Results 121 to 130 of about 27,463 (211)

RORA Targeting PRNP Modulates Age‐Related Cataract via Activation Oxidative Injury‐Induced Cellular Senescence and Apoptosis of Lens Epithelial Cells

Aging Cell, Volume 25, Issue 6, June 2026.
The molecular mechanisms of RORA targeting PRNP activate oxidative injury‐induced cellular senescence and apoptosis of lens epithelial cells. Current research confirms that the transcription factor RORA targets PRNP, exacerbating cellular senescence and apoptosis of LECs (Figure 7).
Yue Zou, Wanqian Li, Jiaojiao Zhang, Chao Cen, Wanqiu Zheng, Ruonan Li, Hong Cheng, Liang Liang, Juan Kang, Wenjuan Wan, Ke Hu, Shijie Zheng   +11 more
wiley   +1 more source

Novel Function of Nogo-A as Negative Regulator of Endothelial Progenitor Cell Angiogenic Activity: Impact in Oxygen-Induced Retinopathy. [PDF]

Int J Mol Sci, 2023
Ruknudin P, Nazari AR, Wirth M, Lahaie I, Bajon E, Rivard A, Chemtob S, Desjarlais M.   +7 more
europepmc   +1 more source

Protective Effect of Vitamin E Against Vancomycin‐Induced Nephrotoxicity: A Large‐Scale Electronic Medical Record Study From Japan

Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 6, June 2026.
ABSTRACT Vancomycin (VCM) is essential for treating methicillin‐resistant Staphylococcus aureus infections, but its use is limited by vancomycin‐induced nephrotoxicity (VIN). Although preclinical and small clinical studies suggest a protective role for vitamin E, real‐world evidence remains limited.
Satoru Nakanishi, Shungo Imai, Megumi Saito, Hayato Kizaki, Haru Iino, Masami Tsuchiya, Satoko Hori   +6 more
wiley   +1 more source

Anti-VEGF therapy in the management of retinopathy of prematurity: what we learn from representative animal models of oxygen-induced retinopathy

Eye and Brain, 2016
Haibo Wang Department of Ophthalmology, John A Moran Eye Center, The University of Utah, Salt Lake City, UT, USA Abstract: Retinopathy of prematurity (ROP) remains a leading cause of childhood blindness, affecting infants born prematurely.
Wang H
doaj  

Prenatal Carotenoid Supplementation With Lutein or Zeaxanthin Ameliorates Oxygen-Induced Retinopathy (OIR) in Bco2-/- Macular Pigment Mice. [PDF]

Invest Ophthalmol Vis Sci, 2023
Arunkumar R, Li B, Addo EK, Hartnett ME, Bernstein PS.   +4 more
europepmc   +1 more source

Predictors of Exercise Performance in Type 1 Diabetes: The Role of Hypoglycaemia Fear, Glycaemic Control, and Vascular Health: A Retrospective Cross‐Sectional Study

Diabetes, Obesity and Metabolism, Volume 28, Issue 6, Page 5229-5239, June 2026.
ABSTRACT Aim Cardiorespiratory fitness is often impaired in individuals with type 1 diabetes. While physiological determinants have been studied, psychological barriers such as fear of hypoglycaemia remain underexplored. We hypothesised that glycaemic factors including HbA1c, diabetes duration, the presence of microvascular complications, and fear of ...
Arne Kooistra, Klaske van Kammen, Isabel Bekker, Peter R. van Dijk, Helen L. Lutgers, Rienk Dekker, André P. van Beek   +6 more
wiley   +1 more source

Effect of light on oxygen-induced retinopathy in the mouse.

Investigative ophthalmology & visual science, 1994
To examine the effect lf light on retinal neovascularization and vasculogenesis in a reproducible and quantifiable model of oxygen-induced proliferative retinopathy in the mouse.C57Bl/6J mice were reared in room air, 68% oxygen, or 75% oxygen and were exposed to darkness, low cyclical light (200-350 lux), or high-intensity continuous light (3000-4500 ...
E, Wesolowski, L E, Smith
openaire   +1 more source

Unveiling protective mechanisms of wild olive (acebuche) oil in retinal pigment epithelial cells with hypertensive phenotype

The Journal of Physiology, Volume 604, Issue 11, Page 4166-4185, 1 June 2026.
Abstract figure legend Circulating extracellular vesicles (EVs) derived from acebuche (ACE) oil‐ and extra virgin olive oil (EVOO)‐fed mice modulate nitric oxide (NO) metabolism in the retinal pigment epithelial cell line (ARPE19) with a hypertensive phenotype induced by angiotensin II (AngII).
Álvaro Santana‐Garrido, Claudia Reyes‐Goya, Pablo Espinosa‐Martín, Rosa M. Troya‐Toledo, Helder André, Alfonso Mate, Carmen M. Vázquez   +6 more
wiley   +1 more source

Irisin Attenuates Pathological Neovascularization in Oxygen-Induced Retinopathy Mice. [PDF]

Invest Ophthalmol Vis Sci, 2022
Zhang J, Liu Z, Wu H, Chen X, Hu Q, Li X, Luo L, Ye S, Ye J.   +8 more
europepmc   +1 more source

Heterogeneous metabolic response of endothelial cells from different vascular beds to experimental hyperglycaemia and metformin

The Journal of Physiology, Volume 604, Issue 11, Page 4208-4224, 1 June 2026.
Abstract figure legend Diabetes mellitus is associated with vascular pathology that leads to vascular complications in several tissues, such as retinopathy of the eye. Endothelial dysfunction plays a pivotal role in the progression of each complication.
C. McAleese, G. Joudah, I. P. Salt, J. R. Petrie, J. M. Leiper, Laura B. Dowsett   +5 more
wiley   +1 more source