Results 111 to 120 of about 5,246,984 (361)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Mitophagy-Inducing Nanocarriers Restore Mitochondrial Quality and Cell Functions in Senescent Retinal Pigment Epithelial Cells

Oxygen
Age-related macular degeneration (AMD) is an age-associated disease characterized by damage to the central retina and represents a leading cause of acquired blindness, with increasing prevalence in aging populations.
Rinko Aso, Kohei Shibusawa, Sogo Aoki, Kiyoshi Sato, Hiroyoshi Kawakami   +4 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Design and Synthesis of Fused Derivatives of 7-Hydroxycoumarin (Umbelliferone) with the Flavonol Quercetin and the Flavone Luteolin-Analysis of Their Antioxidant and Physicochemical Properties

Oxygen
Oxidative stress seems to be part of many deranged processes in the organism, affecting multiple degenerative conditions at a cellular and tissue level.
Panagiotis Theodosis-Nobelos, Georgios Papagiouvannis, Maria Fesatidou, Gabriel Marc, Athina Geronikaki, Boris Lichitsky, Victor Kartsev, Andrey Komogortsev, Samvel Sirakanyan   +8 more
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Hydroperoxides: Plant Steroids and Triterpenoids as Promising Candidates for Anti-Dementia Therapy

Oxygen
Hydroperoxides (R–OOH, organic hydroperoxides) constitute a relatively small but structurally diverse class of natural metabolites occurring in higher plants, fungi, and marine organisms.
Valery M. Dembitsky, Alexander O. Terent’ev   +1 more
doaj   +1 more source

Multiple Outlet Oxygen Unit Advertisement

, 1965
This double-sided sheet advertises a multi-user oxygen unit recommended for use in family fallout shelters. The ad copy states that "Their primary value would be for the inhalation of oxygen during the firestorm that inevitably rages following the blast."
Columbus Oxygen Company
core  

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Walter Brant II, Third Generation

, 1970
In 1979, Walter “Wally” Brant II, Robert’s son, joined Indiana Oxygen, after graduating from Purdue and later serving as a Navigator on a B-52 combat crew during the Vietnam War.

core  

Oxygen supply and consumption in soilless culture: evaluation of an oxygen simulation model for cucumber [PDF]

, 2001
A soil oxygen simulation model (OXSI) was tested and evaluated for evaluating growing media with respect to aeration. In the model, local oxygen concentrations are calculated from coefficients of diffusion and consumption (respiration), assuming ...
Baas, R., Koolen, A.J., Stol, K.J., Wever, G., Tariku, E.   +4 more
core   +1 more source