Results 51 to 60 of about 82,259 (373)

Isolation and characterization of the full-length cDNA encoding a member of a novel cytochrome p450 family (CYP320A1) from the tropical freshwater snail, Biomphalaria glabrata, intermediate host for Schistosoma mansoni [PDF]

, 2005
Cytochrome p450s (cyp450s) are a family of structurally related proteins, with diverse functions, including steroid synthesis and breakdown of toxins. This paper reports the full-length sequence of a novel cyp450 gene, the first to be isolated from the ...
Altschul SF, Anne E Lockyer, Brown DJ, Catherine S Jones, Chang GWM, Chaty S, David Rollinson, Gough J, Leslie R Noble, Lockyer AE, Madera M, Nelson DR, Nelson DR, Omura T, Sambrook J, Snyder MJ, Snyder MJ, Teunissen Y   +17 more
core   +5 more sources

Unleashing the Synthetic Power of Plant Oxygenases: From Mechanism to Application1[OPEN]

Plant Physiology, 2019
The functions and biochemical mechanisms of major classes of plant oxygenases are discussed, and their potential utility for plant synthetic biology is explored.
A. Mitchell, J. Weng
semanticscholar   +1 more source

Endogenous Carbon Monoxide Signaling Modulates Mitochondrial Function and Intracellular Glucose Utilization: Impact of the Heme Oxygenase Substrate Hemin

Antioxidants, 2020
Stress-inducible heme oxygenase-1 (HO-1) catalyzes the oxidative cleavage of heme yielding biliverdin, ferrous iron, and carbon monoxide (CO). Heme oxygenase activity has been attributed to antioxidant defense via the redox cycling system of biliverdin ...
David Stucki, Julia Steinhausen, Philipp Westhoff, Heide Krahl, Dominik Brilhaus, Annika Massenberg, Andreas P. M. Weber, Andreas S. Reichert, Peter Brenneisen, Wilhelm Stahl   +9 more
doaj   +1 more source

Degradation of BTEX by anaerobic bacteria: physiology and application [PDF]

, 2010
Pollution of the environment with aromatic hydrocarbons, such as benzene, toluene, ethylbenzene and xylene (so-called BTEX) is often observed. The cleanup of these toxic compounds has gained much attention in the last decades.
Eekert, M.H.A., van, Stams, A.J.M., Weelink, S.A.B.   +2 more
core   +2 more sources

Characterisation of a Self‐Sufficient Cytochrome P450 Enzyme From the Bacterium Thermosporothrix hazakensis and Its Conversion Into a Peroxygenase

Microbial Biotechnology
The cytochrome P450 monooxygenase enzymes (CYPs) of the CYP102 family are versatile, self‐sufficient biocatalysts. The archetypal example is CYP102A1 (P450BM3) from the bacterium Bacillus (Priestia) megaterium, and variants of this enzyme can oxidise ...
Matthew N. Podgorski, Joel H. Z. Lee, Jarred M. Scaffidi‐Muta, Jinia Akter, Stephen G. Bell   +4 more
doaj   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Cardiac myocyte-specific knock-out of calcium-independent phospholipase A2γ (iPLA2γ) decreases oxidized fatty acids during ischemia/reperfusion and reduces infarct size [PDF]

, 2016
Calcium-independent phospholipase A(2)γ (iPLA(2)γ) is a mitochondrial enzyme that produces lipid second messengers that facilitate opening of the mitochondrial permeability transition pore (mPTP) and contribute to the production of oxidized fatty acids ...
Abendschein, Dana, Gibson Dilthey, Beverly, Gross, Richard W, Guan, Shaoping, Jenkins, Christopher M, Kovacs, Attila, Liu, Xinping, Mancuso, David J, Moon, Sung Ho, Nguyen, Annie L, Sims, Harold F, Weinheimer, Carla J, Yang, Kui   +12 more
core   +2 more sources

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Kidney Organoids in Drug Development: Integrating Technological Advances and Standardization for Effective Implementation

Advanced Healthcare Materials, EarlyView.
This review examines how emerging enabling technologies enhance the physiological relevance, scalability, and reproducibility of kidney organoids, while advanced analytical approaches support model validation and deepen mechanistic insight into nephrotoxicity.
Helen Kearney, Silvia M. Mihăilă, Lorenzo Moroni, Carlos Mota   +3 more
wiley   +1 more source

Characterization and Expression Analysis of Heme Oxygenase Genes from

Bioinformatics and Biology Insights, 2019
Heme oxygenases (HOs) have a major role in phytochrome chromophore biosynthesis, and chromophores in turn have anti-oxidant properties. Plant heme oxygenases are divided into the HO1 sub-family comprising HO1, HO3, and HO4, and the HO2 sub-family, which ...
Takalani Mulaudzi-Masuku, Vivian Ikebudu, Mpho Muthevhuli, Andrew Faro, Christoph A Gehring, Emmanuel Iwuoha   +5 more
doaj   +1 more source