Results 61 to 70 of about 47,946 (259)

Synthesis, Biological Evaluation, and Docking Studies of Novel Bisquaternary Aldoxime Reactivators on Acetylcholinesterase and Butyrylcholinesterase Inhibited by Paraoxon

Molecules, 2018
Nerve agents and oxon forms of organophosphorus pesticides act as strong irreversible inhibitors of two cholinesterases in the human body: acetylcholinesterase (AChE; EC 3.1.1.7) and butyrylcholinesterase (BChE; EC 3.1.1.8), and are therefore highly ...
Kamil Kuca, Daniel Jun, Lucie Junova, Kamil Musilek, Martina Hrabinova, Jorge Alberto Valle da Silva, Teodorico Castro Ramalho, Marian Valko, Qinghua Wu, Eugenie Nepovimova, Tanos Celmar Costa França   +10 more
doaj   +1 more source

Nap1L4a Cooperates with Scl/Klf1 to Recruit H2A.Z in Mediating Interactions Among Cis‐Regulatory Elements and Transcription Required for Primitive Erythropoiesis in Zebrafish

Advanced Science, EarlyView.
Nap1l4a is required in erythropoiesis and hypoxia responses via physical interaction with Klf1 and Scl to recruit the histone variant H2A.Z. This facilitates its associated cis‐regulatory element (CRE) remodeling and the consequent chromatin assembly, and activates the transcription of erythroid lineage‐specific genes.
JiaHao Shi, FuMing Lai, Zheng Shen, XiaoYan Zhang, HanFei Wang, WenYe Liu, YunLong Wang, KuanYu Li, GuoLiang Li, YaPing Fang, Jing‐Xia Liu   +10 more
wiley   +1 more source

4-Ethoxyimino-N′-methoxypyrrolidin-1-ium-3-carboximidamidium dichloride

Acta Crystallographica Section E, 2009
The title compound, C8H18N4O22+·2Cl−, contains two oxime groups. The methyl oxime group has a Z configuration, and the ethyl oxime group is disordered, with both Z and E configurations in occupancies of 0.840 (8) and 0.160 ...
doaj   +1 more source

Orthogonal, metal-free surface modification by strain-promoted azide–alkyne and nitrile oxide–alkene/alkyne cycloadditions [PDF]

, 2012
In this article we present a fast and efficient methodology for biochemical surface patterning under extremely mild conditions. Micropatterned azide/benzaldoxime-surfaces were prepared by microcontact printing of a heterobifunctional cyclooctyne oxime ...
Arlinghaus, Heinrich F, Burley, Glenn A, Ravoo, Bart Jan, Rinnen, Stefan, Schulz, Christian, Singh, Ishwar, Wendeln, Christian   +6 more
core   +1 more source

Stimuli‐Responsive Supramolecular Biomaterials for Cancer Theranostics

Advanced Science, EarlyView.
The ultimate goal of cancer theranostics is to get imaging agents and therapeutic cargo to tumor sites when and where they are required. “Smart” systems should be developed. This review discusses the characteristics of physiological stimuli, types and action modes of external stimuli, construction approaches and working principles, as well as ...
Wenting Hu, Binglin Ye, Guocan Yu, Feihe Huang, Zhengwei Mao   +4 more
wiley   +1 more source

Discrete and Polymeric, Mono- and Dinuclear Silver Complexes of a Macrocyclic Tetraoxime Ligand with AgI–AgI Interactions

Sensors, 2013
Macrocyclic compounds that can bind cationic species efficiently and selectively with their cyclic cavities have great potential as excellent chemosensors for metal ions.
Mitsuhiko Shionoya, Mihoko Yamada, Jun-ichiro Tanihira, Shohei Tashiro   +3 more
doaj   +1 more source

SiO2@FeSO4 nano composite: A recoverable nano-catalyst for eco-friendly synthesis oximes of carbonyl compounds [PDF]

Nanochemistry Research, 2016
Various aldoximes and ketoximes synthesis of corresponding aldehydes and ketones in the presence of SiO2@FeSO4 nano composite as recoverable nano catalyst and NH2OH·HCl.
Mostafa Karimkoshteh, Marziyeh Bagheri, Behzad Zeynizadeha   +2 more
doaj   +1 more source

Expanding the Repertoire of Natural Product-Inspired Ring Pairs for Molecular Recognition of DNA [PDF]

, 2011
A furan amino acid, inspired by the recently discovered proximicin natural products, was incorporated into the scaffold of a DNA-binding hairpin polyamide.
Arcamone F., Belitsky J. M., Best T. P., Boger D. L., Bremer R. E., Chenoweth D. M., Daniel A. Gubler, Dervan P. B., Dervan P. B., Doss R. M., Edelson B. S., Fiedler H. P., Jevgenij A. Raskatov, Jordan L. Meier, Katy A. Muzikar, Kopka M. L., Marques M. A., Matsuda H., Mrksich M., Muzikar K. A., Nickols N. G., Nickols N. G., Olenyuk B. Z., Pelton J. G., Peter B. Dervan, Pilch D. S., Renneberg D., Schneider K., Stover J. S., Wade W. S., White S., Wolter F. E., Woods C. R.   +32 more
core   +3 more sources

A Reactive Antagonist Strategy: Cysteine‐Directed Covalent Molecular Glue in Plant Hormone Receptor Regulation

Advanced Science, EarlyView.
The plant hormone jasmonate is perceived by COI1‐JAZ co‐receptors comprising a single F‐box protein COI1 and multiple JAZ repressors with overlapping functions, complicating genetic analysis. We present a reactive antagonist (RA) strategy that selectively promotes COI1 binding to a cysteine‐engineered JAZ variant while blocking wild‐type JAZs, enabling
Minoru Ueda, Kotaro Matsumoto, Takao Nomura, Yousuke Takaoka, Taichi Okumura, Wataru Kozaki, Hikaru Hoshikawa, Yuho Nishizato, Andrea Chini, Roberto Solano, Katsumi Maenaka   +10 more
wiley   +1 more source

Catechol Derivative‐Based Bioadhesives: Molecular Design for Precision Medical Adhesion

Advanced Science, EarlyView.
This study utilizes tree‐inspired side‐chain engineering to graft five catechol derivatives onto PVA, systematically revealing how side‐chain length and substituents regulate adhesion and cohesion properties. Among them, the PVA‐CA patch demonstrates superior tissue adhesion, biocompatibility, and promotes regeneration, establishing a programmable ...
Xueyu Wang, Zixin Yang, Shan Wang, Weiwei Tan, Zhirui He, Qinyu Duan, Huanan Wang, Tao Chen, Shanshan Hu   +8 more
wiley   +1 more source