Results 101 to 110 of about 5,246,984 (361)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

HIF-1α Signaling in Uterine Fibroids: A Central Integrator of Hypoxic, Hormonal, and Fibrotic Pathways

Oxygen
Uterine fibroids (leiomyomas) are common benign smooth muscle tumors that impose substantial symptom burden and healthcare costs worldwide. Although uterine fibroid (leiomyoma) pathogenesis is multifactorial, hypoxia has emerged as a key feature of the ...
Sruthi Tatavarthi, Valentina Vanos, Abigail Lepsch Combs, Alvina Pan, Mahita Saini, Mostafa A. Borahay   +5 more
doaj   +1 more source

REACTIVE OXYGEN SPECIES, CELLULAR REDOX SYSTEMS AND APOPTOSIS

Free Radical Biology & Medicine, 2010
Reactive oxygen species (ROS) are products of normal metabolism and xenobiotic exposure, and depending on concentrations, ROS can be beneficial or harmful to cells and tissues.
M. Circu, T. Aw
semanticscholar   +1 more source

Imaging Oxygen Distribution in Marine Sediments. The Importance of Bioturbation and Sediment Heterogeneity [PDF]

, 2008
The influence of sediment oxygen heterogeneity, due to bioturbation, on diffusive oxygen flux was investigated. Laboratory experiments were carried out with 3 macrobenthic species presenting different bioturbation behaviour patterns:the polychaetes ...
Poggiale, Jean-Christophe, Cuny, Philippe, Gilbert, Franck, Pischedda, Laura   +3 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Targeting Catechol Oxidation via Boron Complexation: From Chemistry to Biology

Oxygen
Catechol (benzene-1,2-diol) is a highly versatile chemical motif that plays a central role in both terrestrial and marine systems, where its reactivity is governed by a combination of enzymatic oxidation and non-enzymatic interactions.
Valery M. Dembitsky, Alexander O. Terent’ev, Sergey V. Baranin   +2 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Methemoglobin Activity Might Explain Rapid Increase in Oxygen Saturation Among COVID-19 Patients Healed with Chlorine Dioxide Gas in Solution

Oxygen
Chlorine dioxide (ClO2) is a neutral oxidant molecule with a short lifespan once in contact with electron donors (organic matter). ClO2 solutions have antiviral, antibacterial, antifungal, anti-protozoan, anti-inflammatory, anticancer, and wound-healing ...
Enrique A. Martinez Mosqueira, Pierrick Martinez, Manuel Aparicio-Alonso, Antonio Vega-Galvez   +3 more
doaj   +1 more source

Oxygen prescription and administration at the Emergency Department and medical wards in Mater Dei Hospital [PDF]

, 2011
Aims: The aim of this study was to audit current practices on oxygen prescription in the Emergency Department (ED), and on accurate oxygen administration in the wards of Mater Dei Hospital. Method: Two hundred and forty eight adult patients attending the
Fenech, Valerie Anne, Gatt, Jurgen, Montefort, Stephen, Asciak, Rachelle   +3 more
core  

Oxygen isotope ecology of recent planktic foraminifera at the central Walvis Ridge (SE Atlantic) [PDF]

, 2005
Above the Walvis Ridge, in the SE Atlantic Ocean, we collected living plantkic foraminifera from the upper water column using depth stratified plantkon tows. The oxygen isotope composition (
Kroon, Dirk, Dick Kroon, Brummer, G.J.A., Neven Lončarić, Brummer, G. J. A., Kroon, D., Peeters, F. J. C., Peeters, F.J.C., Geert‐Jan A. Brummer, Loncaric, N., Frank J. C. Peeters   +10 more
core   +1 more source