tau Phosphorylation
Antioxidants, 2021 Traumatic brain injury caused by blast is associated with long-term neuropathological changes including tau phosphorylation and pathology. In this study, we aimed to determine changes in initial tau phosphorylation after exposure to a single mild blast ...
Chunyu Wang +10 more
doaj +1 more source
Proteinopathy, oxidative stress and mitochondrial dysfunction: cross talk in alzheimer’s disease and parkinson’s disease [PDF]
, 2017 Alzheimer's disease and Parkinson's disease are two common neurodegenerative diseases of the elderly people that have devastating effects in terms of morbidity and mortality.
Chakrabarti, S. +3 more
core +3 more sources
Science Translational Medicine, 2019 Targeting oxidative phosphorylation overcomes ibrutinib resistance in mantle cell lymphoma. Dismantling lymphoma metabolism Mantle cell lymphoma is a B cell malignancy that often responds to initial treatment with ibrutinib, an inhibitor of Bruton’s ...
L. Zhang +30 more
semanticscholar +1 more source
Is There a Link between Mitochondrial Reserve Respiratory Capacity and Aging?
Journal of Aging Research, 2012 Oxidative phosphorylation is an indispensable resource of ATP in tissues with high requirement of energy. If the ATP demand is not met, studies suggest that this will lead to senescence and cell death in the affected tissue.
Claus Desler +5 more
doaj +1 more source
Cancer Stem Cells in Small Cell Lung Cancer Cell Line H446: Higher Dependency on Oxidative Phosphorylation and Mitochondrial Substrate-Level Phosphorylation than Non-Stem Cancer Cells. [PDF]
PLoS ONE, 2016 Recently, targeting cancer stem cells (CSCs) metabolism is becoming a promising therapeutic approach to improve cancer treatment outcomes. However, knowledge of the metabolic state of CSCs in small cell lung cancer is still lacking.
Cuicui Gao +4 more
doaj +1 more source