Results 1 to 10 of about 10,487 (100)
Molecular Oncology, 2023 Oxysterols, oxidized derivatives of cholesterol, act in breast cancer (BC) as selective estrogen receptor modulators and affect cholesterol homeostasis, drug transport, nuclear and cell receptors, and other signaling proteins.
Petr Holý +10 more
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Frontiers in Cardiovascular Medicine, 2021 Under hypercholesterolemic conditions, exposure of cells to lipoproteins results in a subtle membrane increase in the levels of cholesterol and 7-ketocholesterol, as compared to normal conditions.
Manuela A.A. Ayee, Irena Levitan
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Data in Brief, 2020 The raw datasets of oxysterol quantifications from whole cell and mitochondrial fractions of THP-1 monocytes and macrophages, neuronal-like SH-SH5Y cells and human peripheral blood mononuclear cells are presented.
Khushboo Borah +6 more
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A quantitative LC-MS/MS method for analysis of mitochondrial -specific oxysterol metabolism
Redox Biology, 2020 Oxysterols are critical regulators of inflammation and cholesterol metabolism in cells. They are oxidation products of cholesterol and may be differentially metabolised in subcellular compartments and in biological fluids.
Khushboo Borah +8 more
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Advancing diagnosis and treatment of Niemann-Pick C disease through biomarker discovery
Exploration of Neuroprotective Therapy, 2021 Niemann-Pick C disease is a rare neurodegenerative, lysosomal storage disease caused by accumulation of unesterified cholesterol. Diagnosis of the disease is often delayed due to its rarity, the heterogeneous presentation, and the early non-specific ...
Xuntian Jiang, Daniel S. Ory
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Cholesterol and HIF-1α: Dangerous Liaisons in Atherosclerosis
Frontiers in Immunology, 2022 HIF-1α exerts both detrimental and beneficial actions in atherosclerosis. While there is evidence that HIF-1α could be pro-atherogenic within the atheromatous plaque, experimental models of atherosclerosis suggest a more complex role that depends on the ...
Charles Thomas +10 more
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Journal of Neuroinflammation, 2018 Background Oxysterols are cholesterol derivatives that have been suggested to play a role in inflammatory diseases such as obesity, atherosclerosis, or neuroinflammatory diseases. However, the effect of neuroinflammation on oxysterol levels has only been
Valentin Mutemberezi +5 more
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Cross-talk between oxysterols and glucocorticoids: differential regulation of secreted phopholipase A2 and impact on oligodendrocyte death. [PDF]
PLoS ONE, 2009 Oxysterols are oxidized forms of cholesterol. They have been shown to be implicated in cholesterol turnover, inflammation and in neurodegenerative diseases such as Alzheimer's disease and multiple sclerosis.
Amalia Trousson +6 more
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A Clickable Oxysterol Photolabel Retains NMDA Receptor Activity and Accumulates in Neurons
Frontiers in Neuroscience, 2018 Oxysterol analogs that modulate NMDA receptor function are candidates for therapeutic development to treat neuropsychiatric disorders. However, the cellular actions of these compounds are still unclear.
Daniel M. Chen +10 more
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The yeast oxysterol binding protein Kes1 maintains sphingolipid levels. [PDF]
PLoS ONE, 2013 The oxysterol binding protein family are amphitropic proteins that bind oxysterols, sterols, and possibly phosphoinositides, in a conserved binding pocket.
Marissa A LeBlanc +6 more
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