Results 121 to 130 of about 60,467 (293)

Functional Genomics Reveals Synthetic Lethality between Phosphogluconate Dehydrogenase and Oxidative Phosphorylation

Cell Reports, 2019
Summary: The plasticity of a preexisting regulatory circuit compromises the effectiveness of targeted therapies, and leveraging genetic vulnerabilities in cancer cells may overcome such adaptations.
Yuting Sun, Madhavi Bandi, Timothy Lofton, Melinda Smith, Christopher A. Bristow, Alessandro Carugo, Norma Rogers, Paul Leonard, Qing Chang, Robert Mullinax, Jing Han, Xi Shi, Sahil Seth, Brooke A. Meyers, Meredith Miller, Lili Miao, Xiaoyan Ma, Ningping Feng, Virginia Giuliani, Mary Geck Do, Barbara Czako, Wylie S. Palmer, Faika Mseeh, John M. Asara, Yongying Jiang, Pietro Morlacchi, Shuping Zhao, Michael Peoples, Trang N. Tieu, Marc O. Warmoes, Philip L. Lorenzi, Florian L. Muller, Ronald A. DePinho, Giulio F. Draetta, Carlo Toniatti, Philip Jones, Timothy P. Heffernan, Joseph R. Marszalek   +37 more
doaj   +1 more source

DADA Enhances CD8+ T Cell Stemness to Improve Anti‐Tumor Immunity and Immunotherapy Efficacy

Advanced Science, EarlyView.
Diisopropylamine dichloroacetate (DADA) enhances CD8+ T cell stemness by improving OXPHOS and mitochondrial fitness in a PDK1‐depenpendent manner. This metabolic shift strengthens CD8+ T cell anti‐tumor immunity, improves responses to PD‐1 blockade, and endows CAR‐T cells with prolonged persistence and resistance to terminal exhaustion, highlighting a ...
Mingyue Bi, Fei Li, Heng Jiang, Lingling Gu, Mengjie Sun, Kunyu Lu, Pianpian Liu, Ruyue Xie, Wenqiang Ma, Meijuan Zheng, Xianwei Wang, Xuefu Wang, Jingjing Cong   +12 more
wiley   +1 more source

Mitochondrial metabolism in Drosophila macrophage-like cells regulates body growth via modulation of cytokine and insulin signaling

Biology Open, 2023
Shrivani Sriskanthadevan-Pirahas, Abdul Qadeer Tinwala, Michael J. Turingan, Shahoon Khan, Savraj S. Grewal   +4 more
doaj   +1 more source

Inhibition of OXPHOS induces metabolic rewiring and reduces hypoxia in murine tumor models

Clinical and Translational Radiation Oncology
Introduction: Tumor hypoxia is a feature of many solid malignancies and is known to cause radio resistance. In recent years it has become clear that hypoxic tumor regions also foster an immunosuppressive phenotype and are involved in immunotherapy ...
Daan F. Boreel, Anne P.M. Beerkens, Sandra Heskamp, Milou Boswinkel, Johannes P.W. Peters, Gosse J. Adema, Paul N. Span, Johan Bussink   +7 more
doaj   +1 more source

Mitophagy and Ubiquitination Coordinate Context‐Specific Mitochondrial Quality Control and EMT/MET Plasticity to Drive Cancer Cell Invasion

Advanced Science, EarlyView.
Metastatic invasion emerges when tumor‐intrinsic programs and microenvironmental forces converge on mitochondrial quality control. A context‐stratified framework links mtROS, mtDNA integrity, mechanics and nutrient/oxygen cues to fission–fusion remodeling, mtUPR and mitophagy.
Bin‐Hsu Mao, Bo‐Kai Su, Ying‐Jan Wang, Ting‐Yuan Tu   +3 more
wiley   +1 more source

Oxidative phosphorylation at the crossroads of cancer: Metabolic orchestration, stromal collusion, and emerging therapeutic horizons

Interdisciplinary Medicine
Oxidative phosphorylation (OXPHOS) plays a complex and dynamic role in cancer biology, with its involvement varying depending on tumor type, cancer progression stage, and microenvironmental conditions.
Keke Chen, Bo Wang, Hongying Shu, Jianxin Lyu, Wei Cui, Hezhi Fang   +5 more
doaj   +1 more source

OXPHOS inhibition overcomes chemoresistance in triple negative breast cancer

Redox Biology
The hypothesis of a significant shift from oxidative phosphorylation (OXPHOS) to glycolysis in a number of solid tumors has been dominant for many years.
Cemile Uslu, Eda Kapan, Alex Lyakhovich
doaj   +1 more source

Dieta cetogénica y enfermedad OXPHOS

, 2021
Las dietas cetogénicas (KD), tanto la KD clásica como sus modificaciones, están caracterizadas por un alto consumo de grasas y bajo de carbohidratos, imitando los cambios metabólicos que se producen durante la inanición. Este tipo de dietas se han comenzado a utilizar para tratar enfermedades metabólicas derivadas de mutaciones mitocondriales, como es ...
Fernández Caudevilla, Mª Cinta, Ruiz Pesini, Eduardo   +1 more
openaire   +1 more source

OXPHOS gene expression and control in mitochondrial disorders

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2009
The cellular consequences of deficiencies of the mitochondrial OXPHOS system include a variety of direct and secondary changes in metabolite homeostasis, such as ROS, Ca(2+), ADP/ATP, and NAD/NADH. The adaptive responses to these changes include the transcriptional responses of nuclear and mitochondrial genes that are mediated by these metabolites ...
Reinecke, F., Smeitink, J.A.M., Smeitink, J.A.M., van der Westhuizen, F.H.   +3 more
openaire   +3 more sources

TRAP5 Inhibition Targeting Scar‐Associated Macrophages Ameliorates Acute Kidney Injury to Chronic Kidney Disease Transition

Advanced Science, EarlyView.
This study delineates macrophage heterogeneity along the acute kidney injury to chronic kidney disease transition. Single‐cell RNA sequencing reveals a TRAP5+ scar‐associated macrophage subset driven by Spp1–Cd44 signaling and mitochondrial metabolic reprogramming.
Chenxi Wang, Yaodong Gu, Wen Du, Lin Xie, Jinwei Quan, Yu Zhao, Ye Cheng, Zhaonan Wei, Yuanyuan Sha, Yi Wang, Dechao Xu, Xiang Gao, Min Chen, Xiangchen Gu   +13 more
wiley   +1 more source