Results 1 to 10 of about 43,837 (307)
Frontiers in Microbiology, 2018 Oxidoreductases are ubiquitous enzymes that catalyze an extensive range of chemical reactions with great specificity, efficiency, and selectivity. Most oxidoreductases are nicotinamide cofactor-dependent enzymes with a strong preference for NADP or NAD ...
Andrea M Chánique
exaly +3 more sources
Biotransformation of tobacco-derived Z-abienol into precursors of ambrox by newly identified Acinetobacter tjernbergiae LSC-2 [PDF]
Frontiers in MicrobiologyZ-abienol is a labdane diterpene present in tobacco leaves and is a key precursor for producing valuable aroma compounds such as ambrox. This study aimed to identify and characterize a bacterial strain that can efficiently degrade Z-abienol through ...
Gaolei Xi +10 more
doaj +2 more sources
The Adaptation of MCF-7 Breast Cancer Spheroids to the Chemotherapeutic Doxorubicin: The Dynamic Role of Phase I Drug Metabolizing Enzymes [PDF]
MetabolitesBackground/Objectives: Drug resistance (DR) is a major challenge in cancer therapy, contributing to approximately 90% of cancer-related deaths. While alterations in drug metabolism are known to be key drivers of DR, their role—particularly in the early ...
Daniel Crispim +3 more
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A Structure-Based Approach for Detection of Thiol Oxidoreductases and Their Catalytic Redox-Active Cysteine Residues [PDF]
PLoS Computational Biology, 2009 Cysteine (Cys) residues often play critical roles in proteins, for example, in the formation of structural disulfide bonds, metal binding, targeting proteins to the membranes, and various catalytic functions.
Stefano M Marino, Vadim N Gladyshev
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The Role of Oxidoreductases in Determining the Function of the Neisserial Lipid A Phosphoethanolamine Transferase Required for Resistance to Polymyxin [PDF]
PLoS ONE, 2014 The decoration of the lipid A headgroups of the lipooligosaccharide (LOS) by the LOS phosphoethanolamine (PEA) transferase (LptA) in Neisseria spp. is central for resistance to polymyxin.
Jhuma Ganguly +2 more
exaly +2 more sources
mBio, 2021 The nicotinamide cofactor specificity of enzymes plays a key role in regulating metabolic processes and attaining cellular homeostasis. Multiple studies have used enzyme engineering tools or a directed evolution approach to switch the cofactor preference
Madeleine Bouzon +12 more
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Fungal Treatment for the Valorization of Technical Soda Lignin
Journal of Fungi, 2021 Technical lignins produced as a by-product in biorefinery processes represent a potential source of renewable carbon. In consideration of the possibilities of the industrial transformation of this substrate into various valuable bio-based molecules, the ...
Mariane Daou +12 more
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Laccases: Versatile Biocatalysts for the Synthesis of Heterocyclic Cores
Molecules, 2021 Laccases are multicopper oxidases that have shown a great potential in various biotechnological and green chemistry processes mainly due to their high relative non-specific oxidation of phenols, arylamines and some inorganic metals, and their high redox ...
Ana Catarina Sousa +2 more
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Biomolecules, 2022 The worldwide access to pharmaceuticals and their continuous release into the environment have raised a serious global concern. Pharmaceuticals remain active even at low concentrations, therefore their occurrence in waterbodies may lead to successive ...
Helena Sá +3 more
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Journal of Fungi, 2021 A dye-decolorizing peroxidase (DyP) from Irpex lacteus was cloned and heterologously expressed as inclusion bodies in Escherichia coli. The protein was purified in one chromatographic step after its in vitro activation.
Laura Isabel de Eugenio +6 more
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