Results 111 to 120 of about 30,052 (257)
Small‐Molecule Kinase Inhibitors Modulating Circadian Rhythms
Medicinal Research Reviews, EarlyView.ABSTRACT The circadian clock mechanism generates 24‐h rhythms crucial for regulating various physiological processes, and its dysregulation has been implicated in numerous diseases. In cells, the circadian clock operates through a transcriptional‐translational feedback loop, where phosphorylation plays a pivotal role in maintaining accurate circadian ...
Irene Castellino +3 more
wiley +1 more source
Veterinary Medicine and ScienceObjective This study aimed to characterize the pharmacokinetic profiles of milbemycin oxime in Pekingese dogs following a single oral (PO) and intravenous (IV) dose. Six clinically healthy Pekingese dogs, with an average body weight (BW) of 4.75 kg, were
Ze‐En Li +7 more
doaj +1 more source
Original scientific paper A regioselective alkylation at the C-6 hydroxyl group of
, 2004 : Erythromycin A contains five hydroxyl groups. The regioselective alkylation at the C-6 hydroxyl group was achieved to an extent of more than 97 % when a 9-O-substituted erythromycin A-9-oxime was employed as the ...
Erythromycin A-oxime Derivatives
core
Oxime-Urethane-Based Self-Healing Polyurethane for Achieving Complex Structures via 3D Printing
3D printing has emerged as a highly accurate, highly customizable, and low-cost fabrication method to realize structures with designed geometry. However, the integral printing of complex structures, such as suspended structures, still poses significant ...
Jiyang Zuo (18239139) +6 more
core +1 more source
Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine
Medicinal Research Reviews, EarlyView.ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli +5 more
wiley +1 more source
Small, EarlyView.This study presents a robust strategy for 3D printing conductive, mechanically resilient MXene–CNF composite structures using a single‐step freeze‐induced crosslinking method. The printed architectures remain stable in both wet and dry states, exhibit high electrical conductivity and mechanical strength, and demonstrate practical application in fully ...
Nuzhet Inci Kilic +5 more
wiley +1 more source
Organophosphate Poisoning: Review of Prognosis and Management
Advanced Biomedical ResearchThe high annual mortality rate of organophosphorus (OP) poisoning indicates that the treatment is mostly ineffective in this regard. It has been suggested to add calcium channel blocking (CCB) drugs or magnesium sulfate (MgSO4) to normal care to decrease
Shafeajafar Zoofaghari +2 more
doaj +1 more source
Polarity‐engineered Sn‐Ti cluster photoresists for sub‐10‐nm high‐resolution lithography
Smart Molecules, EarlyView.Enhancing the polarity of clusters can optimize their patterning performance; inspired by this strategy, we designed polarity‐enhanced Sn‐Ti oxo clusters via ligand engineering. The optimal TS‐3 with exposure‐induced polarity switch achieves 8 nm patterning in lithography and achieves simultaneous improvement in resolution and patterning performance ...
Daohan Wang +10 more
wiley +1 more source
The Constitution of Fluorescein Oxime and the Hydroquinonephthalein Oximes. [PDF]
Acta Chemica Scandinavica, 1966 Henning Lund +7 more
openaire +1 more source
, 2016 Imine-based reactions are useful for a wide range of bioconjugation applications. Although aniline is known to catalyze the oxime ligation reaction under physiological conditions, it suffers from slow reaction kinetics, specifically when a ketone is ...
Mohammad Rashidian (1360473) +5 more
core +1 more source