Results 101 to 110 of about 1,212,238 (318)

Oxidative Stress, a Crossroad Between Rare Diseases and Neurodegeneration

, 2020
: Oxidative stress is an imbalance between production and accumulation of oxygen reactive species and/or reactive nitrogen species in cells and tissues, and the capacity of detoxifying these products, using enzymatic and non-enzymatic components, such as
Espinós, Galindo, Sevilla, Ibáñez-Cabellos, Martínez-Rubio, Pallardó, García-Gimeno, Millán, Tapia, Rodrigo, Seco-Cervera, Sanz   +11 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Circadian rhythms of antioxidant enzymes activity, clock, and inflammation factors are disrupted in the prefrontal cortex of aged rats. Potential targets for therapeutic strategies for a healthy aging.

Age impairs cognitive functions and antioxidant defenses, for example, by increasing oxidative stress and inflammation in the brain. However, so far, there is no report on the consequences of aging on temporal patterns of proteins and lipids oxidation ...
Ponce, Ivana, Ramírez, Darío, Lacoste, María Gabriela, Gómez-mejiba, Sandra, Delgado, Silvia Marcela, Anzulovich, Ana, Della Vedova, María Cecilia, Coria-lucero, Cinthia, Devia, Cristina   +8 more
core   +1 more source

Oxidative stress, Chinese herbals and toxicity: A focused review with examples

, 2020
As a double-edged sword, reactive oxygen species (ROS) are extensively involved in the modulation of cell signal transduction in life processes with normal physiological concentrations, whereas overproduction of ROS can result in oxidative stress ...
ZHANG, C, Yibin Feng, Cheng Zhang, Wang, N, Feng, Y, Zhang, Cheng, Wang, Ning, Feng, Yibin, Ning Wang   +8 more
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Food Neophobias in Spanish Adults with Overweight or Obesity by Sex: Their Association with Sociodemographic Factors and the Most Prevalent Chronic Diseases

Foods
Food neophobia has been defined as the reluctance to try new foods. Food neophobia is common in children and older people, but until now, scarce research has been carried out on food neophobia in the adult population.
Carmen del Campo, Cristina Bouzas, Margalida Monserrat-Mesquida, Josep A. Tur   +3 more
doaj   +1 more source

Body image satisfaction and weight concerns among a Mediterranean adult population

BMC Public Health, 2017
Background People tend to underestimate their current weight and overestimate their height minimizing health risk factors. The aim of this study was to assess body weight satisfaction, acceptance of body image, weight concern and dieting habits among a ...
Maria del Mar Bibiloni, Josep Ll Coll, Jordi Pich, Antoni Pons, Josep A. Tur   +4 more
doaj   +1 more source

Implications for oxidative stress and astrocytes following 26S proteasomal depletion in mouse forebrain neurones

, 2013
Neurodegenerative diseases are characterized by progressive degeneration of selective neurones in the nervous system, but the underlying mechanisms involved in neuroprotection and neurodegeneration remain unclear.
Elkharaz, J, Billett, E, Ugun-Klusek, Aslihan, Bedford, L, Bedford, Lynn, Mayer, R John, Lowe, James, Mayer, RJ, Elkharaz, Jamal, Billett, Ellen, Lawler, K, Lawler, Karen, Ugun-Klusek, A, Lowe, J, Constantin-Teodosiu, D, Constantin-Teodosiu, Dumitru   +15 more
core   +1 more source

Oxidative Stress in Preterm Newborns

, 2021
Preterm babies are highly susceptible to oxidative stress (OS) due to an imbalance between the oxidant and antioxidant systems. The generation of free radicals (FR) induces oxidative damage to multiple body organs and systems.
Serafina Perrone, Chiara Lembo, Giuseppe Buonocore   +2 more
core   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source