Results 181 to 190 of about 44,293 (292)

Superoxide Activates Ferroptosis via the Haber‐Weiss Reaction and Enhances Age‐Related Macular Degeneration

open access: yesAging Cell, EarlyView.
Superoxide activates ferroptosis through the Haber‐Weiss reaction and contributes to the development of age‐related macular degeneration. MnSOD‐depleted RPE cells are susceptible to blue light‐induced ferroptosis. MnSOD deficiency promotes Hsp70‐driven ubiquitin‐mediated degradation of GPX4.
Ying Huang   +10 more
wiley   +1 more source

Molecular and cellular mechanisms underlying gyrate atrophy: Why is the retina primarily affected?

open access: yesActa Ophthalmologica, EarlyView.
Abstract Gyrate atrophy of the choroid and retina (GACR; OMIM #258870) is a rare early‐onset autosomal recessive disorder, caused by bi‐allelic pathogenic variants in the gene coding for ornithine aminotransferase (OAT) resulting in hyperornithinaemia.
Mark J. N. Buijs   +12 more
wiley   +1 more source

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