Results 221 to 230 of about 60,467 (293)

Targeting mitochondrial homeostasis as a cancer treatment strategy: current status and future prospects. [PDF]

Mol Cancer
Zhong H, Pan R, Ouyang Y, Xiao T, Gu W, Yang H, Wang H, Li H, Peng T, Chen P.   +9 more
europepmc   +1 more source

Mitochondrial respiration and hydrogen peroxide production rate in right atrial tissues from obese diabetic patients

Experimental Physiology, EarlyView.
Abstract Type 2 diabetes (T2D) is a global epidemic, with heart failure being the leading cause of premature death. Mitochondrial dysfunction, characterized by impaired energy metabolism, weakened energy transport system and increased oxidative stress, has been proposed as a key contributor to the impairment of contractile function in T2D hearts ...
Toan Pham, Sarbjot Kaur, Anthony Hickey, Marie‐Louise Ward, Kenneth Tran   +4 more
wiley   +1 more source

M2 macrophages and tumor cells engage in a metabolic feedback loop to drive HCC progression. [PDF]

Sci Rep
Nong Y, Chen X, Zhang B, Lin Z, Wuriniletu, Du C, Liu Q.   +6 more
europepmc   +1 more source

Sex‐dependent effects of a high‐fat diet‐induced obesity model on cerebrovascular health and brain metabolism

Experimental Physiology, EarlyView.
Abstract Mid‐life obesity is a major risk factor for neurodegenerative diseases, with mitochondrial and cerebrovascular dysfunction considered key mediators. Lysine acetylation is a reversible post‐translational modification that regulates several mitochondrial metabolic and biochemical processes.
Nicole N. Eminhizer, Dena Lin, Alec Hanshew, Jackson Stewart, Steven Ball, Christa Lilly, Saina S. Prabhu, Kate Karelina, Eric E. Kelley, Randy W. Bryner, Dharendra Thapa, Paul D. Chantler   +11 more
wiley   +1 more source

Mitochondrial Redox Vulnerabilities in Triple-Negative Breast Cancer: Integrative Perspectives and Emerging Therapeutic Strategies. [PDF]

Metabolites
Cruz-Gregorio A.
europepmc   +1 more source

Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney, Vincent Marcangeli, Krystel Desjardins, Shima Taherkhani, Gilles Gouspillou   +4 more
wiley   +1 more source

Androgen Receptors Promote Oxidative Phosphorylation and Resistance to Palmitate Lipotoxicity in ER-Mutant Breast Cancer.

Endocrinology
Sessions DT, Boulton DP, Spoelstra NS, Caino MC, Yu M, Goodspeed A, Richer JK.   +6 more
europepmc   +1 more source

Deficiency of Microglial-Derived Spp1 Exacerbates Age-Related Memory Decline by Impairing Mitochondrial Complex I Function. [PDF]

Aging Cell
Wang M, Chang Y, He A, Yang J, Li A, Wang H, Lim KL, Guo X, Zhang C, Lu L.   +9 more
europepmc   +1 more source

Calciprotein particle‐induced calcium overload triggers mitochondrial dysfunction in endothelial cells

The Journal of Physiology, EarlyView.
Abstract figure legend Calciprotein particles (CPPs) are small calcium‐ and phosphate‐containing nanoaggregates associated with the development of vascular disease (CVD) in chronic kidney disease (CKD). Previously, we have shown that CPPs induce endothelial cell (EC) dysfunction, possibly contributing to CVD in CKD, but the underlying molecular ...
Lian Feenstra, Laurent Chatre, Benoit Bernay, Julien Pontin, Mirjam F. Mastik, Azuwerus van Buiten, Dalibor Nakládal, Bastiaan S. Star, Jan‐Luuk Hillebrands, Guido Krenning   +9 more
wiley   +1 more source