Results 91 to 100 of about 91,003 (373)

Crystal structures of archaeal 2-oxoacid:ferredoxin oxidoreductases from Sulfolobus tokodaii

Scientific Reports, 2016
As the first three-dimensional structure of the two-subunit type 2-oxoacid:ferredoxin oxidoreductases (OFOR) from archaea, we solved the crystal structures of STK_23000/STK_22980 (StOFOR1) and STK_24350/STK_24330 (StOFOR2) from Sulfolobus tokodaii.
Zhen Yan, A. Maruyama, T. Arakawa, S. Fushinobu, T. Wakagi   +4 more
semanticscholar   +1 more source

Dithiolopyrrolone Natural Products : Isolation, Synthesis and Biosynthesis [PDF]

, 2013
Peer reviewedPublisher ...
Deng, Hai, Huang, Sheng, Qin, Zhiwei, Yu, Yi   +3 more
core   +2 more sources

Onion‐Mitochondria Inhibit Lipopolysaccharide‐Induced Acute Lung Injury by Shaping Lung Macrophage Mitochondrial Function

Advanced Science, EarlyView.
Proposed model of orally administered onion mitochondria (O‐Mit) uptake by lung macrophages and fuse with macrophage mitochondria (M‐Mit). This fusion reprograms the metabolism of dysfunctional M‐Mit in lipopolysaccharide‐induced murine acute lung injury by modulating dynamin‐related protein 1 (DRP1) phosphorylation and cardiolipin peroxidation ...
Qingbo Xu, Yun Teng, Yinan Huang, Jingyao Mu, Lucy Teng, Hongjia Qian, Qiming Huang, Minmin Liu, Yi Zou, Lifeng Zhang, Michael L Merchant, Xiang Zhang, Jun Yan, Huang‐Ge Zhang   +13 more
wiley   +1 more source

Serological Diagnosis of Liver Metastasis in Patients with Breast Cancer

Cancer Biology & Medicine, 2012
Objective: To diagnose and explore the serological diagnostic factors for liver metastasis in patients with breast cancer before symptoms occur. Methods: A total of 430 female in-patients with breast cancer of stages 0 to IIIC who came to Tianjin Medical
Rui Cao, Li-ping Wang
doaj   +3 more sources

The oxygen-independent metabolism of cyclic monoterpenes in Castellaniella defragrans 65Phen [PDF]

, 2014
BACKGROUND: The facultatively anaerobic betaproteobacterium Castellaniella defragrans 65Phen utilizes acyclic, monocyclic and bicyclic monoterpenes as sole carbon source under oxic as well as anoxic conditions.
Becher, D., Disch, E., Harder, J., Huettel, B., Markert, S., Petasch, J., Reinhardt, R., Schweder, T.   +7 more
core   +2 more sources

Genetic and Functional Evidence Links Germline Biallelic Inactivating Variants in WWOX to Histological Mixed‐Type Thyroid Cancer

Advanced Science, EarlyView.
The role of germline WWOX loss‐of‐function variants in oncogenesis has remained poorly characterized. This study provides the first comprehensive genetic and functional evidence that such variants promote tumorigenesis through the disruption of multiple tumor‐suppressive mechanisms.
Xiaopeng Zhang, Jian Qi, Jialiang Wang, Zhipeng Wang, Yongguang Wang, Zongtao Hu, Ao Xu, Bo Hong, Hongzhi Wang   +8 more
wiley   +1 more source

Survey of Human Oxidoreductases and Cytochrome P450 Enzymes Involved in the Metabolism of Xenobiotic and Natural Chemicals

Chemical Research in Toxicology, 2014
Analyzing the literature resources used in our previous reports, we calculated the fractions of the oxidoreductase enzymes FMO (microsomal flavin-containing monooxygenase), AKR (aldo-keto reductase), MAO (monoamine oxidase), and cytochrome P450 ...
Slobodan Petar Rendic, F. Guengerich
semanticscholar   +1 more source

Photoprotective role of NADPH:protochlorophyllide oxidoreductase A [PDF]

