Results 41 to 50 of about 47,898 (257)

Advancements in catalytic hydrogenation of nitrocyclohexane to cyclohexanone oxime

Green Energy & Environment
Cyclohexanone oxime serves as a crucial intermediate in the synthesis of caprolactam, which is an essential precursor for manufacturing nylon fibers, high-performance engineering plastics, and specialized plastic films.
Jinzhi Lu, Tongxin Song, Weiping Ding, Yan Zhu   +3 more
doaj   +1 more source

Novel Group of AChE Reactivators—Synthesis, In Vitro Reactivation and Molecular Docking Study

Molecules, 2018
The acetylcholinesterase (AChE) reactivators (e.g., obidoxime, asoxime) became an essential part of organophosphorus (OP) poisoning treatment, together with atropine and diazepam.
David Malinak, Eugenie Nepovimova, Daniel Jun, Kamil Musilek, Kamil Kuca   +4 more
doaj   +1 more source

Oximes: Novel Therapeutics with Anticancer and Anti-Inflammatory Potential

Biomolecules, 2021
Oximes have been studied for decades because of their significant roles as acetylcholinesterase reactivators. Over the last twenty years, a large number of oximes have been reported with useful pharmaceutical properties, including compounds with ...
Igor A. Schepetkin, Mark B. Plotnikov, Andrei I. Khlebnikov, Tatiana M. Plotnikova, Mark T. Quinn   +4 more
doaj   +1 more source

Amidoximes and Oximes: Synthesis, Structure, and Their Key Role as NO Donors

Molecules, 2019
Nitric oxide (NO) is naturally synthesized in the human body and presents many beneficial biological effects; in particular on the cardiovascular system.
Tanya Sahyoun, Axelle Arrault, Raphaël Schneider   +2 more
doaj   +1 more source

Efficacy Assessment of an Uncharged Reactivator of NOP-Inhibited Acetylcholinesterase Based on Tetrahydroacridine Pyridine-Aldoxime Hybrid in Mouse Compared to Pralidoxime

Biomolecules, 2020
(1) Background: Human exposure to organophosphorus compounds employed as pesticides or as chemical warfare agents induces deleterious effects due to cholinesterase inhibition. One therapeutic approach is the reactivation of inhibited acetylcholinesterase
André-Guilhem Calas, Anne-Sophie Hanak, Nina Jaffré, Aurélie Nervo, José Dias, Catherine Rousseau, Charlotte Courageux, Xavier Brazzolotto, Pascal Villa, Adeline Obrecht, Jean-François Goossens, Christophe Landry, Johan Hachani, Fabien Gosselet, Marie-Pierre Dehouck, Jagadeesh Yerri, Maria Kliachyna, Rachid Baati, Florian Nachon   +18 more
doaj   +1 more source

Salicylaldehyde hydrazones: buttressing of outer sphere hydrogen-bonding and copper-extraction properties [PDF]

, 2017
Salicylaldehyde hydrazones are weaker copper extractants than their oxime derivatives, which are used in hydrometallurgical processes to recover ~20 % of the world’s copper.
Bauer, Heiko, Forgan, Ross S., Lin, Tai, Parsons, Simon, Roach, Benjamin D., Rogers, David M., Tasker, Peter A., White, Fraser J.   +7 more
core   +1 more source

Convergent Valorization via Scalable C═N Bond Electrosynthesis Through Metal‐Dopant Interfacial Engineering in a Flow Electrolyzer

Angewandte Chemie, EarlyView.
This study establishes an innovative approach to synthesize organonitrogens featuring C═N bonds efficiently using non‐precious metal‐doped MoS2 in a flow electrolyzer. Fe dopant significantly enhances Faradaic efficiency and yield rate, achieving over 81% and 2630 mmol h−1 g−1 for formaldoxime production. This platform upcycles pollutants into valuable
Ruijie Yi, Jiu Chen, Xiaoyong Mo, Tian Zeng, Jingtao Zhou, Fulai Liu, Shu‐Chih Haw, Yong Chen, Ruosong Li, Edmund C. M. Tse   +9 more
wiley   +2 more sources

Oxime-Based Carbonates as Useful Reagents for Both N-Protection and Peptide Coupling

Molecules, 2012
We have demonstrated that oxime-based mixed carbonates are very effective reagents for both N-protection and peptide coupling.
Yahya El-Sayed Jad, Sherine N. Khattab, Ayman El-Faham, Fernando Albericio   +3 more
doaj   +1 more source

In vivo imaging of pyrrole-imidazole polyamides with positron emission tomography [PDF]

, 2008
The biodistribution profiles in mice of two pyrrole-imidazole polyamides were determined by PET. Pyrrole-imidazole polyamides are a class of small molecules that can be programmed to bind a broad repertoire of DNA sequences, disrupt transcription factor ...
Bergstr  m, Burns, Chou, D. A. Harki, D. B. Stout, Dervan, Dervan, Dudouet, Edelson, Gross, Harapanhalli, Hsu, K  hnast, Lee, Lendvai, M. E. Phelps, N. Satyamurthy, P. B. Dervan, Phelps, Phelps, Poethko, Puckett, Roivainen, Schottelius, Tavitian, Toyokuni, Trauger   +26 more
core   +3 more sources

Catechol Derivative‐Based Bioadhesives: Molecular Design for Precision Medical Adhesion

Advanced Science, EarlyView.
This study utilizes tree‐inspired side‐chain engineering to graft five catechol derivatives onto PVA, systematically revealing how side‐chain length and substituents regulate adhesion and cohesion properties. Among them, the PVA‐CA patch demonstrates superior tissue adhesion, biocompatibility, and promotes regeneration, establishing a programmable ...
Xueyu Wang, Zixin Yang, Shan Wang, Weiwei Tan, Zhirui He, Qinyu Duan, Huanan Wang, Tao Chen, Shanshan Hu   +8 more
wiley   +1 more source