Results 71 to 80 of about 525,514 (363)

The emerging role of Nrf2 in mitochondrial function [PDF]

, 2015
The transcription factor NF-E2 p45-related factor 2 (Nrf2; gene name NFE2L2) allows adaptation and survival under conditions of stress by regulating the gene expression of diverse networks of cytoprotective proteins, including antioxidant, anti ...
Abbas, Abdullah, Agyeman, Albena T. Dinkova-Kostova, Andrey Y. Abramov, Anedda, Aoyama, Armah, Athale, Baird, Baird, Baldelli, Benedict, Brewer, Brose, Burton, Calkins, Cao, Chang, Chen, Chowdhry, Christensen, Clements, Cullinan, Dinkova-Kostova, Dinkova-Kostova, Dobrzyn, Dobrzyn, Doulias, East, Finck, Flier, Galuppo, Gan, Gao, Garcia, Giorgio, Greco, Greco, Guerrero-Beltran, Harvey, Hawkes, Hayashi, Hayes, Higgins, Holmstrom, Hu, Hurd, Im, Innamorato, Itoh, Jazwa, Kaidery, Kensler, Kim, Kim, Kim, Kim, Kitteringham, Kobayashi, Kovac, Lee, Liu, Lopez-Bernardo, Ludtmann, MacLeod, Marcotte, Maruyama, McMahon, Meakin, Miller, Mitsuishi, Moser, Negrette-Guzman, Niso-Santano, Pang, Papaiahgari, Piantadosi, Piantadosi, Rada, Rojo, Rustin, Sakurai, Sasaki, Scarpulla, Scarpulla, Scott, Shen, Singh, Smyrnias, Suh, Suzuki, Tanito, Thimmulappa, Tufi, Uruno, Ushida, Wakabayashi, Wang, Wild, Williamson, Woo, Wu, Wu, Xu, Yang, Yates, Youle, Zhang, Zhang, Zhang, Zhu   +111 more
core   +3 more sources

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

A Novel Bis-Coumarin Targets Multiple Tyrosine Kinases of Key Signaling Pathways in Melanoma and Inhibits Melanoma Cell Survival, Proliferation, and Migration [PDF]

arXiv, 2020
Melanoma is one of the most dangerous skin malignancies due to its high metastatic tendency and high mortality. Activation of key signaling pathways enforcing melanoma progression depends on phosphorylation of tyrosine kinases, and oxidative stress. We here investigated the effect of the new bis-coumarin derivative (3,5-DCPBC) on human melanoma cell ...
arxiv  

Targeting cytochrome C oxidase in mitochondria with Pt(II)-porphyrins for Photodynamic Therapy [PDF]

, 2010
Mitochondria are the power house of living cells, where the synthesis of the chemical "energy currency" adenosine triphosphate (ATP) occurs. Oxidative phosphorylation by a series of membrane protein complexes I to IV, that is, the electron transport chain, is the source of the electrochemical potential difference or proton motive force (PMF) of protons
arxiv   +1 more source

Self-Organization and Fractality in a Metabolic Process of the Krebs Cycle [PDF]

Ukr.Biochem.J. 2013; Volume 85, Issue 5, Sep-Oct, pp. 191-200, 2017
With the help of a mathematical model, the metabolic process of the Krebs cycle is studied. The autocatalytic processes resulting in both the formation of the self-organization in the Krebs cycle and the appearance of a cyclicity of its dynamics are determined.
arxiv   +1 more source

Low level of mancozeb exposure affects ovary in mice

Ecotoxicology and Environmental Safety, 2022
Mancozeb (MCZ) is widely used as a protective fungicide. This study aimed to explore the effects of low level MCZ exposure on ovary in mice. Twenty Kunming mice were randomly divided into control and MCZ groups (10 mice each).
Jialu Bao, Yan Zhang, Ran Wen, Linchao Zhang, Xiaodan Wang   +4 more
doaj  

Exploring Thermal Sensitivities and Adaptations of Oxidative Phosphorylation Pathways

Metabolites, 2022
Temperature shifts are a major challenge to animals; they drive adaptations in organisms and species, and affect all physiological functions in ectothermic organisms.
Hélène Lemieux, Pierre U. Blier
doaj   +1 more source

Role of the Intracellular pH in the Metabolic Switch between Oxidative Phosphorylation and AerobicGlycolysis - Relevance to Cancer [PDF]

, 2011
Cellular energy in the form of ATP can be produced through oxidative phosphorylation and through glycolysis. Since oxidative phosphorylation requires oxygen and generates ATP more efficiently than glycolysis, it has been assumed for many years that ...
Burgos Morón, Estefanía, Calderón Montaño, José Manuel, López Lázaro, Miguel, Pérez Guerrero, María Concepción, Robles Frías, Antonio, Salvador Bofill, Francisco Javier   +5 more
core  

The Corepressor NCoR1 Antagonizes PGC-1α and Estrogen-Related Receptor α in the Regulation of Skeletal Muscle Function and Oxidative Metabolism [PDF]

, 2012
Skeletal muscle exhibits a high plasticity and accordingly can quickly adapt to different physiological and pathological stimuli by changing its phenotype largely through diverse epigenetic mechanisms.
Pérez-Schindler, Joaquín, Summermatter, Serge, Salatino, Silvia, Zorzato, Francesco, Beer, Markus, Balwierz, Piotr J., van Nimwegen, Erik, Feige, Jérôme N., Auwerx, Johan, Handschin, Christoph   +9 more
core   +5 more sources

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source