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Lipids in Health and Disease, 2020 Background Lipid-lowering therapy is guided by Low-density-lipoprotein cholesterol (LDL-c) levels, although the cardiovascular disease (CVD) risk could be better reflected by other lipid parameters.
Liliana Fonseca +4 more
doaj +1 more source
Carbamylated-oxidized LDL: proatherosclerotic effects on endothelial cells and macrophages.
Journal of atherosclerosis and thrombosis, 2013 AIM Both oxidized LDL and carbamylated LDL are considered important for initiating atherosclerosis in patients with end-stage kidney disease through vascular endothelial cell dysfunction or injury.
E. Apostolov +6 more
semanticscholar +1 more source
Suppression of LDL Oxidation by Garlic [PDF]
The Journal of Nutrition, 2001 It has been known for several decades that hypercholesterolemia is a major risk factor for atherosclerosis and that lowering of cholesterol can significantly reduce risk for cardiovascular diseases. More recently, oxidation of LDL has been recognized as playing an important role in the initiation and progression of atherosclerosis.
openaire +2 more sources
Altered Susceptibility to in Vitro Oxidation of LDL in LDL Complexes and LDL Aggregates [PDF]
Annals of the New York Academy of Sciences, 1992 Low density lipoprotein (LDL) is known to form complexes with polysulfated compounds, like heparin, dextran sulfate (DS), and chondroitin sulfate. In particular, chondroitin 6-sulfate (C6S)-rich proteoglycans of the arterial intima can associate with LDL, resulting in accumulation of LDL in atherosclerotic lesions.
Marcela Hermann, Bernhard Gmeiner
openaire +5 more sources
Lipids, 2013 The antioxidant property of plasma high-density lipoprotein (HDL) is thought to be involved in potential anti-atherogenic effects but the exact mechanism is not known. We aimed to reveal the contribution of HDL on the elimination of lipid hydroperoxides (
Mari Kotosai +10 more
semanticscholar +1 more source
Oxidized LDL and the metabolic syndrome [PDF]
Future Lipidology, 2008 The metabolic syndrome is a common and complex disorder combining obesity, dyslipidemia, hypertension and insulin resistance. It is associated with a high cardiovascular risk that can only partially be explained by its components. There is evidence that low-grade inflammation and high oxidative stress add to this risk.
David R. Jacobs +2 more
openaire +3 more sources
Oxidatively Modified LDL Suppresses Lymphangiogenesis via CD36 Signaling
Antioxidants, 2021 Arterial accumulation of plasma-derived LDL and its subsequent oxidation contributes to atherosclerosis. Lymphatic vessel (LV)-mediated removal of arterial cholesterol has been shown to reduce atherosclerotic lesion formation.
Bhupesh Singla +4 more
doaj +1 more source
MCP-1 binds to oxidized LDL and is carried by lipoprotein(a) in human plasma
Journal of Lipid Research, 2013 Lipoprotein oxidation plays an important role in pathogenesis of atherosclerosis. Oxidized low density lipoprotein (OxLDL) induces profound inflammatory responses in vascular cells, such as production of monocyte chemoattractant protein-1 (MCP-1 ...
Philipp Wiesner +14 more
semanticscholar +1 more source
FEBS Open Bio, EarlyView.In human monocytic cells THP‐1, a limited uptake of native—not oxidized—LDL/VLDL induced expression of scavenger receptor A and cellular adhesion. Induction was inhibited by lysosomotropic (WR‐1065) and lipophilic (BHT) antioxidants and by siRNAs against ferritinophagy.
Martina Čierna +4 more
wiley +1 more source
Oxidized LDL Induces Alternative Macrophage Phenotype through Activation of CD36 and PAFR
Mediators of Inflammation, 2013 OxLDL is recognized by macrophage scavenger receptors, including CD36; we have recently found that Platelet-Activating Factor Receptor (PAFR) is also involved.
F. J. Rios +5 more
semanticscholar +1 more source