Results 201 to 210 of about 1,578,374 (306)

Evidence of Iron Accumulation in Cerebral Adrenoleukodystrophy: A Potential Novel Disease Mechanism

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT In this first application of Quantitative Susceptibility Mapping Source Separation to cerebral adrenoleukodystrophy, we uncovered alterations in iron and myelin within lesions and normal appearing white matter. As validation, we demonstrate abnormal iron accumulation in those same compartments within primary brain tissue.
Christina L. Nemeth, Mert Sisman, Jinwei Zhang, Hyeong‐geol Shin, Xu Li, Bela Turk, Ali Fatemi, Thanh Nguyen, Eric Mallack   +8 more
wiley   +1 more source

Assessing the Oxidative Potential of Outdoor PM_2.5 in Wintertime Fairbanks, Alaska. [PDF]

ACS EST Air
Yang Y, Battaglia MA, Mohan MK, Robinson ES, DeCarlo PF, Edwards KC, Fang T, Kapur S, Shiraiwa M, Cesler-Maloney M, Simpson WR, Campbell JR, Nenes A, Mao J, Weber RJ.   +14 more
europepmc   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Local incomplete combustion emissions define the PM_2.5 oxidative potential in Northern India. [PDF]

Nat Commun
Bhattu D, Tripathi SN, Bhowmik HS, Moschos V, Lee CP, Rauber M, Salazar G, Abbaszade G, Cui T, Slowik JG, Vats P, Mishra S, Lalchandani V, Satish R, Rai P, Casotto R, Tobler A, Kumar V, Hao Y, Qi L, Khare P, Manousakas MI, Wang Q, Han Y, Tian J, Darfeuil S, Minguillon MC, Hueglin C, Conil S, Rastogi N, Srivastava AK, Ganguly D, Bjelic S, Canonaco F, Schnelle-Kreis J, Dominutti PA, Jaffrezo JL, Szidat S, Chen Y, Cao J, Baltensperger U, Uzu G, Daellenbach KR, El Haddad I, Prévôt ASH.   +44 more
europepmc   +1 more source

Clinical Conditions Associated With a High Antinuclear Antibody Titer in Individuals Without Autoimmune Disease

Arthritis Care &Research, EarlyView.
Objective Antinuclear antibodies (ANAs) are present at high titers in 2% of the general population, but their clinical significance in individuals without an autoimmune (AI) disease is not known. We tested the hypothesis that the presence of a high ANA titer in non‐AI conditions is associated with disease.
Matthew Chung, John P. Shelley, Gul Karakoc, John Still, Xiaodi Ruan, Jonathan Mosley, C. Michael Stein, Vivian K. Kawai   +7 more
wiley   +1 more source

Can oxidative potential be a plant risk indicator for heavy metals contaminated soil? Analysis of ryegrass (<i>Lolium perenne</i> L.) metabolome based on machine learning. [PDF]

Eco Environ Health
Ran C, Guo M, Wang Y, Li Y, Wang J, Zhang Y, Liu C, Bergquist BA, Peng C.   +8 more
europepmc   +1 more source

Marked Long‐Term Improvement in Lung Function in Melanoma Differentiation–Associated Protein 5 Antibody–Positive Dermatomyositis Patients: Experience of a Single‐Center Longitudinal Cohort in North America

Arthritis Care &Research, EarlyView.
Objective The objective of this study was to describe the longitudinal disease course and pulmonary outcomes of North American patients with melanoma differentiation–associated protein 5 (MDA5) antibody–associated dermatomyositis (DM). Methods Thirty patients with MDA5 antibody–associated DM were identified in a single‐center longitudinal cohort of 352
Jenice X. Cheah, Sangmee S. Bae, Tiffany De Leon, Yuna Lee, Rong Guo, David Elashoff, Jennifer Wang, Ani Shahbazian, Christina Charles‐Schoeman   +8 more
wiley   +1 more source

Online Measurements during Simulated Atmospheric Aging Track the Strongly Increasing Oxidative Potential of Complex Combustion Aerosols Relative to Their Primary Emissions. [PDF]

Environ Sci Technol Lett
Cheung RKY, Zhang J, Wang T, Kattner L, Bogler S, Puthussery JV, Huang RJ, Gysel-Beer M, Slowik JG, Verma V, Prevot ASH, El Haddad I, Bell DM, Modini RL.   +13 more
europepmc   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Association Between Oxidative Potential of Particulate Matter Collected by Personal Samplers and Systemic Inflammation Among Asthmatic and Non-Asthmatic Adults. [PDF]

Antioxidants (Basel)
Santibáñez M, Ruiz-Cubillán JJ, Expósito A, Agüero J, García-Rivero JL, Abascal B, Amado CA, Ruiz-Azcona L, Lopez-Hoyos M, Irure J, Robles Y, Berja A, Barreiro E, Núñez-Robainas A, Cifrián JM, Fernandez-Olmo I.   +15 more
europepmc   +1 more source