Results 131 to 140 of about 38,938 (333)

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy

Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley   +1 more source

Induction of liver cell haem oxygenase in iron-overloaded rats [PDF]

, 1979
Nader G. Ibrahim, Sylvia Hoffstein, Michael L. Freedman   +2 more
openalex   +1 more source

Immunomodulatory natural polysaccharide‐based nanoparticles for the treatment of neurodegenerative diseases

Ibrain, EarlyView.
Polysaccharide‐based nanoparticles offer versatile platforms for drug delivery and immune modulation in neurodegenerative diseases. This review highlights their potential in treating Alzheimer's, Parkinson's, and multiple sclerosis, focusing on targeted delivery and neuroinflammation.
Leto‐Aikaterini Tziveleka, Mariafrancesca Cascione, Paolo Pellegrino, Annalisa Bianco, Stefano Leporatti, Valeria De Matteis   +5 more
wiley   +1 more source

An improved assay for bacterial methane mono-oxygenase: some properties of the enzyme from Methylomonas methanica [PDF]

, 1975
John Colby, Howard Dalton, R. Whittenbury   +2 more
openalex   +1 more source

Brain Tumor Characterization Using Multiple MR Parameters From Multi‐Contrast EPI With Keyhole (GE‐SE EPIK) Including Oxygen Extraction Fraction: A Comparison to O‐(2‐[18F]Fluoroethyl)‐L‐Tyrosine (FET) Positron Emission Tomography

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Tumor characterization and treatment efficacy are associated with tissue hypoxia. MR‐derived oxygen extraction fraction (OEF) may offer valuable tumor insights but depends on multiple measurement parameters, often requiring multiple sequence acquisitions.
Fabian Küppers, Mohamed Kassem, Seong Dae Yun, Gabriele Stoffels, Christian Filß, Norbert Galldiks, Felix M. Mottaghy, M. Eline Kooi, Karl‐Josef Langen, Philipp Lohmann, N. Jon Shah   +10 more
wiley   +1 more source

Human prolyl hydroxylase domain 2 reacts with O2 and 2-oxoglutarate to enable formation of inactive Fe(III).2OG.hypoxia-inducible-factor α complexes

Scientific Reports
Hypoxia inducible transcription factors (HIFs) mediate the hypoxic response in metazoans. When sufficient O2 is present, Fe(II)/2-oxoglutarate (2OG)-dependent oxygenases (human PHD1-3) promote HIFα degradation via prolyl-hydroxylation.
Giorgia Fiorini, Stephen A. Marshall, William D. Figg, William K. Myers, Lennart Brewitz, Christopher J. Schofield   +5 more
doaj   +1 more source

Hepatocarcinogens induce gene mutations in rats in fibroblast-like cells from a subcutaneous granulation tissue [PDF]

, 2017
Gene-mutations at the 6-thioguanine locus, in fibroblast locus, in fibroblast like-cells rapidly proliferating on the inside of rat subcutaneous air pouches were analysed (Granuloma Pouch Assay).
Maier, P., Schawalder, H.P.
core  

Analysis of Benzoate 1,2‐Dioxygenase Identifies Shared Electron Transfer Components With DxnA1A2 in Rhizorhabdus wittichii RW1

Journal of Basic Microbiology, EarlyView.
ABSTRACT Rhizorhabdus wittichii RW1 is known for its ability to degrade polycyclic aromatic hydrocarbons, such as dibenzo‐p‐dioxin (DD) and dibenzofuran (DF). We hypothesized that the R. wittichii RW1 benzoate 1,2‐dioxygenase shares electron transfer components with the DD/DF angular dioxygenase (DxnA1A2), similar to many aromatic hydrocarbon degrading
Igor Ivanovski, Suha Eleya, Gerben J. Zylstra   +2 more
wiley   +1 more source

Some properties of a soluble methane mono-oxygenase from Methylococcus capsulatus strain Bath [PDF]

, 1976
John Colby, Howard Dalton
openalex   +1 more source

Opuntia ficus‐indica fruit consumption improves insulin resistance in mice with diet‐induced obesity

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Obesity induces various co‐morbidities including insulin resistance. Opuntia ficus‐indica fruit (OFIF) is rich in various beneficial compounds with antioxidant and anti‐inflammatory properties. The present study evaluated the efficacy of OFIF supplementation to counteract obesity‐induced insulin resistance in comparison with an ...
Simona Terzo, Pasquale Calvi, Ignazio Restivo, Alessandro Massaro, Luisa Tesoriere, José‐Manuel Fernández‐Real, Marta Giardina, Antonella Amato, Flavia Mulè, Mario Allegra   +9 more
wiley   +1 more source