Results 101 to 110 of about 47,898 (257)

Stereoselective Synthesis of Glycomimetic Amines From Biomass‐Derived Cyrene

European Journal of Organic Chemistry, EarlyView.
2,3,4‐Trideoxy‐2‐mannosamines, including the unsubstituted one, are accessible as the only endo diastereoisomers by reductive amination of the green solvent Cyrene, derived from pyrolysis of cellulose containing waste biomass. The products are useful chiral synthetic intermediate to nitrogenated glycomimetics.
Debora Pratesi, Marta Rigacci, Francesca Cardona, Camilla Matassini, Andrea Goti   +4 more
wiley   +1 more source

Modulating IDO1 and TDO Inhibition Through Structural Modification of Diaryl Hydroxylamines. [PDF]

ChemMedChem
Diaryl hydroxylamines have emerged as promising scaffolds for targeting the tryptophan‐catabolizing enzymes indoleamine 2,3‐dioxygenase 1 (IDO1) and tryptophan 2,3‐dioxygenase (TDO), key drivers of tumor immune escape. Building on the reported dual IDO1/TDO inhibitory activity of O‐((3,5‐difluorophenyl)(phenyl)methyl)hydroxylamine, a series of diaryl ...
Foscolos AS, Pappas A, Petroulias CN, Kapella A, Prifti GM, Zoidis G, Papadopoulos M, Mpakali A, Chiotellis A.   +8 more
europepmc   +2 more sources

Extending the semi-empirical PM6 method for carbon oxyacid pKa prediction to sulfonic acids: Application towards congener-specific estimates for the environmentally and toxicologically relevant C1 through C8 perfluoroalkyl derivatives [PDF]

, 2009
A positive bias in the semi-empirical PM6 method for estimating pKa values of sulfonic acids was corrected by a correlation developed between non-adjusted PM6 pKa values and the corresponding experimentally obtained/estimated acidity constants for a ...
Kaya Forest, Ken J. Friesen, Sierra Rayne   +2 more
core   +1 more source

Dynamic Kinetic Resolution of Axially Chiral Heterobiaryl N‐Oxides via Peptide‐Catalyzed Aldol Reaction

European Journal of Organic Chemistry, EarlyView.
Resin‐supported tripeptide achieved the dynamic kinetic resolution in the catalytic aldol reaction of formylated heterobiaryl N‐oxides with high efficiency and enantioselectivity. The system features a broad substrate scope and a recyclable catalyst.
Jiaqi Tian, Isao Yoshikawa, Akihiro Sakama, Kazuaki Kudo   +3 more
wiley   +1 more source

Combination of Hydrogen and Halogen Bonds in the Crystal Structures of 5-Halogeno-1H-isatin-3-oximes: Involvement of the Oxime Functionality in Halogen Bonding

Molecules
Various functional groups have been considered as acceptors for halogen bonds, but the oxime functionality has received very little attention in this context.
Eric Meier, Wilhelm Seichter, Monika Mazik   +2 more
doaj   +1 more source

Crystal structure of (1Z,2E)-cinnamaldehyde oxime

Acta Crystallographica Section E: Crystallographic Communications, 2015
The title compound, C9H9NO, crystallized with two independent molecules (A and B) in the asymmetric unit. The conformation of the two molecules differs slightly with the phenyl ring in molecule A, forming a dihedral angle of 15.38 (12)° with the oxime ...
Bernhard Bugenhagen, Nuha Al Soom, Yosef Al Jasem, Thies Thiemann   +3 more
doaj   +1 more source

Synthetic strategies for 5- and 6-membered ring azaheterocycles facilitated by iminyl radicals [PDF]

, 2016
The author thanks EaStCHEM for financial support.The totality of chemical space is so immense that only a small fraction can ever be explored. Computational searching has indicated that bioactivity is associated with a comparatively small number of ring ...
Walton, John Christopher
core   +2 more sources

Mechanical stability in flexible perovskite solar cells: Interface engineering and device design

FlexMat, EarlyView.
Statistics of the improvement methods for f‐PSCs. Abstract Flexible perovskite solar cells (f‐PSCs) demonstrate significant potential for application in next‐generation wearable electronic devices and photovoltaic building integration due to their high power conversion efficiency and excellent power‐to‐weight ratio. However, the inherent brittleness of
Hong‐Yi Hou, Xin‐Yi Zeng, Jian‐Xin Tang, Yan‐Qing Li   +3 more
wiley   +1 more source

Silver and platinum-catalysed addition of O–H and N–H bonds to allenes [PDF]

, 2014
Transition-metal catalysed nucleophile addition to allenes is a very powerful tool for the synthesis of functionalised molecules containing heteroatoms, heterocycles in the intramolecular version, or allyl derivatives in the intermolecular version.
Munoz-Herranz, Maria
core   +1 more source

Aliphatic Poly(Carbonate)s with Acid Responsive Release Mechanisms for Micellar Anti‐Tumor Drug Delivery

Macromolecular Rapid Communications, EarlyView.
Micellar systems based on biodegradable aliphatic polycarbonates and acid‐responsive triggers enhance drug solubility, stability, and tumor‐selective release. This review covers micelles with acid‐cleavable drug linkages and those that disassemble via acid‐sensitive functionalities.
Adrian V. Hauck, Lutz Nuhn
wiley   +1 more source