Results 31 to 40 of about 30,052 (257)
Selamectin is the avermectin with the best potential for Buruli ulcer treatment [PDF]
, 2015 A comprehensive analysis was done to evaluate the potential use of anti-parasitic macrocyclic lactones (including avermectins and milbemycins) for Buruli ulcer (BU) therapy.
Gerd Pluschke +7 more
core +2 more sources
The Separation of Cobalt by Solvent Extraction Using Oxime-Amine Mixture System
Journal of MMIJ, 2017 Extraction behavior of cobalt from sulfate media containing excess manganese by mixtures LIX63 and several amines was investigated. The addition of amines shifted cobalt extraction isotherm to higher pH region in all case.
Masatoshi TAKANO +5 more
doaj +1 more source
Manganese Catalyzed Oximation of Hydrocarbons to Oximes
Nature CommunicationsAbstract Oximes are used in many scientific and industrial domains, ranging from organic synthesis through biotechnology to materials science. Traditionally, their synthesis necessitates the use of hydrocarbons with specific functional groups, such as carbonyls, which are often more challenging and expensive to obtain compared to their ...
Menghui Song +10 more
openaire +2 more sources
, 2023 Organophosphorous-based nerve agents remain one of the most toxic and accessible chemical warfare agents known to man. Herein, we report the development of novel, oxime-functionalized poly(4-vinylpyridine) (P4VP-Ox) materials as inexpensive, scalable ...
Busra Sonmez Baghirzade (10681775) +7 more
core +1 more source
Novel Group of AChE Reactivators—Synthesis, In Vitro Reactivation and Molecular Docking Study
Molecules, 2018 The acetylcholinesterase (AChE) reactivators (e.g., obidoxime, asoxime) became an essential part of organophosphorus (OP) poisoning treatment, together with atropine and diazepam.
David Malinak +4 more
doaj +1 more source
Oximes: Novel Therapeutics with Anticancer and Anti-Inflammatory Potential
Biomolecules, 2021 Oximes have been studied for decades because of their significant roles as acetylcholinesterase reactivators. Over the last twenty years, a large number of oximes have been reported with useful pharmaceutical properties, including compounds with ...
Igor A. Schepetkin +4 more
doaj +1 more source
Angewandte Chemie, EarlyView.Lenacapavir, the first‐in‐class drug targeting HIV‐1 capsid, is a breakthrough drug in HIV‐1 treatment and prophylaxis. However, a single M66I mutation confers complete viral resistance to lenacapavir. We report herein the design and synthesis of innovative R2 analogs demonstrating low nM potency against HIV‐1 M66I and excellent pharmacokinetics in ...
Nicolas Jamey +13 more
wiley +2 more sources
Amidoximes and Oximes: Synthesis, Structure, and Their Key Role as NO Donors
Molecules, 2019 Nitric oxide (NO) is naturally synthesized in the human body and presents many beneficial biological effects; in particular on the cardiovascular system.
Tanya Sahyoun +2 more
doaj +1 more source
Biomolecules, 2020 (1) Background: Human exposure to organophosphorus compounds employed as pesticides or as chemical warfare agents induces deleterious effects due to cholinesterase inhibition. One therapeutic approach is the reactivation of inhibited acetylcholinesterase
André-Guilhem Calas +18 more
doaj +1 more source
Post‐Synthetic Zinc Modifications to Correct Speciation in Ti‐MWW Zeolites for Catalytic Oxidation
Angewandte Chemie, EarlyView.Post‐synthetic Zn modifications of Ti‐MWW zeolite catalysts exhibit improved catalytic properties in the selective oxidation reaction, namely the ammoximation reaction. The origin of the beneficial effect of Zn is related via an array of spectroscopic and microscopic techniques to the modification of extra‐framework TiO2 and TiOx clusters and the ...
Christoph J. Kaul +10 more
wiley +2 more sources