Results 41 to 50 of about 38,610 (331)
Nature Communications, 2018 Non-heme iron and α-ketoglutarate (αKG) oxygenases play a major role in fungal meroterpenoid biosynthesis, but their mechanism remains elusive. Here the authors present crystal structures of two oxygenases, AusE and PrhA, which provide insights into the ...
Yu Nakashima +7 more
doaj +1 more source
A review about lycopene-induced nuclear hormone receptor signalling in inflammation and lipid metabolism via still unknown endogenous apo-10´-lycopenoids [PDF]
, 2016 Lycopene is the red pigment in tomatoes and tomato products and is an important dietary carotenoid found in the human organism. Lycopene-isomers, oxidative lycopene metabolites and apo-lycopenoids are found in the food matrix.
Aydemir, Gamze +5 more
core +1 more source
Antioxidants, 2020 Stress-inducible heme oxygenase-1 (HO-1) catalyzes the oxidative cleavage of heme yielding biliverdin, ferrous iron, and carbon monoxide (CO). Heme oxygenase activity has been attributed to antioxidant defense via the redox cycling system of biliverdin ...
David Stucki +9 more
doaj +1 more source
Activity In Vitro of Clotrimazole against Canine Methicillin-Resistant and Susceptible Staphylococcus pseudintermedius [PDF]
, 2017 Emergence of multidrug-resistance in Staphylococcus pseudintermedius (SP) has increased interest in topical therapy as an alternative to systemic antibiotics in canine pyoderma.
Bond, R, Frosini, S-M
core +2 more sources
Heme Oxygenase and Atherosclerosis [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2005 Overproduction of reactive oxygen species under pathophysiological conditions, including dyslipidemia, hypertension, diabetes, and smoking, is integral in the development of cardiovascular diseases (CVD). The reactive oxygen species released from all types of vascular cells regulate various signaling pathways that mediate not only vascular inflammation
openaire +3 more sources
Angewandte Chemie, EarlyView.A pangenome analysis of the plant pathogen Pseudomonas syringae reveals two novel natural product families that facilitate niche adaptation. Comprehensive genomic and chemical analyses uncover unique biosynthetic gene clusters linked to host specificity and environmental fitness.
Shuaibing Zhang +7 more
wiley +2 more sources
2-Oxoglutarate derivatives can selectively enhance or inhibit the activity of human oxygenases
Nature Communications, 2021 The human 2-oxoglutarate (2OG) oxygenases FIH and AspH are relevant drug targets. Here, the authors show that synthetic and naturally occurring 2OG derivatives can selectively modulate FIH and AspH activities, suggesting that these compounds may serve as
Yu Nakashima +4 more
doaj +1 more source
Expanding the set of rhodococcal Baeyer–Villiger monooxygenases by high-throughput cloning, expression and substrate screening [PDF]
, 2012 To expand the available set of Baeyer–Villiger monooxygenases (BVMOs), we have created expression constructs for producing 22 Type I BVMOs that are present in the genome of Rhodococcus jostii RHA1.
A Alfieri +38 more
core +4 more sources
Angewandte Chemie, EarlyView.The enantioselective epoxidation of naphthalenes into their corresponding arene oxides with aqueous hydrogen peroxide is described. The reaction combines dearomatization with installation of chemically versatile functionality in an enantioselective manner.
Najoua Choukairi Afailal +2 more
wiley +2 more sources
Oncometabolites: tailoring our genes [PDF]
, 2015 Increased glucose metabolism in cancer cells is a phenomenon that has been known for over 90 years, allowing maximal cell growth through faster ATP production and redistribution of carbons towards nucleotide, protein and fatty acid synthesis.
Avril N, Buck AC, Gimm O, Higashi K
core +1 more source