Results 211 to 220 of about 63,041 (289)

miR‐138‐5p Inhibits Aortic Valve Interstitial by Targeting SLC39A14 and Activating Nrf2 Signaling

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.
Nrf2 Pathway Inhibition Attenuates miR‐138‐5p's Anti‐Calcification Effects in OM‐Induced hAVICs. A. ALP staining for ALP activity assessment in NC‐mimic, miR‐mimic, and miR‐mimic + ML385 groups. B. Alizarin Red staining for osteogenesis and calcium nIn osteogenic medium‐induced human aortic valve interstitial cells (hAVICs), miR‐138‐5p targets SLC39A14
Fei Yan, Ying Zhao, Yuanyuan Wu, Dubiao Xian, Lei Shi, Yunheng Liang, Ning Wang, Ruiling He, Hongwang Cui, Zhihao Xie   +9 more
wiley   +1 more source

CYP2J2 links metabolic reprogramming to colorectal cancer progression. [PDF]

Arch Med Sci
Lu G, Qiu Y, Liu Z.
europepmc   +1 more source

Individual and Combined Cardioprotective Effects of 1,25(OH)2D3 and Dimethyl Fumarate in an Isoproterenol‐Induced Myocardial Injury Model

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.
1,25(OH)2D3 and dimethyl fumarate, administered alone or in combination, provide significant cardioprotection against isoproterenol‐induced myocardial injury by reducing oxidative stress, inflammation, and structural damage through modulation of the Nrf2/NF‐κB signaling pathways and the renin–angiotensin system (RAS).
Fatma Hande Karpuzoğlu, Serhat Kilinç, İlayda Sözmen, İlknur Bingül, Abdurrahman Fatih Aydin, Aysel Bayram, Semen Önder, Efe Akçe, Semra Doğru‐Abbasoğlu, Müjdat Uysal   +9 more
wiley   +1 more source

Revealing the catalytic mechanism of the Fe(II)/2-oxoglutarate-dependent human epigenetic modifying enzyme ALKBH5. [PDF]

Cell Rep Phys Sci
Cherilakkudy FH, Thomas MG, Varghese A, Waheed SO, Krishnan A, Venditti V, Schofield CJ, Li D, Christov CZ, Karabencheva-Christova TG.   +9 more
europepmc   +1 more source

Deep learning‐assisted design of nanozyme for immune regulation

Journal of Intelligent Medicine, Volume 3, Issue 3, Page 250-276, September 2026.
Overview of nanozyme‐based strategies for inflammatory bowel disease therapy, featuring metal‐based and non‐metallic nanozymes classified by structure, alongside multifunctional and engineered probiotic‐based nanozymes classified by function. Abstract Inflammatory bowel disease (IBD), with rising global incidence and disease burden, is a multifactorial
Ke Chen, Si Sun, Shaofang Zhang, Huanhuan Qiao   +3 more
wiley   +1 more source

A novel and evolutionarily distinct flavoprotein monooxygenase drives skatole degradation in <i>Rhodococcus</i>. [PDF]

Appl Environ Microbiol
Meng N, Li G, Zhang J, Zhu J, Kang X, Duan J, Ma Q.   +6 more
europepmc   +1 more source

Proteo‐Metabolomic Profiling of PMM2‐CDG Reveals Dysregulation of Retinoic Acid Synthesis, Myo‐Inositol, and the Hexosamine Pathway

Journal of Inherited Metabolic Disease, Volume 49, Issue 5, September 2026.
ABSTRACT Phosphomannomutase deficiency (PMM2‐CDG), the most common congenital disorder of glycosylation (CDG), is characterized by multisystem involvement and a lack of disease‐modifying therapies. While previous transcriptomic studies have uncovered disrupted cellular pathways, the functional consequences of these alterations remain poorly understood.
Diana Gallego, Giuseppina Andreotti, Maria Monticelli, Debora Paris, Arturo Martín‐Martínez, Alejandra Gámez, Mercedes Serrano, José Córdoba‐Caballero, Pedro Seoane, Juan A. G. Ranea, Belén Pérez   +10 more
wiley   +1 more source

Combining biocatalytic and radical retrosynthesis for efficient chemoenzymatic synthesis of natural products.

Chem Soc Rev
Renata H.
europepmc   +1 more source

Unlocking microbial potential: advances in omics and bioinformatics for aromatic hydrocarbon degradation. [PDF]

World J Microbiol Biotechnol
Vidal-Silva IM, Loza A, Gutierrez-Rios RM.   +2 more
europepmc   +1 more source

ACE‐inhibitory peptide Leu‐Tyr‐Ala in skeletal muscle actin exhibits anti‐aging effects through the inhibition of acn‐1 in Caenorhabditis elegans

Journal of the Science of Food and Agriculture, Volume 106, Issue 12, Page 7002-7014, September 2026.
Abstract BACKGROUND Inhibitors of angiotensin‐converting enzyme (ACE) are used in pharmaceuticals and functional foods. Captopril, a well‐known ACE inhibitor, extends the lifespan of the nematode Caenorhabditis elegans. Bioactive peptides derived from food sources are considered safe ACE inhibitors.
Issei Yokoyama, Minori Yamane, Kanaho Watanabe, Abdul Fatah, Yusuke Komiya, Jun Nagasao, Keizo Arihara   +6 more
wiley   +1 more source