Results 121 to 130 of about 91,003 (373)
Integrative Omics Defines Metabolic Biomarkers and Genetic Regulatory Mechanisms of Mortality Risk
Advanced Science, EarlyView.Understanding mortality mechanisms remains a fundamental challenge. Through multi‐omics analysis of a three‐generation chicken model, are identified 45,585 mQTLs and establish a 16‐metabolite predictor of mortality. An inflammation‐growth trade‐off and evolutionarily conserved pathways involving butyrate–microbiota interactions and L‐cysteine's dual ...
Peihao Liu +10 more
wiley +1 more source
The Problem of Mycotoxins and Approaches to Its Solution
Вестник войск РХБ защитыMycotoxins are characterized by wide structural diversity and variety of origins.Various physical and chemical methods are tried for neutralization of mycotoxins.Enzymatic treatment looks like nature-like and efficient method of detoxification ...
E. N. Efremenko, I. V. Lyagin
doaj +1 more source
In Vivo Effects of Methionine Sulfoxide Reductase Deficiency in Drosophila melanogaster
Antioxidants, 2018 The deleterious alteration of protein structure and function due to the oxidation of methionine residues has been studied extensively in age-associated neurodegenerative disorders such as Alzheimer’s and Parkinson’s Disease.
Lindsay Bruce +7 more
doaj +1 more source
RNAi Regulator C3PO Promotes Arbovirus Infection in Insect Vectors
Advanced Science, EarlyView.RNA interference (RNAi) is vital for eukaryotes to defend against virus infection. The C3PO complex takes part in RNAi but its role in regulating viral infection remains unclear. This work finds that insect C3PO facilitates arbovirus replication by degrading precursors of miRNAs, especially miR‐971‐3p.
Yan Xiao +7 more
wiley +1 more source
Some Like It Hot –Structural Changes in Extremophile Rubredoxin at 120 °C
Angewandte Chemie, EarlyView.We reveal the high temperature crystal structure of a hyperthermophilic (Pyrococcus furiosus) rubredoxin at 393 K (120 °C), together with multiple complementary structures down to 100 K. The results are compared with molecular dynamics calculations. Significant changes in H‐bonding are observed.
Tzanko Doukov +4 more
wiley +2 more sources
EVALUATING THE EFFECTIVENESS OF CURETTAGE OF PERIODONTAL POCKETS ON CYTOENZIMOCHEMICAL INDICATORS
Кубанский научный медицинский вестник, 2017 The results of the study cytoenzimechemical biologically research of neutrophilic granulocytes For an assessment of efficiency of medical manipulations after curettage of periodontal pockets Average degree weight of inflammatory process.
M. S. GANDZHA +2 more
doaj +1 more source
Advanced Science, EarlyView.A luciferase is used as biosensor for aldehydes, produced enzymatically from different monomeric building blocks of plastics like polyurethanes (PUs). The screening platform is used to monitor esterase, amidase, and urethanase activity and to guide the selection of enzyme variants with improved hydrolytic activities toward difficult to hydrolyze ...
Ina Somvilla +12 more
wiley +1 more source
Inactivation of the Burkholderia Toxin Malleicyprol by Enzymatic Cyclopropanol Ring Opening
Angewandte Chemie, EarlyView.Burkholderia pseudomallei and Burkholderia mallei are dangerous pathogens that cause severe diseases with high mortality rates. Their virulence relies in part on malleicyprols, potent toxins containing a highly reactive cyclopropanol group. In this study, we identify BurK, a heme‐dependent oxidoreductase that neutralizes malleicyprols by enzymatically ...
Jonas Fiedler +4 more
wiley +2 more sources
Oxidoreductase activity is necessary for N-glycosylation of cysteine-proximal acceptor sites in glycoproteins [PDF]
, 2014 Н. А. Черепанова +2 more
openalex +1 more source
Sulphur(lone pair)…π interactions with FAD in flavoenzymes [PDF]
, 2018 The interactions of π-systems with lone-pairs of electrons are known and have been described in biological systems, involving lone-pairs derived from metals, metalloids, sulphur, oxygen and nitrogen.
Caracelli, Ignez +4 more
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