Biotransformation of tobacco-derived Z-abienol into precursors of ambrox by newly identified Acinetobacter tjernbergiae LSC-2 [PDF]
Frontiers in MicrobiologyZ-abienol is a labdane diterpene present in tobacco leaves and is a key precursor for producing valuable aroma compounds such as ambrox. This study aimed to identify and characterize a bacterial strain that can efficiently degrade Z-abienol through ...
Gaolei Xi +10 more
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The Adaptation of MCF-7 Breast Cancer Spheroids to the Chemotherapeutic Doxorubicin: The Dynamic Role of Phase I Drug Metabolizing Enzymes [PDF]
MetabolitesBackground/Objectives: Drug resistance (DR) is a major challenge in cancer therapy, contributing to approximately 90% of cancer-related deaths. While alterations in drug metabolism are known to be key drivers of DR, their role—particularly in the early ...
Daniel Crispim +3 more
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Targeting of the intracellular redox balance by metal complexes towards anticancer therapy
Frontiers in Chemistry, 2022 The development of cancers is often linked to the alteration of essential redox processes, and therefore, oxidoreductases involved in such mechanisms can be considered as attractive molecular targets for the development of new therapeutic strategies.
María Isabel Murillo +2 more
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Inspired by Nature—Functional Analogues of Molybdenum and Tungsten-Dependent Oxidoreductases
Molecules, 2022 Throughout the previous ten years many scientists took inspiration from natural molybdenum and tungsten-dependent oxidoreductases to build functional active site analogues.
Sebastian Pätsch +4 more
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Enzymatic Bioprospecting of Fungi Isolated from a Tropical Rainforest in Mexico
Journal of Fungi, 2021 The humid tropical environment provides an ideal place for developing a high diversity of plants; this is why it is an interesting site for the enzymatic bioprospecting of fungi that are responsible for the recycling of organic matter in an efficient and
Karla Peraza-Jiménez +4 more
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Laccases: Versatile Biocatalysts for the Synthesis of Heterocyclic Cores
Molecules, 2021 Laccases are multicopper oxidases that have shown a great potential in various biotechnological and green chemistry processes mainly due to their high relative non-specific oxidation of phenols, arylamines and some inorganic metals, and their high redox ...
Ana Catarina Sousa +2 more
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mBio, 2021 The nicotinamide cofactor specificity of enzymes plays a key role in regulating metabolic processes and attaining cellular homeostasis. Multiple studies have used enzyme engineering tools or a directed evolution approach to switch the cofactor preference
Madeleine Bouzon +12 more
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Biomolecules, 2022 The worldwide access to pharmaceuticals and their continuous release into the environment have raised a serious global concern. Pharmaceuticals remain active even at low concentrations, therefore their occurrence in waterbodies may lead to successive ...
Helena Sá +3 more
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Clinical evaluation of oxidative stress in patients with diabetes mellitus type II: Impact of acute exercise [PDF]
Vojnosanitetski Pregled, 2009 Background/Aim. Exercise is a well recognized model of oxidative stress and, also, an important tool in diabetes management. The aim of our study was to evaluate oxidative stress in patients with diabetes mellitus type 2 and to determine influence of ...
Kostić Nada +6 more
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Fungal Treatment for the Valorization of Technical Soda Lignin
Journal of Fungi, 2021 Technical lignins produced as a by-product in biorefinery processes represent a potential source of renewable carbon. In consideration of the possibilities of the industrial transformation of this substrate into various valuable bio-based molecules, the ...
Mariane Daou +12 more
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