Results 201 to 210 of about 1,592,981 (302)

Air Pollution and the Risk and Progression of Multiple Sclerosis: A Systematic Review and Meta‐Analysis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose Air pollution has been linked to several neurological conditions, including stroke and neurodegenerative diseases. Evidence regarding its association with multiple sclerosis (MS) remains conflicting, limited by small sample sizes. Methods PubMed, Embase, Scopus, and Cochrane controlled register of trials (CENTRAL) were searched on ...
Ahmad A. Toubasi, Thuraya N. Al‐Sayegh
wiley   +1 more source

Local incomplete combustion emissions define the PM_2.5 oxidative potential in Northern India. [PDF]

Nat Commun
Bhattu D, Tripathi SN, Bhowmik HS, Moschos V, Lee CP, Rauber M, Salazar G, Abbaszade G, Cui T, Slowik JG, Vats P, Mishra S, Lalchandani V, Satish R, Rai P, Casotto R, Tobler A, Kumar V, Hao Y, Qi L, Khare P, Manousakas MI, Wang Q, Han Y, Tian J, Darfeuil S, Minguillon MC, Hueglin C, Conil S, Rastogi N, Srivastava AK, Ganguly D, Bjelic S, Canonaco F, Schnelle-Kreis J, Dominutti PA, Jaffrezo JL, Szidat S, Chen Y, Cao J, Baltensperger U, Uzu G, Daellenbach KR, El Haddad I, Prévôt ASH.   +44 more
europepmc   +1 more source

Evidence of Iron Accumulation in Cerebral Adrenoleukodystrophy: A Potential Novel Disease Mechanism

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT In this first application of Quantitative Susceptibility Mapping Source Separation to cerebral adrenoleukodystrophy, we uncovered alterations in iron and myelin within lesions and normal appearing white matter. As validation, we demonstrate abnormal iron accumulation in those same compartments within primary brain tissue.
Christina L. Nemeth, Mert Sisman, Jinwei Zhang, Hyeong‐geol Shin, Xu Li, Bela Turk, Ali Fatemi, Thanh Nguyen, Eric Mallack   +8 more
wiley   +1 more source

Can oxidative potential be a plant risk indicator for heavy metals contaminated soil? Analysis of ryegrass (<i>Lolium perenne</i> L.) metabolome based on machine learning. [PDF]

Eco Environ Health
Ran C, Guo M, Wang Y, Li Y, Wang J, Zhang Y, Liu C, Bergquist BA, Peng C.   +8 more
europepmc   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Online Measurements during Simulated Atmospheric Aging Track the Strongly Increasing Oxidative Potential of Complex Combustion Aerosols Relative to Their Primary Emissions. [PDF]

Environ Sci Technol Lett
Cheung RKY, Zhang J, Wang T, Kattner L, Bogler S, Puthussery JV, Huang RJ, Gysel-Beer M, Slowik JG, Verma V, Prevot ASH, El Haddad I, Bell DM, Modini RL.   +13 more
europepmc   +1 more source

Relationship Between Neurologic Symptoms and Signs and FMR1 Genotype in Premutation Carriers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Fragile X‐associated Tremor/Ataxia Syndrome (FXTAS) is the most severe late‐onset condition caused by a premutation in the FMR1 gene, characterized by expanded CGG triplet repeats of 55–200. Clinical presentations of FXTAS, including gait ataxia, kinetic tremor, cognitive decline, and rare Parkinsonism, are linked to ...
Flora Tassone, Freddy Chafota, Miguel E. Rentería, Randi J. Hagerman, Ellery Santos, Anna Atkinson, Nicholas G. Martin, Elsdon Storey, Danuta Z. Loesch   +8 more
wiley   +1 more source

Association Between Oxidative Potential of Particulate Matter Collected by Personal Samplers and Systemic Inflammation Among Asthmatic and Non-Asthmatic Adults. [PDF]

Antioxidants (Basel)
Santibáñez M, Ruiz-Cubillán JJ, Expósito A, Agüero J, García-Rivero JL, Abascal B, Amado CA, Ruiz-Azcona L, Lopez-Hoyos M, Irure J, Robles Y, Berja A, Barreiro E, Núñez-Robainas A, Cifrián JM, Fernandez-Olmo I.   +15 more
europepmc   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Plasma-Activated Tap Water with Oxidative Potential Has an Inactivating Effect on Microbiological Contaminants in Aqueous Suspensions. [PDF]

Pathogens
Droste NC, Hummert M, Leenders P, Mellmann A, Becker K, Kuczius T.   +5 more
europepmc   +1 more source