Results 41 to 50 of about 46,055 (292)

Selamectin is the avermectin with the best potential for Buruli ulcer treatment [PDF]

, 2015
A comprehensive analysis was done to evaluate the potential use of anti-parasitic macrocyclic lactones (including avermectins and milbemycins) for Buruli ulcer (BU) therapy.
Gerd Pluschke, Scherr, Nicole, Thompson, Charles J., Charles J Thompson, Nicole Scherr, Ramón-García, Santiago, Santiago Ramón-García, Pluschke, Gerd, Thompson CJ, Pluschke G, Pluschke Gerd, Ramón-García Santiago, Ramón-García S, Scherr Nicole, Thompson Charles J., Scherr N   +15 more
core   +2 more sources

Amidoximes and Oximes: Synthesis, Structure, and Their Key Role as NO Donors

Molecules, 2019
Nitric oxide (NO) is naturally synthesized in the human body and presents many beneficial biological effects; in particular on the cardiovascular system.
Tanya Sahyoun, Axelle Arrault, Raphaël Schneider   +2 more
doaj   +1 more source

Efficacy Assessment of an Uncharged Reactivator of NOP-Inhibited Acetylcholinesterase Based on Tetrahydroacridine Pyridine-Aldoxime Hybrid in Mouse Compared to Pralidoxime

Biomolecules, 2020
(1) Background: Human exposure to organophosphorus compounds employed as pesticides or as chemical warfare agents induces deleterious effects due to cholinesterase inhibition. One therapeutic approach is the reactivation of inhibited acetylcholinesterase
André-Guilhem Calas, Anne-Sophie Hanak, Nina Jaffré, Aurélie Nervo, José Dias, Catherine Rousseau, Charlotte Courageux, Xavier Brazzolotto, Pascal Villa, Adeline Obrecht, Jean-François Goossens, Christophe Landry, Johan Hachani, Fabien Gosselet, Marie-Pierre Dehouck, Jagadeesh Yerri, Maria Kliachyna, Rachid Baati, Florian Nachon   +18 more
doaj   +1 more source

Site‐Specific Protein Bioconjugation Through Cellular Incorporation of Noncanonical Amino Acids

Angewandte Chemie, EarlyView.
Genetic code expansion (GCE) enables site‐specific installation of noncanonical amino acids containing bioorthogonal conjugation handles, allowing precise, homogeneous protein modification. This review examines the principles of orthogonal translation, surveys the chemistries available for chemoselective labeling, and highlights emerging multi‐site ...
Rahul Sarkar, Manas Joshi, Abhishek Chatterjee   +2 more
wiley   +2 more sources

Advancements in catalytic hydrogenation of nitrocyclohexane to cyclohexanone oxime

Green Energy & Environment
Cyclohexanone oxime serves as a crucial intermediate in the synthesis of caprolactam, which is an essential precursor for manufacturing nylon fibers, high-performance engineering plastics, and specialized plastic films.
Jinzhi Lu, Tongxin Song, Weiping Ding, Yan Zhu   +3 more
doaj   +1 more source

Oxime-Based Carbonates as Useful Reagents for Both N-Protection and Peptide Coupling

Molecules, 2012
We have demonstrated that oxime-based mixed carbonates are very effective reagents for both N-protection and peptide coupling.
Yahya El-Sayed Jad, Sherine N. Khattab, Ayman El-Faham, Fernando Albericio   +3 more
doaj   +1 more source

Breakthrough Design of Highly Potent Antivirals Against Wild‐Type HIV‐1 and Lenacapavir‐Resistant M66I Variant

Angewandte Chemie, EarlyView.
Lenacapavir, the first‐in‐class drug targeting HIV‐1 capsid, is a breakthrough drug in HIV‐1 treatment and prophylaxis. However, a single M66I mutation confers complete viral resistance to lenacapavir. We report herein the design and synthesis of innovative R2 analogs demonstrating low nM potency against HIV‐1 M66I and excellent pharmacokinetics in ...
Nicolas Jamey, D. M. Nirosh Udayanga, Huanchun Zhang, Roshan Katekar, Wei Xie, Shreya M. Ravichandran, Xinyong Cai, Zachary C. Lorson, William M. McFadden, Won Hee Ryu, Jiashu Xie, Karen A. Kirby, Stefan G. Sarafianos, Zhengqiang Wang   +13 more
wiley   +2 more sources

Crystal Structure and Hydrogen Bonding Study of (10E)-2,2-Dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione 10-Oxime Derived From a-Lapachone

Molecules, 2011
The compound (10E)-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione-10-oxime (1) was synthesized from a-lapachone and hydroxylamine chloride in alkaline medium. Single-crystals suitable for X-ray diffraction measurements were grown from an ethanol
Lorenzo C. Visentin, Ari M. da Silva, Aurelio B. B. Ferreira, Marcelo H. Herbst, Andrea R. da Silva   +4 more
doaj   +1 more source

An efficient method for selective oxidation of (oxime)Pt(II) to (oxime)Pt(IV) species using N,N-dichlorotosylamide

, 2020
The oxidation of (oxime)PtII species using the electrophilic chlorine-based oxidant N,N-dichlorotosylamide (4-CH3C6H4SO2NCl2) was studied. The reactions of trans-[PtCl2(oxime)2] (where oxime = acetoxime, cyclopentanone oxime, or acetaldoxime) with this ...
Bulatov, Evgeny, Afanasenko, Anastasiia M., Chulkova, Tatiana G., Haukka, Matti, Dolgushin, Fedor M.   +4 more
core   +1 more source

Biodegradable Conductors for Implantable and Wearable Transient Bioelectronics

Advanced Functional Materials, EarlyView.
Biodegradable conductors are essential building blocks for transient bioelectronics, enabling temporary sensing, stimulation, and energy transfer while eliminating the need for device retrieval. This review summarizes biodegradable metals, conducting polymers, ionic conductors, and conductive composites, highlighting degradation mechanisms, material ...
Yicheng Zhu, Yijun Liu, Naoji Matsuhisa
wiley   +1 more source