Results 61 to 70 of about 3,098,273 (304)

Spatial oxygen heterogeneity in a Hediste diversicolor irrigated burrow [PDF]

, 2011
The heterogeneity of oxygen distribution in a Hediste diversicolor burrow environment was investigated in a laboratory experiment using a 6-mm thick tank equipped with oxygen planar optodes. The twodimensional oxygen distribution in a complete burrow was
Franck Gilbert, Poggiale, Jean-Christophe, Cuny, Philippe, Esteves, José Luis, Philippe Cuny, José Luis Esteves, Gilbert, Franck, Laura Pischedda, Jean-Christophe Poggiale, Pischedda, Laura, Esteves, Josã© Luis, Poggiale, Jean Christophe   +11 more
core   +1 more source

Extraction of Bioactive Compounds from Cistus creticus Leaves and Their Use in the Preparation of Yogurt Desserts

Oxygen
The objective of this study was to determine the optimal conditions for the recovery of bioactive and antioxidant compounds in aqueous solutions of Cistus creticus leaves and then employ the optimal extract for the enrichment of yogurt samples.
Dimitrios Palaiogiannis, Vassilis Athanasiadis, Theodoros Chatzimitakos, Martha Mantiniotou, Eleni Bozinou, Dimitris P. Makris, Stavros I. Lalas   +6 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Hyperoxia reversibly alters oxygen consumption and metabolism [PDF]

, 2012
Aim: Ventilation with pure oxygen (hyperoxic ventilation: HV) is thought to decrease whole body oxygen consumption (VO(2)). However, the validity and impact of this phenomenon remain ambiguous; until now, under hyperoxic conditions, VO(2) has only been ...
Lauscher, Patrick, Sabine Lauscher, Habler, Oliver, Kertscho, Harry, Patrick Lauscher, Lauscher, Sabine, Oliver Habler, Jens Meier, Meier, Jens, Harry Kertscho   +9 more
core   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Ambulatory oxygen: why do COPD patients not use their portable systems as prescribed? A qualitative study [PDF]

, 2011
Background: patients with COPD on long term oxygen therapy frequently do not adhere to their prescription, and they frequently do not use their ambulatory oxygen systems as intended. Reasons for this lack of adherence are not known. The aim of this study
Arnold, Elizabeth, Donovan-Hall, M, Elizabeth Arnold, Maggie Donovan-Hall, Dibb, Bridget, Fenwick, A, Fenwick Angela, Anne Bruton, Donovan-Hall Maggie, Fenwick, Angela, Arnold Elizabeth, Dibb, B, Walker Elizabeth, Bruton Anne, Walker, E, Elizabeth Walker, Walker, Elizabeth, Bruton, Anne, Bridget Dibb, Arnold, E, Angela Fenwick, Donovan-Hall, Maggie, Bruton, A, Dibb Bridget   +23 more
core   +2 more sources

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Energy Metabolism as a Therapeutic Target in Cancer: The Role of Coenzyme Q10

Oxygen
The generation of energy within cells is a fundamental process enabling cell survival, and as such it represents a potential target in cancer therapy.
David Mantle, Hannah Rowbottom, Jacob Jones, Indiia Margarita Potts, Nadia Turton, Mollie Dewsbury, Guillermo Lopez-Lluch, Iain P. Hargreaves   +7 more
doaj   +1 more source