Results 11 to 20 of about 3,919 (182)

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Dimethyl 2-(1-benzyl-2-oxoindolin-3-ylidene)-1,3-dithiole-4,5-dicarboxylate

Acta Crystallographica Section E, 2011
In the title compound, C22H17NO5S2, the dithiole and oxindole rings are almost coplanar [dihedral angle = 2.71 (8)°] and the phenyl ring makes a dihedral angle of 73.65 (5)° with the oxindole ring.
Ayoob Bazgir
doaj   +1 more source

Natural Corynanthe-Type Cholinesterase Inhibitors from Malaysian Uncaria attenuata Korth.: Isolation, Characterization, In Vitro and In Silico Studies

Metabolites, 2023
The Uncaria genus is notable for its therapeutic potential in treating age-related dementia, such as Alzheimer’s disease. A phytochemical study of the leaves of Malaysian Uncaria attenuata Korth., afforded an undescribed natural corynanthe-type oxindole ...
Nelson Jeng-Yeou Chear, Tan Ai Fein Ching-Ga, Kooi-Yeong Khaw, Francisco León, Wen-Nee Tan, Siti R. Yusof, Christopher R. McCurdy, Vikneswaran Murugaiyah, Surash Ramanathan   +8 more
doaj   +1 more source

Total synthesis of (±)-coerulescine and (±)-horsfiline

Beilstein Journal of Organic Chemistry, 2010
Wittig olefination–Claisen rearrangement protocol was applied to obtain 3-allyl oxindole. This oxindole was then converted to (±)-coerulescine and (±)-horsfiline.
Mukund G. Kulkarni, Attrimuni P. Dhondge, Sanjay W. Chavhan, Ajit S. Borhade, Yunnus B. Shaikh, Deekshaputra R. Birhade, Mayur P. Desai, Nagorao R. Dhatrak   +7 more
doaj   +1 more source

Methyl 3-[(1H-benzimidazol-1-yl)methyl]-1-methyl-4-(4-methylphenyl)-2′-oxopyrrolidine-2-spiro-3′-1-benzimidazole-3-carboxylate

Acta Crystallographica Section E, 2010
In the title compound, C29H28N4O3, the pyrrolidine ring adopts a twist conformation whereas the oxindole and benzimidazole residues are approximately planar with maximum deviations of 0.159 (1) and 0.011 (1) &#197 ...
S. Kathiravan, K. Ravikumar, B. Sridhar, S. Selvanayagam, R. Raghunathan   +4 more
doaj   +1 more source

Synthesis and Biological Evaluation of 5-Fluoro-2-Oxindole Derivatives as Potential α-Glucosidase Inhibitors

Frontiers in Chemistry, 2022
α-Glucosidase inhibitors are known to prevent the digestion of carbohydrates and reduce the impact of carbohydrates on blood glucose. To develop novel α-glucosidase inhibitors, a series of 5-fluoro-2-oxindole derivatives (3a ∼ 3v) were synthesized, and ...
Jing Lin, Qi-Ming Liang, Yuan-Na Ye, Di Xiao, Li Lu, Meng-Yue Li, Jian-Ping Li, Yu-Fei Zhang, Zhuang Xiong, Na Feng, Chen Li   +10 more
doaj   +1 more source

Tetrabutylammonium Iodide–Promoted Thiolation of Oxindoles Using Sulfonyl Chlorides as Sulfenylation Reagents

Molecules, 2017
3-Sulfanyloxindoles were synthesised by triphenylphosphine-mediated transition-metal-free thiolation of oxindoles using sulfonyl chlorides as sulfenylation reagents.
Xia Zhao, Aoqi Wei, Xiaoyu Lu, Kui Lu
doaj   +1 more source

GIF-2209, an Oxindole Derivative, Accelerates Melanogenesis and Melanosome Secretion via the Modification of Lysosomes in B16F10 Mouse Melanoma Cells

Molecules, 2021
Melanogenesis and melanosome secretion are regulated by several mechanisms. In this study, we found that the oxindole derivative GIF-2209 accelerated melanogenesis associated with the discrimination in the expression and intracellular distributions of ...
Miyu Watanabe, Kyoka Kawaguchi, Yusuke Nakamura, Kyoji Furuta, Hiroshi Takemori   +4 more
doaj   +1 more source

Literature Survey and Further Studies on the 3-Alkylation of N-Unprotected 3-Monosubstituted Oxindoles. Practical Synthesis of N-Unprotected 3,3-Disubstituted Oxindoles and Subsequent Transformations on the Aromatic Ring

Molecules, 2016
The paper provides a comprehensive review of the base-catalysed C3-alkylation of N-unprotected-3-monosubstituted oxindoles. Based on a few, non-systematic studies described in the literature using butyllithium as the deprotonating agent, an optimized ...
Eszter Kókai, Gyula Simig, Balázs Volk
doaj   +1 more source

Photochemical Aryl Radical Cyclizations to Give (E)-3-Ylideneoxindoles

Molecules, 2014
(E)-3-Ylideneoxindoles are prepared in methanol in reasonable to good yields, as adducts of photochemical 5-exo-trig of aryl radicals, in contrast to previously reported analogous radical cyclizations initiated by tris(trimethylsilyl)silane and azo ...
Michael Gurry, Ingrid Allart-Simon, Patrick McArdle, Stéphane Gérard, Janos Sapi, Fawaz Aldabbagh   +5 more
doaj   +1 more source