Results 21 to 30 of about 30,052 (257)

Functionalised oximes : emergent precursors for carbon-, nitrogen- and oxygen-centred radicals [PDF]

, 2016
The author thanks EaStCHEM for financial support.Oxime derivatives are easily made, are non-hazardous and have long shelf lives. They contain weak N–O bonds that undergo homolytic scission, on appropriate thermal or photochemical stimulus, to initially ...
John C. Walton, Walton, John Christopher, John Walton   +2 more
core   +1 more source

Pyridinium-2-carbaldoximes with quinolinium carboxamide moiety are simultaneous reactivators of acetylcholinesterase and butyrylcholinesterase inhibited by nerve agent surrogates

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
The pyridinium-2-carbaldoximes with quinolinium carboxamide moiety were designed and synthesised as cholinesterase reactivators. The prepared compounds showed intermediate-to-high inhibition of both cholinesterases when compared to standard oximes. Their
Hyun Myung Lee, Rudolf Andrys, Jakub Jonczyk, Kyuneun Kim, Avinash G. Vishakantegowda, David Malinak, Adam Skarka, Monika Schmidt, Michaela Vaskova, Kamil Latka, Marek Bajda, Young-Sik Jung, Barbara Malawska, Kamil Musilek   +13 more
doaj   +1 more source

Novel Tryptanthrin Derivatives with Selectivity as c–Jun N–Terminal Kinase (JNK) 3 Inhibitors

Molecules, 2023
The c-Jun N-terminal kinase (JNK) family includes three proteins (JNK1-3) that regulate many physiological processes, including cell proliferation and differentiation, cell survival, and inflammation.
Igor A. Schepetkin, Oleksander S. Karpenko, Anastasia R. Kovrizhina, Liliya N. Kirpotina, Andrei I. Khlebnikov, Stepan I. Chekal, Alevtyna V. Radudik, Maryna O. Shybinska, Mark T. Quinn   +8 more
doaj   +1 more source

Sustainable Electrosynthesis of Cyclohexanone Oxime through Nitrate Reduction on a Zn-Cu Alloy Catalyst [PDF]

, 2023
Cyclohexanone oxime is an important precursor for Nylon-6 and is typically synthesized via the nucleophilic addition-elimination of hydroxylamine with cyclohexanone. Current technologies for hydroxylamine production are, however, not environment-friendly
Tengfei, Li, Shaktiswaran, Udayasurian, Hayley, Andrews, Anna, Ciotti, Jonathan, Sharp, Max, García-Melchor   +5 more
core   +2 more sources

Abnormal KCC2 expression and function in a mouse model of epilepsy and tuberous sclerosis complex. [PDF]

Epilepsia
Abstract Objective Drug‐resistant epilepsy is a common, severe manifestation of the genetic disorder tuberous sclerosis complex (TSC). Although significant mechanistic and therapeutic advances have been made in TSC, treatments for seizures remain largely ineffective.
Guo D, Han L, Rensing NR, Jansen LA, Wong M.   +4 more
europepmc   +2 more sources

Enantioselective Synthesis of Cyclic Nitrones and Oxime Ethers by Chemoselective Allylic Alkylation of Oximes [PDF]

, 2020
The enantio- and chemoselective iridium-catalyzed N- and O-allylation of oximes is described for the first time. Kinetic resolution in an intramolecular setting provides access to cyclic nitrones, oxime ethers and enantioenriched aliphatic allylic ...
Tobias, Sandmeier, Erick, Carreira
core   +1 more source

The Evaluation of the Reactivating and Neuroprotective Efficacy of Two Newly Prepared Bispyridinium Oximes (K305, K307) in Tabun-Poisoned Rats—A Comparison with Trimedoxime and the Oxime K203

Molecules, 2017
The ability of two newly developed oximes (K305, K307) to protect tabun-poisoned rats from tabun-induced inhibition of brain acetylcholinesterase, acute neurotoxic signs and symptoms and brain damage was compared with that of the oxime K203 and ...
Jiri Kassa, Jan Misik, Jana Hatlapatkova, Jana Zdarova Karasova, Vendula Sepsova, Filip Caisberger, Jaroslav Pejchal   +6 more
doaj   +1 more source

Nanoparticulate transport of oximes over an in vitro blood-brain barrier model [PDF]

, 2010
Background: Due to the use of organophosphates (OP) as pesticides and the availability of OP-type nerve agents, an effective medical treatment for OP poisonings is still a challenging problem.
Tikva Vogel, Kreuter, Jörg (Prof. Dr.), Sascha Wien, Zensi, Anja, Kufleitner, Jürgen, Jörg Kreuter, Wien, Sascha, Jürgen Kufleitner, Bungert, Judith, Wagner, Sylvia, Judith Bungert, Dadparvar, Miriam, Vogel, Tikva, Anja Zensi, Sylvia Wagner, Worek, Franz, Miriam Dadparvar, Hagen von Briesen, Briesen, Hagen von, Franz Worek   +19 more
core   +2 more sources

Photochemical e-z isomerisation and cyclisation in an arylidenecycloakanone oxime ether system [PDF]

, 1994
The synthesis and photochemistry of a number of arylidenecycloalkanone oxime ethers has been investigated . Irradiation of E,E- 2-benzylidenecyclopentanone oxime O-allyl ether results in rapid E-Z isomérisation around the carbon-nitrogen double bond ...
Austin, Mark
core   +2 more sources

Triplet Energy Transfer Strategy for Visible Light Activation of Bio-Based Oxime Esters in Photopolymerization and 3D Printing. [PDF]

Small
Bio‐based oxime esters are converted into efficient metal‐free photoinitiators for 405 nm LEDs and sunlight by Dexter‑type triplet energy transfer from ITX, enabling fast and deep visible light curing, high‐resolution 3D printing and improved cytocompatibility.
Yang K, Dietlin C, Ohl C, Manivel M, Morlet-Savary F, Schmitt M, Audran G, Joly JP, Zhang J, Xiao P, Lalevée J.   +10 more
europepmc   +2 more sources