Proceedings of the National Academy of Sciences, 2008
A homology model of NADPH:protochlorophyllide (Pchlide) oxidoreductase A (POR; E.C. 1.3.33.1) of barley is developed and verified by site-directed mutagenesis. PORA is considered a globular protein consisting of nine α-helices and seven β-strands.
Frank, Buhr, Majida, El Bakkouri, Oscar, Valdez, Stephan, Pollmann, Nikolai, Lebedev, Steffen, Reinbothe, Christiane, Reinbothe   +6 more
openaire   +2 more sources

Targeting the hypoxic fraction of tumours using hypoxia activated prodrugs [PDF]

, 2016
The presence of a microenvironment within most tumours containing regions of low oxygen tension or hypoxia has profound biological and therapeutic implications.
A Foehrenbacher, A Foehrenbacher, A Jain, AA Gluck, AG Heijden van der, AI Minchinton, AJ Lin, AL Harris, AM Intlekofer, AM Lim, AV Patterson, AV Patterson, BA Teicher, C Cazares-Korner, C Karnthaler-Benbakka, C Yoon, CJ Koch, CP Guise, CP Guise, CP Guise, CP Guise, CR Nishida, CT Lee, D Moradi Manesh, D Rischin, D Rischin, E Viry, EA Oostveen, EM Hammond, F Meng, F Meng, F Perche, FW Hunter, FW Hunter, GA Choudry, GJ Weiss, GJ Weiss, GK Abou-Alfa, HL McLeod, HR Hendriks, IB Barsoum, IM Pires, J Benito, J Hu, J Treat, J Ye, JA Plumb, JD Sun, JH Schellens, JK Saggar, JK Saggar, JM Brown, JW Wojtkowiak, JX Duan, K Balamurugan, K Hendricksen, K Hendricksen, KE Lindquist, KJ Williams, KN Ganjoo, KO Hicks, KP Papadopoulos, KR Luoto, L Marcu, L Ming, LH Gray, LH Patterson, LH Patterson, LJ Peters, LY Dirix, M Ahmadi, M Hockel, M Konopleva, M Mehibel, M O’Rourke, MB Jameson, ME Trinkaus, MJ Borad, MJ McKeage, MJ McKeage, MR Abbattista, MR Albertella, N Pavlidis, N Robertson, O Tredan, O Tredan, OP Friery, P Kucharzewska, P Vaupel, P Workman, PA DiSilvestro, PC Mack, PJ Houghton, Q Chang, QT Le, QT Le, R Grepin, R Puri, R Zhu, RA Cairns, RC Sun, RD Traver, RF Anderson, RG Gieling, Rischin D, Hicks RJ, Fisher R, Binns D, Corry J, Porceddu S, Peters LJ, Trans-Tasman Radiation Oncology Group S, RM Phillips, RM Phillips, Roger M. Phillips, S Portwood, SG Peeters, SK Chitneni, SM Raleigh, SP Chawla, SR McKeown, SS Shinde, SV Karakashev, TA Connors, TG Graeber, V Liapis, VA Miller, WA Denny, Williamson SK, Crowley JJ, Lara PN, Jr., McCoy J, Lau DH, Tucker RW, Mills GM, Gandara DR, Southwest Oncology Group Trial S, WM Oldham, WP Steward, WR Wilson, Y Gu, Y Gu   +126 more
core   +1 more source

Mitochondrial CISD1 Modulates Microglial Metabolic Reprogramming to Drive Stress Susceptibility in Mice

Advanced Science, EarlyView.
CDGSH iron sulfur domain 1 (CISD1) mitigates oxidative stress by promoting NADH oxidation and Coenzyme Q (CoQ) reduction. Under chronic stress, elevated CISD1 expression in microglia enhances NAD⁺ production, thereby increasing GAPDH activity and glycolytic flux, while reducing ATP synthesis by inhibiting proton transfer from mitochondrial complexes I ...
Wanting Dong, Duo Liu, Songsen Fu, Jiaming Zhang, Xi Chen, Songqiang Huang   +5 more
wiley   +1 more source