Results 81 to 90 of about 3,692,732 (322)

CD11b+CD43hiLy6Clo splenocyte‐derived macrophages exacerbate liver fibrosis via spleen–liver axis

Hepatology, EarlyView., 2022
A population of splenic monocytes migrate into the liver and shift to macrophages, which account for the exacerbation of liver fibrosis. Abstract Background and Aims Monocyte‐derived macrophages (MoMFs), a dominant population of hepatic macrophages under inflammation, play a crucial role in liver fibrosis progression.
Shaoying Zhang, Dan Wan, Mengchen Zhu, Guihu Wang, Xurui Zhang, Na Huang, Jian Zhang, Chongyu Zhang, Qi Shang, Chen Zhang, Xi Liu, Fanfan Liang, Chunyan Zhang, Guangyao Kong, Jing Geng, Libo Yao, Shemin Lu, Yongyan Chen, Zongfang Li   +18 more
wiley   +1 more source

inhalation model

, 2023
271284Objectives: An integrated in vitro inhalation approach was outlined to estimate potential adverse acute inhalation effects of aerosols from commercial nebulizer applications used for purposeful room conditioning such as disinfection, scenting or ...
Detlef Ritter, Knebel, Jan, Rolf Fautz, Fautz, Rolf, Katharina Schwarz, Anne Zifle, Anne Fuchs, Ritter, Detlef, Tanja Hansen, Schwarz, Katharina, Fuchs, Anne, Jan Knebel, Hansen, Tanja, Zifle, Anne   +13 more
core   +1 more source

ICONIC study—conservative versus conventional oxygenation targets in intensive care patients: study protocol for a randomized clinical trial

Trials, 2022
Background Oxygen therapy is a widely used intervention in acutely ill patients in the intensive care unit (ICU). It is established that not only hypoxia, but also prolonged hyperoxia is associated with poor patient-centered outcomes.
C. C. A. Grim, L. I. van der Wal, H. J. F. Helmerhorst, D. J. van Westerloo, P. Pelosi, M. J. Schultz, E. de Jonge, for the ICONIC Investigators and PROVE Network   +7 more
doaj   +1 more source

Nano‐Backpack Engineered Probiotics with Reactive Oxygen Species–Responsive Tungsten Release for Synergistic Therapy of Inflammatory Bowel Disease

Advanced Science, EarlyView.
An integrated probiotic system is engineered to execute a programmed therapeutic cascade against inflammatory bowel disease. Upon pathological signals, the system sequentially performs ROS scavenging, tungsten release, and selective pathogen suppression, thereby breaking the oxidative stress–dysbiosis cycle to remodel gut microbiota and reinforce ...
Yang Yang, Liucan Wang, Guoqing Chen, Yuanling Zhang, Jiarui Shi, Wenzhe Fan, Min Yu, Jixi Zhang, Hua Yang   +8 more
wiley   +1 more source

The biological effects of subacute inhalation of diesel exhaust following addition of cerium oxide nanoparticles in atherosclerosis-prone mice [PDF]

, 2012
Background: Ceriumoxide(CeO2) nano particles improve the burning efficiency of fuel,however,little is known about health impacts of altered emissions from the vehicles.Methods: Atherosclerosis-prone apolipoprotein Eknockout (ApoE/) mice were exposed by ...
Boere, A. John F., Cassee, Flemming R., Miller, Mark R., Mclean, Steven G., Campbell, Arezoo, Duffin, Rodger, Gosens, Ilse, Krystek, Petra   +7 more
core   +1 more source

The E3 Ubiquitin Ligase RLIM Safeguards Oligodendrocyte Development and Myelination by Targeting SLC7A11 for Polyubiquitination to Regulate Ferroptotic Resistance

Advanced Science, EarlyView.
RLIM‐mediated SLC7A11 polyubiquitination is required for SPTBN2‐mediated trafficking and membrane localization of SLC7A11, which enables oligodendrocyte precursor cells to be resistant to ferroptosis and safeguards oligodendrocyte lineage progression and thus myelination.
Yuwei Li, Haijun Zhang, Jieya Zhou, Shiyu Yang, Jingmei Cha, Gaofeng Yan, Shuhua Zhao, Bingyu Mao, Pengcheng Ma   +8 more
wiley   +1 more source

Influence of Adjuvant Hyperbaric Oxygen Therapy on Short-term Complications During Surgical Reconstruction of Upper and Lower Extremity War Injuries: Retrospective Cohort Study [PDF]

, 2008
Cilj Odrediti utjecaj liječenja hiperbaričnom oksigenacijom (HBO) na kratkoročne komplikacije složenih ratnih ozljeda gornjih i donjih udova u ranjenika koji su bili i koji nisu bili liječeni u skladu s kirurškom strategijom Organizacije Sjeverno ...
Petričević, Ante, Čapkun, Vesna, Roje, Željka, Eterović, Davor, Roje, Tinka, Roje, Zdravko, Družijanić, Nikica   +6 more
core   +1 more source

Monitoring pulmonary rehabilitation and long-term oxygen therapy for people with chronic obstructive pulmonary disease (COPD) [PDF]

, 2013
This report outlines a proposed approach to monitoring access to, and utilisation of, pulmonary rehabilitation and long term oxygen therapy, by capitalising on existing data sources and identifying data development opportunities.SummaryChronic ...
Guy Marks
core  

A statistical evaluation of the effects of gender differences in assessment of acute inhalation toxicity [PDF]

, 2011
Acute inhalation toxicity of chemicals has conventionally been assessed by the median lethal concentration (LC50) test (organisation for economic co-operation and development (OECD) TG 403).
Price, Charlotte, Indans, Ian, Creton, S, Griffiths, Diane, Guest, R, Edwards, P, Griffiths, David, Stallard, Nigel, Creton, Stuart, Stallard, N, Indans, I, Price, Charlotte L, Edwards, Philippa, Guest, Robert   +13 more
core   +1 more source

S100A8/A9‐High Macrophages Activate Intestinal Fibroblasts via mCCL6/hCCL15‐CCR1 Axis to Drive Intestinal Fibrosis in Crohn's Disease

Advanced Science, EarlyView.
S100A8/A9‐high macrophages are markedly enriched in the stenotic intestinal tissue of patients with Crohn's disease. These profibrotic macrophages secrete mCCL6 in a STAT3‐dependent manner. mCCL6 and its human ortholog hCCL15 activate fibroblasts via the CCR1 receptor, thereby driving excessive collagen deposition.
Shu Wang, Jiayun Wang, Junjie Lin, Ziping Ye, Geyujia Zhou, Jingjing Ma, Junjian Sun, Jiang Yu, Yingdi Zhang, Nana Tang, Chunhua Jiao, Xiaojing Zhao, Hongjie Zhang   +12 more
wiley   +1 more source