Results 181 to 190 of about 91,003 (373)

Global Stress Responses Identify the Functionally Divergent Regulators Required for Candida auris Commensalism and Pathogenicity

Exploration, EarlyView.
Candida auris is an emerging multidrug‐resistant fungal pathogen that poses a serious global health threat. In our study, we comprehensively delineate both the pan‐genomic and transcriptomic features of C. auris. Intriguingly, our findings reveal an unexpected alkaline pH‐dependent regulation required for C. auris virulence and commensalism mediated by
Chaoyue Xu, Wanxing Xu, Yushun Yuan, Xiaoqing Chen, Ouyang Mo, Zhe Yin, Xinhua Huang, Yuanyuan Wang, Lingfei Hu, Wenwen Xue, Yun Zou, Luyao Zhang, Kunlin Li, Yueru Tian, Jihong Liu, Sichu Xiong, Lei Wu, Yanmei Dong, Guangsheng Chen, Yuping Zhang, Zili Zhou, Ming Guan, Xiaotian Huang, Zhiyi He, Lin Zhong, Lingbing Zeng, Pei Hao, Xiaoqi Zheng, Changbin Chen, Ning‐Ning Liu, Dongsheng Zhou   +30 more
wiley   +1 more source

Phloretin Suppresses Preadipocyte Differentiation by Targeting PPARγ/Transferrin to Activate Ferroptosis Signaling Pathway

Food Frontiers, EarlyView.
Phloretin alleviates HFD‐induced obesity and suppresses adipogenesis by activating the ferroptosis pathway, potentially via targeting PPARγ and transferrin. ABSTRACT Phloretin, a plant‐derived dihydrochalcone bioactive compound, potentially modulates preadipocyte differentiation, although this remains controversial and requires further clarification ...
Jie Li, Qihui Zhu, Yang Li, Haiyu Zhao, Yi Bi, Chuanying Pan, Min Wang, Lin Han, Xianyong Lan   +8 more
wiley   +1 more source

Pituitary 5 alpha-dihydroprogesterone 3 alpha-hydroxysteroid oxidoreductases. Subcellular location and properties of NADH- and NADPH-linked activities.

, 1980
James E. Krause, Harry J. Karavolas
openalex   +1 more source

Action Spectra of Chlorophyll a Biosynthesis in Cyanobacteria: Dark-Operative Protochlorophyllide Oxidoreductase-Deficient Mutants [PDF]

, 2009
Yang Gao, Wei Xiong, Ming J. He, Li Tang, Jin Xiang, Qing Wu   +5 more
openalex   +1 more source

Identification of Cathepsin H and Metabolic Traits as Potential Biomarkers for Lung Cancer by Mendelian Randomization and Single‐Cell Transcriptomics

Advanced Genetics, EarlyView.
This study explores the link between CTSH and lung cancer, covering global trends in lung cancer and hyperglycemia, MR analysis of CTSH and 233 metabolic traits, and scRNA analysis, along with multi‐level validation of CTSH expression in LUAD. These findings offer valuable insights into lung cancer biology and provide new perspectives for biomarker ...
Chenghu Song, Weici Liu, Zhao He, Jiwei Liu, Ruixin Wang, Lei Wu, Yize Wang, Mingfeng Zheng, Dong Tian, Wenjun Mao   +9 more
wiley   +1 more source

Catalog of 434 single-nucleotide polymorphisms (SNPs) in genes of the alcohol dehydrogenase, glutathione S-transferase, and nicotinamide adenine dinucleotide, reduced (NADH) ubiquinone oxidoreductase families [PDF]

, 2001
Aritoshi Iida, S. Saito, Akihiro Sekine, Takuya Kitamoto, Tetsuhisa Kitamura, C. Mishima, Satoshi Osawa, Kazuhiro Kondo, S. Harigae, Yusuke Nakamura   +9 more
openalex   +1 more source

Oxidoreductases on their way to industrial biotransformations.

Biotechnology Advances, 2017
Angel T. Martı́nez, F. J. Ruiz-Dueñas, S. Camarero, A. Serrano, Dolores Linde, H. Lund, J. Vind, Morten Tovborg, Owik M. Herold-Majumdar, M. Hofrichter, Christiane Liers, R. Ullrich, K. Scheibner, G. Sannia, Alessandra Piscitelli, C. Pezzella, M. Sener, Sibel Kilic, W. V. van Berkel, V. Guallar, M. Lucas, R. Zuhse, R. Ludwig, F. Hollmann, Elena Fernández-Fueyo, E. Record, C. Faulds, M. Tortajada, I. Winckelmann, J. Rasmussen, M. Gelo-Pujic, A. Gutiérrez, J. D. del Río, J. Rencoret, M. Alcalde   +34 more
semanticscholar   +1 more source

Functional Screening of NDUFAF6 Variants in Knockout Cells and Complementary Computational Analysis

Journal of Clinical Laboratory Analysis, EarlyView.
We established an ATP‐based functional screening system in NDUFAF6 knockout cells to evaluate the pathogenicity of gene variants associated with mitochondrial dysfunction. Our results highlight the limitations of in silico predictions and underscore the necessity of experimental validation for accurate variant interpretation.
Feng Jiang, Ayumu Sugiura, Yoshihito Kishita, Kohta Nakamura, Xinju Qi, Yuxin Liu, Kei Murayama, Yasushi Okazaki   +7 more
wiley   +1 more source

Cytochrome b-deficient mutants of the ubiquinol-cytochrome c oxidoreductase in Saccharomyces cerevisiae. Consequence for the functional and structural characteristics of the complex

, 1993
Danielle Lemesle-Meunier, Paule Brivet‐Chevillotte, J.-P. di Rago, Piotr P. Słonimski, Christophe Bruel, Thierry Tron, Nicole Forget   +6 more
openalex   +1 more source

Effects of catechins, resveratrol, silymarin components and some of their conjugates on xanthine oxidase‐catalyzed xanthine and 6‐mercaptopurine oxidation

Journal of the Science of Food and Agriculture, Volume 105, Issue 5, Page 2765-2776, 30 March 2025.
Abstract BACKGROUND Over the past two decades, the global incidence of gout has markedly increased, affecting people worldwide. Considering the side effects of xanthine oxidase (XO) inhibitor drugs (e.g. allopurinol and febuxostat) used in the treatment of hyperuricemia and gout, the potential application of phytochemicals has been widely studied.
Tímea Bencsik, Orsolya Balázs, Róbert G Vida, Balázs Z Zsidó, Csaba Hetényi, Kateřina Valentová, Miklós Poór   +6 more
wiley   +1 more source