Results 101 to 110 of about 85,537 (314)

Legumain Restrains Granuloma Formation by Inhibiting mTORC1/STAT1‐Mediated M1 Macrophage Polarization in Sarcoidosis

open access: yesAdvanced Science, EarlyView.
Legumain (LGMN) is upregulated in macrophages during sarcoid‑like granuloma formation. Macrophage‑derived LGMN binds to integrin αvβ3 and suppresses mTORC1/STAT1 signaling to restrain M1 macrophage polarization. Intratracheal delivery of lipid nanoparticles carrying Lgmn plasmid DNA (pDNA) elevates LGMN expression and effectively attenuates pulmonary ...
Mengyuan Liu   +12 more
wiley   +1 more source

Adecuada prescripción clínica de la oxigenoterapia continua domiciliaria

open access: yesRevista Electrónica Dr. Zoilo E. Marinello Vidaurreta, 2015
Los gases medicinales forman parte del conjunto de medicamentos utilizados en el adecuado tratamiento de las enfermedades, por lo que su prescripción se ha de realizar con la misma precisión y cuidado que con el resto de los medicamentos. La finalidad de
Sarah María Regueira Betancourt   +2 more
doaj  

Carbon Monoxide Exposure and Human Health [PDF]

open access: yes, 1975
The primary objective of this report is to provide detailed information on the health effects of carbon monoxide. With this information, the community can judge for itself what action is deemed necessary to maintain or improve the health of its ...
Joy, Richard W.   +2 more
core  

His+ reversions Caused in Salmonella typhimurium by different types of ionizing radiation [PDF]

open access: yes, 1988
The yield of his+ reversions in the Ames Salmonella tester strain TA2638 has been determined for 60Co γ rays, 140 kV X rays, 5.4 keV characteristic X rays, 2.2 MeV protons, 3.1 MeV α particles, and 18 MeV/U Fe ions.
Fitzek, M.   +3 more
core   +1 more source

Endogenous Ceramide 24:1 Constrains Th17‐Driven Neutrophilic Inflammation by Antagonizing EP2 Signaling

open access: yesAdvanced Science, EarlyView.
Cer24:1 levels are reduced in neutrophilic asthma and inversely correlate with disease severity and airway neutrophilia. Restoring Cer24:1 suppresses pathogenic Th17 differentiation by engaging EP2 on CD4+ T cells, thereby dampening the JAK2–STAT3–RORγt axis and reducing IL‐17 production.
Huan Liu   +11 more
wiley   +1 more source

Titration of oxygen therapy in critically ill emergency department patients: a feasibility study

open access: yesBMC Emergency Medicine, 2018
Background Liberal use of oxygen in an emergency situation is common. Today, most health care professionals do not adjust the amount of oxygen given when a saturation of 100% or a PaO2 which exceeds the normal range is reached- which may result in ...
Anna S. M. Dobbe   +3 more
doaj   +1 more source

Inhaled PGE1 in neonates with hypoxemic respiratory failure: two pilot feasibility randomized clinical trials. [PDF]

open access: yes, 2014
BackgroundInhaled nitric oxide (INO), a selective pulmonary vasodilator, has revolutionized the treatment of neonatal hypoxemic respiratory failure (NHRF). However, there is lack of sustained improvement in 30 to 46% of infants.
Ambalavanan, Namasivayam   +18 more
core   +2 more sources

A Circuit of Mechanically Regulated Transcription Factors Balances Regenerative and Fibrotic Memory of Mesenchymal Stromal Cells

open access: yesAdvanced Science, EarlyView.
Producing MSCs on rigid culture substrates induces a scar‐making phenotype, jeapordizing therapeutic success. ‘Tissue‐soft’ surfaces prevent MSC fibrogenesis and preserve regenerative traits. An epigenetic network, driven by HOXA11 and SALL1, maintains ‘soft memory’ by keeping chromatin open in relaxed MSCs, promoting anti‐fibrotic programs.
Fereshteh Sadat Younesi   +7 more
wiley   +1 more source

VALIDAÇÃO DOS PROCESSOS DE LIMPEZA E DESINFECÇÃO DOS ARTIGOS DE INALOTERAPIA E OXIGENOTERAPIA

open access: yesCogitare Enfermagem, 2002
Apresenta-se uma revisão bibliográfica sobre os principais aspectos relacionados aos processos de limpeza e desinfecção de artigos de inaloterapia e oxigenoterapia.
Rubens Griep, Marister Picolli
doaj   +1 more source

Palliative management of refractory dyspnea in COPD [PDF]

open access: yes, 2006
Auckland, New ...
Currow, David Christopher   +2 more
core  

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