Results 171 to 180 of about 1,592,981 (302)

Intercompartmental communication in senescence

FEBS Open Bio, EarlyView.
Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz, Eleanor J. Wind, Jixiang Leng, Myriam Gorospe   +3 more
wiley   +1 more source

Linking Transition Metal Concentration and Oxidative Potential in PM_2.5 by Ascorbic Acid Assay via Quasi-Michaelis-Menten Mechanism. [PDF]

Environ Sci Technol
Cheng Y, Chen H, Yu JZ.
europepmc   +1 more source

Particle Constituents and Oxidative Potential: Insights into Differential Fine Particulate Matter Toxicity. [PDF]

Am J Respir Crit Care Med, 2022
Rule AM, Koehler KA.
europepmc   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Short-lived reactive components substantially contribute to particulate matter oxidative potential. [PDF]

Sci Adv
Campbell SJ, Utinger B, Barth A, Leni Z, Zhang ZH, Resch J, Li K, Steimer SS, Banach C, Gfeller B, Wragg FPH, Westwood J, Wolfer K, Bukowiecki N, Ihalainen M, Yli-Pirilä P, Somero M, Kortelainen M, Louhisalmi J, Sklorz M, Czech H, di Bucchianico S, Streibel T, Delaval MN, Ruger C, Baumlin N, Salathe M, Fang Z, Pardo M, D'Aronco S, Giorio C, Shi Z, Harrison RM, Green DC, Kelly FJ, Rudich Y, Paulson SE, Sippula O, Zimmermann R, Geiser M, Kalberer M.   +40 more
europepmc   +1 more source

Iron and Copper Alter the Oxidative Potential of Secondary Organic Aerosol: Insights from Online Measurements and Model Development. [PDF]

Environ Sci Technol, 2023
Campbell SJ, Utinger B, Barth A, Paulson SE, Kalberer M.   +4 more
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Oxidative potential and persistent free radicals in dust storm particles and their associations with hospitalization. [PDF]

Nat Commun
Qin L, Yang L, Liu L, Tong S, Liu Q, Li G, Zhang H, Zhu W, Liu G, Zheng M, Jiang G.   +10 more
europepmc   +1 more source

Oxidative Potential of Metal-Containing Nanoparticles in Coal Fly Ash Generated from Coal-Fired Power Plants in China. [PDF]

Environ Health (Wash), 2023
Xu M, Niu Z, Liu C, Yan J, Peng B, Yang Y.   +5 more
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source