Results 81 to 90 of about 1,904,615 (269)

A Simplified 3D-Plasma Culture Method for Generating Minimally Manipulated Autologous Equine Muscle-Derived Progenitor Cells

Bio-Protocol
Musculoskeletal pathologies present challenges in athletic horses, often leading to functional impairment. The slow or limited regenerative capacity of bone, joint, and tendon/ligament injuries, coupled with the limitations of conventional treatments ...
Hélène Graide, Julien Duysens, Thierry Frank, Ange Mouithys-Mickalad, Ariane Niesten, Charlotte Sandersen, Justine Ceusters, Didier Serteyn   +7 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

IL-17 + γδT cell: a new target in hyperbaric oxygen treatment reducing spinal cord injury

Journal of Translational Medicine
Background Hyperbaric oxygen (HBO) treatment can attenuate the inflammatory response after spinal cord injury (SCI), but the specific molecular mechanisms are unclear. γδT cells have emerged as key immune regulatory cells.
Mo Liu, Zhencheng Sun, Fang Liang, Ruizhang Yao, Lu Yang, Ding Nan, Jing Yang, Qingjun Su, Xuehua Liu   +8 more
doaj   +1 more source

Ti³⁺ Self-Doping of TiO₂ Boosts Its Photocatalytic Performance: A Synergistic Mechanism

Molecules
Pollution remains one of the most significant global challenges. Photocatalysis consists of a new organic pollutant removal technology, with TiO2 widely studied as a photocatalyst in the photocatalytic removal of water pollution.
Mingqing Zhang, Manyu Liu, Keyi Han, Yingbin Liang, Xinyu Zhao, Lin Han, Jinnong Wang, Shifeng Wang, Yong Li   +8 more
doaj   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Oxygen [PDF]

Bone Marrow Transplantation, 2020
openaire   +2 more sources

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Hyperbaric oxygen therapy services at the Pamela Youde Nethersole Eastern Hospital hyperbaric oxygen therapy Center: A retrospective epidemiological study

Hong Kong Journal of Emergency Medicine
Introduction The aim of this retrospective epidemiological study is to analyze the characteristics and caseload of patients treated at the Pamela Youde Nethersole Eastern Hospital (PYNEH) hyperbaric oxygen therapy (HBOT) Center in Hong Kong from 2018 to ...
Kin Bong Tang, Hiu Kwan Suen, Wing Wa Yan   +2 more
doaj   +1 more source

Hypoxia in Uterine Fibroids: Role in Pathobiology and Therapeutic Opportunities

Oxygen
Uterine fibroids are the most common tumors in females, affecting up to 70% of women worldwide, yet targeted therapeutic options are limited. Oxidative stress has recently surfaced as a key driver of fibroid pathogenesis and provides insights into ...
Sydney L. Olson, Razeen J. Akbar, Adrianna Gorniak, Laura I. Fuhr, Mostafa A. Borahay   +4 more
doaj   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source