Results 241 to 250 of about 41,420 (299)

Deciphering enzymatic potential in metagenomic reads through DNA language models. [PDF]

Nucleic Acids Res
Prabakaran R, Bromberg Y.
europepmc   +1 more source

Steroidogenic compensation and lipid deficiency with enhanced NAD+ salvage in small‐for‐gestational‐age placenta

The FEBS Journal, EarlyView.
Fetal growth restriction is associated with placental metabolic adaptations. In small‐for‐gestational‐age placenta (SGA), cholesterol receptors and steroidogenic enzymes are upregulated, enhancing steroidogenesis. NAD salvage pathway is also increased to support NADP+/NADPH requirements.
Serena Xodo, Lorenza Driul, Vanessa Tolotto, Eros Di Giorgio, Luigi E. Xodo   +4 more
wiley   +1 more source

Comparative fecal microbiome analysis of the endangered Volcano rabbit (Romerolagus diazi) reveals a microbial core in contrasting habitats of Central Mexico. [PDF]

PLoS One
Montes-Carreto LM, Arellano-Hernández HD, Guerrero JA, Martinez-Romero E.   +3 more
europepmc   +1 more source

Tyrosine residues at the substrate binding site in human NQO1 homodimer: Protein conformational dynamics and optimization of substrate binding geometry

The FEBS Journal, EarlyView.
Human NAD(P)H:quinone oxidoreductase 1 is a homodimeric flavoenzyme crucial for redox metabolism and linked to significant health issues. Point mutations at Tyr126 and Tyr128 demonstrate their essential roles in optimizing substrate binding geometry for catalysis, as well as in half‐site reactivity and conformational dynamics during the enzyme's ...
Maribel Rivero, Juan Luis Pacheco‐Garcia, Pavla Vankova, Dmitry Loginov, Isabel Quereda‐Moraleda, Jose Manuel Martin‐Garcia, Petr Man, Angel Luis Pey, Milagros Medina   +8 more
wiley   +1 more source

Interpretable convolutional neural networks for sequence-based classification and discovery of plastic-degrading enzymes. [PDF]

Appl Environ Microbiol
Lee W-H, Dumontet L, Jung K, Lee H, Thapa G, Oh T-J, Kang M.   +6 more
europepmc   +1 more source

Arsenite methyltransferase 3 is required for mitochondrial function and hepatic lipid metabolism

The FEBS Journal, EarlyView.
AS3MT is a protein that helps the body process arsenic, a naturally occurring toxin found in water and soil. We discovered it also helps cells make and use energy properly. Without AS3MT, cells' mitochondria do not work well, leading to fatty liver and reduced activity. Increasing AS3MT in liver cells restores energy and protects against arsenic damage,
Patrice Delaney, James Griffin, Nouf Khan, Balnur Ibrash, Matthew J. O'Connor, Tomas Venit, Elizabeth Mayela Ambrosio, Spiros A. Pergantis, Elke Ober, Piergiorgio Percipalle, Kirsten C. Sadler   +10 more
wiley   +1 more source

Antioxidant protein signatures in honey: botanical influence and proteomic variability. [PDF]

Food Chem X
Čeksterytė V, Kaupinis A, Gvazdauskė G, Navakauskienė R, Jaškūnė K.   +4 more
europepmc   +1 more source

Molecular dynamics simulations and fluorescence spectroscopy suggest reduced tryptophan‐to‐heme energy transfer facilitates lignin degradation in ClassII peroxidases

The FEBS Journal, EarlyView.
In lignin peroxidase and versatile peroxidase, low FRET from buried Trp to heme promotes long‐range electron transfer (LRET) from substrate to heme. This efficient electron flow is facilitated by reduced FRET competition. This mechanism likely evolved to enable the effective degradation of bulky, high‐redox‐potential lignin that cannot reach the enzyme'
Yi Ren, Dale Ang, Haluk Ertan, Anne Poljak, Janice R. Aldrich‐Wright, Wallace J. Bridge, Khawar Sohail Siddiqui   +6 more
wiley   +1 more source

Characterising the gut microbiomes of two baleen whales with different feeding and migratory strategies. [PDF]

Anim Microbiome
Parikh A, O'Rorke R, Carroll EL, Vermeulen E, Harcourt R, Constantine R, Plön S, Rayment WJ, Chariton A.   +8 more
europepmc   +1 more source