Results 111 to 120 of about 203,353 (285)

Targeting the PHB2–ACSL3 Lipid‐Remodeling Axis Overcomes Cisplatin Resistance by Restoring Ferroptosis in Gastric Cancer

Advanced Science, EarlyView.
ABSTRACT Platinum‐based chemotherapy resistance remains a major obstacle in gastric cancer (GC) treatment. Through integrated transcriptomic profiling of cisplatin‐resistant xenografts and pharmacogenomic interrogation of the NCI‐60 dataset, we identified Prohibitin‐2 (PHB2) as a previously unrecognized determinant of chemoresistance.
Liang Xu, Wanying Xiang, Xinyue Wang, Yue Pan, Jing Gao, Jiezhen Yang, Yufei Wang, Zhipu Zhu, Man Tong, Lei Jin, Yan Ye   +10 more
wiley   +1 more source

In Vivo Direct Reprogramming: Current Progress and Future Prospects from Mechanisms to Therapeutic Application

Advanced Science, EarlyView.
This review examines the potential of in vivo direct reprogramming in regenerative medicine for functional tissue restoration, highlighting the role of tissue‐resident cues in generating functionally mature reprogrammed cells from lineage‐related cells. It contains a discussion on mechanisms, reprogramming factors, delivery approaches, and applications
Rishabh Deo Singh, Mauro Calvoli, Kyeong Kyu Kim   +2 more
wiley   +1 more source

Biologically Active Oxidized Phospholipids [PDF]

Journal of Biological Chemistry, 1999
T M, McIntyre, G A, Zimmerman, S M, Prescott   +2 more
openaire   +2 more sources

Dual pKa Lipid Nanoparticles for Lung‐tropic mRNA Delivery and pH‐Programmed Endosomal Escape

Advanced Science, EarlyView.
Lipid nanoparticles’ bottleneck lies in low endosomal escape efficiency and liver‐dominant delivery after intravenous administration. To overcome these limitations, we present a stepwise pH‐programmed lipid nanoparticle system enabled by our newly synthesized ionizable lipid.
Seong Gi Lim, Minju Lee, Yiming Wang, Eunjin Choi, Ji Sun Park, Kyungmin Park, Hayoung Jeon, Donghyun Kim, Donghyun Lee, Yeeun Lee, Kee‐Pyo Kim, Eunha Kim, Heebeom Koo   +12 more
wiley   +1 more source

Structural Identification by Mass Spectrometry of Oxidized Phospholipids in Minimally Oxidized Low Density Lipoprotein That Induce Monocyte/Endothelial Interactions and Evidence for Their Presence in Vivo

, 1997
Entry of monocytes into the vessel wall is an important event in atherogenesis. Previous studies from our laboratory suggest that oxidized arachidonic acid-containing phospholipids present in mildly oxidized low density lipoproteins (MM-LDL) can activate
Navab, Mohamad, Wei Sha, Fogelman, Alan M, Sohvi Hörkkö, Palinski, Wulf, Berliner, Judith A, Watson, Andrew D, Robert G. Salomon, Alan M. Fogelman, Witztum, Joseph L, Norbert Leitinger, Mohamad Navab, Hörkkö, Sohvi, Joseph L. Witztum, Ganesamoorthy Subbanagounder, Andrew D. Watson, Faull, Kym F, Kym F. Faull, Dawn Schwenke, Judith A. Berliner, Sha, Wei, Schwenke, Dawn, Salomon, Robert G, Subbanagounder, Ganesamoorthy, Leitinger, Norbert, Wulf Palinski   +25 more
core   +1 more source

Oxidized phospholipids inhibit phagocytosis and impair outcome in gram-negative sepsis in vivo [PDF]

, 2007
Oxidized phospholipids that are generated during inflammation exert anti-inflammatory properties and prevent death during murine endotoxemia. Oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (OxPAPC) inhibits the interaction of LPS with
Knapp, Sylvia, Matt, Ulrich, Leitinger, Norbert, van der Poll, Tom, Sylvia Knapp, Ulrich Matt, Tom van der Poll, Norbert Leitinger   +7 more
core   +1 more source

Potential of Nanoparticle‐Based Phototherapies for Future Treatment of Uveal Melanoma

Advanced Science, EarlyView.
This review evaluates nanoparticle‐based phototherapies for uveal melanoma, highlighting emerging strategies to enhance tumor targeting, light delivery, and treatment precision. Preclinical data indicate improved efficacy and reduced toxicity, supporting their potential to enhance localized treatment and future translational advances. (Generated by the
Emilie Lambert, Christophe Nguyen, Sean Edward Dunn, Magali Gary‐Bobo, Jérôme Lacombe, Justin Moser, Frédéric Zenhausern, Jean‐Olivier Durand, Frédérique Cunin   +8 more
wiley   +1 more source

PhD

, 2008
dissertationAtherosclerosis leads to about 640,000 deaths every year in the United States and is the leading cause of death in this country. Activation of monocytes by oxidized low-density lipoprotein (LDL) is a critical step in atherosclerosis. Oxidized
Davies, Sean S.
core  

Specific Oxidized Phospholipids Inhibit Scavenger Receptor BI-mediated Selective Uptake of Cholesteryl Esters

, 2008
We have recently demonstrated that specific oxidized phospholipids (oxPCCD36) accumulate at sites of oxidative stress in vivo such as within atherosclerotic lesions, hyperlipidemic plasma, and plasma with low high-density lipoprotein levels.
Chen, Xi, Choi, Jaewoo, Xi Chen, Eugene A. Podrez, Ashraf, Mohammad Z., Podrez, Eugene A., Jaewoo Choi, Febbraio, Maria, Kar, Niladri S., Robert G. Salomon, Salomon, Robert G., Maria Febbraio, Mohammad Z. Ashraf, Niladri S. Kar   +13 more
core   +1 more source

ACSL4‐Dependent Lysosomal Lipid Peroxidation Links WTAP‐Mediated m6A Modification to Intervertebral Disc Degeneration

Advanced Science, EarlyView.
IL‐1β upregulates the protein level of WTAP, which promotes the m6A modification of ACSL4 mRNA in an IGF2BP2‐dependent manner, thereby enhancing its stability. The increased ACSL4 drives lipid peroxidation, leading to lysosomal membrane permeabilization (LMP) and impaired mitophagy, which collectively accelerate intervertebral disc degeneration (IVDD).
Shu Jia, Xu Gao, Laimin Zhu, Haixia Song, Jing Wu, Shang Chen, Sheng Gao, Lu Zhang, Chunyang Meng   +8 more
wiley   +1 more source