Results 91 to 100 of about 43,837 (307)

Establishment of a humanized SCA2 mouse model carrying a CAA disruption preventing CAG repeat expansion in pathogenic genes

Animal Models and Experimental Medicine, EarlyView.
In this study, we established a mouse model in which CAG repeats do not undergo microsatellite instability (MSI) across generations. A humanized ATXN2 cDNA with four CAA interruptions within 73 CAG expansions was inserted into the Rosa26 locus of C57BL/6J mice. At the same time, a 23 CAG control mouse model was also generated.
Yao Zhang, Yufei Li, Lin Zhang, Zhaoqing Li, Keqin Lin, Kai Huang, Zhaoqing Yang, Shaohui Ma, Hao Sun, Xiaochao Zhang   +9 more
wiley   +1 more source

Transformation of Steroids by Cell-free Preparations of Penicillium lilacinum NRRL 895. V. Properties of 20-Oxopregnane Side Chain Cleavage and 20(alpha+beta)-Oxidoreductase Activities. [PDF]

, 1974
Kjell Carlström, Gunnel Sievers, Jacques Simonet, Jostein Krane, A. Taticchi, Bengt Mannervik   +5 more
openalex   +1 more source

Engineered C–N Lyases for Stereoselective Synthesis of Tertiary Amines

Angewandte Chemie International Edition, EarlyView.
EDDS lyase was subjected to iterative cycles of site‐saturation mutagenesis and screened for increased activity for the addition of 2‐((methylamino)methyl)aniline to fumarate. The final mutant, EDDS lyase CEA, accepts various N‐methyl‐1‐phenylmethanamines derivatives, yielding N,N‐disubstituted L‐aspartic acids, as well as several ortho‐substituted ...
Laura Bothof, Xiaofang Gong, Marrit E. Onclin, Peter Fodran, Gerrit J. Poelarends   +4 more
wiley   +1 more source

Enzymatic Diagnostics of Soil Health of the European Part of Russia with Lead Contamination

Soil Systems
Lead (Pb) is one of the most common environmental pollutants. Lead has an acute toxic effect on soil biotas and the enzymatic system of soils. The objective of this study is to carry out enzymatic diagnostics of soil health in the European part of Russia
Tatiana Minnikova, Sergey Kolesnikov, Anna Kuzina, Dmitry Trufanov, Ekaterina Khrapay, Anatoly Trushkov   +5 more
doaj   +1 more source

Emergence of Staphylococcus aureus Resistance to Antimicrobial Peptides Nisin, NZ2114 and Bacitracin Involves Multiple Phenotypic Changes

Animal Research and One Health, EarlyView.
The AMP‐induced mutant Staphylococcus aureus strain nzR showed increased resistance, five gene mutations, and decreased surface anion levels. AMPs affect the NDH‐2 protein encoded by ndh gene inhibiting the growth of S. aureus. The deletion of the ndh gene promotes the development of AMPs resistance.
Lingyu Xiao, Xingyuan Ma, Ping Tian, Lianbin Li, Zafir Muhammad, Xiaokun Wang, Xuemei Xue, Jinhe Xiao, Liangjun Zheng, F. A. El‐Gohary, Xin Zhao, Junning Pu, Huping Xue   +12 more
wiley   +1 more source

Revitalization of Soil Contaminated by Petroleum Products Using Materials That Improve the Physicochemical and Biochemical Properties of the Soil

Molecules
One of the key challenges in environmental protection is the reclamation of soils degraded by organic pollutants. Effective revitalization of such soils can contribute to improving the climate and the quality of feed and food, mainly by eliminating ...
Jadwiga Wyszkowska, Agata Borowik, Magdalena Zaborowska, Jan Kucharski   +3 more
doaj   +1 more source

The stereospecificity of nicotinamide–adenine dinucleotide-dependent oxidoreductases from plants [PDF]

, 1972
D. D. Davies, Ana Teixeira, P. Kenworthy
openalex   +1 more source

Fabrication of Polypyrrole–Polystyrene Sulfonate by Amperometric Biosensor‐Based Electropolymerization for Cholesterol Determination in Serum

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Since cholesterol triggers many diseases, many methods have been developed for its determination. In this study, an alternative system for cholesterol determination was developed by preparing amperometric biosensors. In the development of the biosensor, Pt/polypyrrole–polystyrene sulfonate film was prepared by electropolymerization of ...
Alaa Anwer Ali Dada, Ertan Yildirim, Sinan Mithat Muhammed, Servet Çete   +3 more
wiley   +1 more source

The intracellular localization of glycollate oxidoreductase in Euglena gracilis [PDF]

, 1971
Janet M. Lord, M. J. Merrett
openalex   +1 more source

Sustainable biofuel production from fish processing waste: lipase‐catalyzed hydroesterification of tilapia residual oil

Biofuels, Bioproducts and Biorefining, EarlyView.
Abstract Fishing waste and byproducts, whether naturally occurring or from industrial processing, are important sources of high‐value compounds. Fertilizers, biomaterials, cosmetics, biolubricants, and biodiesel are some of the substances that can be obtained from these residues. The objective of this study was to conduct a theoretical and experimental
Patrick da Silva Sousa, Francisco Simão Neto, Paulo Gonçalves de Sousa Junior, Marcos Carlos de Mattos, Maria Alexsandra de Sousa Rios, Aluísio Marques da Fonseca, Diego Lomonaco, José C. S. dos Santos   +7 more
wiley   +1 more source