Results 31 to 40 of about 46,055 (292)

Pyridinium-2-carbaldoximes with quinolinium carboxamide moiety are simultaneous reactivators of acetylcholinesterase and butyrylcholinesterase inhibited by nerve agent surrogates

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
The pyridinium-2-carbaldoximes with quinolinium carboxamide moiety were designed and synthesised as cholinesterase reactivators. The prepared compounds showed intermediate-to-high inhibition of both cholinesterases when compared to standard oximes. Their
Hyun Myung Lee, Rudolf Andrys, Jakub Jonczyk, Kyuneun Kim, Avinash G. Vishakantegowda, David Malinak, Adam Skarka, Monika Schmidt, Michaela Vaskova, Kamil Latka, Marek Bajda, Young-Sik Jung, Barbara Malawska, Kamil Musilek   +13 more
doaj   +1 more source

Novel Tryptanthrin Derivatives with Selectivity as c–Jun N–Terminal Kinase (JNK) 3 Inhibitors

Molecules, 2023
The c-Jun N-terminal kinase (JNK) family includes three proteins (JNK1-3) that regulate many physiological processes, including cell proliferation and differentiation, cell survival, and inflammation.
Igor A. Schepetkin, Oleksander S. Karpenko, Anastasia R. Kovrizhina, Liliya N. Kirpotina, Andrei I. Khlebnikov, Stepan I. Chekal, Alevtyna V. Radudik, Maryna O. Shybinska, Mark T. Quinn   +8 more
doaj   +1 more source

Functionalised oximes : emergent precursors for carbon-, nitrogen- and oxygen-centred radicals [PDF]

, 2016
The author thanks EaStCHEM for financial support.Oxime derivatives are easily made, are non-hazardous and have long shelf lives. They contain weak N–O bonds that undergo homolytic scission, on appropriate thermal or photochemical stimulus, to initially ...
John C. Walton, Walton, John Christopher, John Walton, Walton, John Christopher; id_orcid   +3 more
core   +1 more source

The Evaluation of the Reactivating and Neuroprotective Efficacy of Two Newly Prepared Bispyridinium Oximes (K305, K307) in Tabun-Poisoned Rats—A Comparison with Trimedoxime and the Oxime K203

Molecules, 2017
The ability of two newly developed oximes (K305, K307) to protect tabun-poisoned rats from tabun-induced inhibition of brain acetylcholinesterase, acute neurotoxic signs and symptoms and brain damage was compared with that of the oxime K203 and ...
Jiri Kassa, Jan Misik, Jana Hatlapatkova, Jana Zdarova Karasova, Vendula Sepsova, Filip Caisberger, Jaroslav Pejchal   +6 more
doaj   +1 more source

Cytotoxic and genotoxic effects of oxime β-lapachone in human cancer cells: selectivity toward NCI-H460 and insights from molecular docking [PDF]

Hum Cell
Maria Francilene Souza Silva, Lara Polyana Silva Ramos, Fátima de Cassia Evangelista de Oliveira, Bruno Marques Soares, Daniel Pascoalino Pinheiro, Igor Frederico da Silveira Ramos, Rayran Walter Ramos de Sousa, Victória Laysna dos Anjos Santos, Arlan de Assis Gonsalves, Paulo Michel Pinheiro Ferreira, Heurison de Sousa e Silva, Cleônia Roberta Melo Araújo, Pessoa Cr, Márcia dos Santos Rizzo, Marcília Pinheiro da Costa   +14 more
openalex   +2 more sources

Photochemical e-z isomerisation and cyclisation in an arylidenecycloakanone oxime ether system [PDF]

, 1994
The synthesis and photochemistry of a number of arylidenecycloalkanone oxime ethers has been investigated . Irradiation of E,E- 2-benzylidenecyclopentanone oxime O-allyl ether results in rapid E-Z isomérisation around the carbon-nitrogen double bond ...
Austin, Mark
core   +2 more sources

The Separation of Cobalt by Solvent Extraction Using Oxime-Amine Mixture System

Journal of MMIJ, 2017
Extraction behavior of cobalt from sulfate media containing excess manganese by mixtures LIX63 and several amines was investigated. The addition of amines shifted cobalt extraction isotherm to higher pH region in all case.
Masatoshi TAKANO, Yoshitomo OZAKI, Satoshi ASANO, Yuzo BABA, Fukiko KUBOTA, Masahiro GOTO   +5 more
doaj   +1 more source

Manganese Catalyzed Oximation of Hydrocarbons to Oximes

Nature Communications
Abstract Oximes are used in many scientific and industrial domains, ranging from organic synthesis through biotechnology to materials science. Traditionally, their synthesis necessitates the use of hydrocarbons with specific functional groups, such as carbonyls, which are often more challenging and expensive to obtain compared to their ...
Menghui Song, Hong Li, Li Xie, Xiaoxin Zhang, Xiaotian Weilian, Rucao Wang, Alexander Steiner, Huaming Sun, Chao Wang, Jianliang Xiao, Chaoqun Li   +10 more
openaire   +2 more sources

Novel Group of AChE Reactivators—Synthesis, In Vitro Reactivation and Molecular Docking Study

Molecules, 2018
The acetylcholinesterase (AChE) reactivators (e.g., obidoxime, asoxime) became an essential part of organophosphorus (OP) poisoning treatment, together with atropine and diazepam.
David Malinak, Eugenie Nepovimova, Daniel Jun, Kamil Musilek, Kamil Kuca   +4 more
doaj   +1 more source

Oximes: Novel Therapeutics with Anticancer and Anti-Inflammatory Potential

Biomolecules, 2021
Oximes have been studied for decades because of their significant roles as acetylcholinesterase reactivators. Over the last twenty years, a large number of oximes have been reported with useful pharmaceutical properties, including compounds with ...
Igor A. Schepetkin, Mark B. Plotnikov, Andrei I. Khlebnikov, Tatiana M. Plotnikova, Mark T. Quinn   +4 more
doaj   +1 more source