Results 21 to 30 of about 171,220 (334)

Group II truncated haemoglobin YjbI prevents reactive oxygen species-induced protein aggregation in Bacillus subtilis

eLife, 2022
Oxidative stress-mediated formation of protein hydroperoxides can induce irreversible fragmentation of the peptide backbone and accumulation of cross-linked protein aggregates, leading to cellular toxicity, dysfunction, and death.
Takeshi Imai, Ryuta Tobe, Koji Honda, Mai Tanaka, Jun Kawamoto, Hisaaki Mihara   +5 more
doaj   +1 more source

Characterization of theThreshold for NAD(P)H:quinone Oxidoreductase Activity in Intact Sulforaphane-treated Pulmonary Arterial Endothelial Cells [PDF]

, 2011
Treatment of bovine pulmonary arterial endothelial cells in culture with the phase II enzyme inducer sulforaphane (5 μM, 24 h; sulf-treated) increased cell-lysate NAD(P)H:quinone oxidoreductase (NQO1) activity by 5.7 ± 0.6 (mean ± SEM)-fold, but intact ...
Bongard, Robert D., Gastonguay, Adam J., Krenz, Gary S., Lindemer, Brian J., Merker, Marilyn P., Williams, Carol L.   +5 more
core   +2 more sources

Enzymatic Processes to Unlock the Lignin Value

Frontiers in Bioengineering and Biotechnology, 2018
Main hurdles of lignin valorization are its diverse chemical composition, recalcitrance, and poor solubility due to high-molecular weight and branched structure.
Veera Hämäläinen, Toni Grönroos, Anu Suonpää, Matti Wilhem Heikkilä, Bastiaan Romein, Petri Ihalainen, Sara Malandra, Klara R. Birikh   +7 more
doaj   +1 more source

Redox-controlled reorganization and flavin strain within the ribonucleotide reductase R2b–NrdI complex monitored by serial femtosecond crystallography

eLife, 2022
Redox reactions are central to biochemistry and are both controlled by and induce protein structural changes. Here, we describe structural rearrangements and crosstalk within the Bacillus cereus ribonucleotide reductase R2b–NrdI complex, a di-metal ...
Juliane John, Oskar Aurelius, Vivek Srinivas, Patricia Saura, In-Sik Kim, Asmit Bhowmick, Philipp S Simon, Medhanjali Dasgupta, Cindy Pham, Sheraz Gul, Kyle D Sutherlin, Pierre Aller, Agata Butryn, Allen M Orville, Mun Hon Cheah, Shigeki Owada, Kensuke Tono, Franklin D Fuller, Alexander Batyuk, Aaron S Brewster, Nicholas K Sauter, Vittal K Yachandra, Junko Yano, Ville RI Kaila, Jan Kern, Hugo Lebrette, Martin Högbom   +26 more
doaj   +1 more source

The Spermatophore in Glossina morsitans morsitans: Insights into Male Contributions to Reproduction. [PDF]

, 2016
Male Seminal Fluid Proteins (SFPs) transferred during copulation modulate female reproductive physiology and behavior, impacting sperm storage/use, ovulation, oviposition, and remating receptivity.
Abd-Alla, Adly MM, Aksoy, Emre, Aksoy, Serap, Attardo, Geoffrey M, Benoit, Joshua B, Malacrida, Anna R, Michalkova, Veronika, Scolari, Francesca, Takac, Peter   +8 more
core   +2 more sources

Inhibition of TXNRD or SOD1 overcomes NRF2-mediated resistance to β-lapachone [PDF]

, 2020
Alterations in the NRF2/KEAP1 pathway result in the constitutive activation of NRF2, leading to the aberrant induction of antioxidant and detoxification enzymes, including NQO1.
Boothman, David A., DeNicola, Gina M., Elkins, Cody M., Falzone, Aimee, Haura, Eric B., Prieto-Farigua, Nicolas, Torrente, Laura   +6 more
core   +1 more source

Structures and proton-pumping strategies of mitochondrial respiratory enzymes [PDF]

, 2001
Enzymes of the mitochondrial respiratory chain serve as proton pumps, using the energy made available from electron transfer reactions to transport protons across the inner mitochondrial membrane and create an electrochemical gradient used for the ...
Chan, Sunney I., Schultz, Brian E.
core   +1 more source

Identification of genes specifically required for the anaerobic metabolism of benzene in Geobacter metallireducens

Frontiers in Microbiology, 2014
Although the biochemical pathways for the anaerobic degradation of many of the hydrocarbon constituents in petroleum reservoirs have been elucidated, the mechanisms for anaerobic activation of benzene, a very stable molecule, are not known.
Tian eZhang, Tian eZhang, Pier-Luc eTremblay, Pier-Luc eTremblay, Akhilesh Kumar Chaurasia, Jessica A. Smith, Timothy S. Bain, Derek R. Lovley   +7 more
doaj   +1 more source

The Catalytic Cycle of the Antioxidant and Cancer-Associated Human NQO1 Enzyme: Hydride Transfer, Conformational Dynamics and Functional Cooperativity

Antioxidants, 2020
Human NQO1 [NAD(H):quinone oxidoreductase 1] is a multi-functional and stress-inducible dimeric protein involved in the antioxidant defense, the activation of cancer prodrugs and the stabilization of oncosuppressors.
Ernesto Anoz-Carbonell, David J. Timson, Angel L. Pey, Milagros Medina   +3 more
doaj   +1 more source

Deciphering the Role of Selenoprotein M

Antioxidants, 2023
Selenocysteine (Sec), the 21st amino acid, is structurally similar to cysteine but with a sulfur to selenium replacement. This single change retains many of the chemical properties of cysteine but often with enhanced catalytic and redox activity ...
Lance G. A. Nunes, Antavius Cain, Cody Comyns, Peter R. Hoffmann, Natalie Krahn   +4 more
doaj   +1 more source