Results 141 to 150 of about 7,074 (183)
Some of the next articles are maybe not open access.
Oxysterols and Alzheimer's disease
Acta Neurologica Scandinavica, 2006There is a clear link between cholesterol turnover and neurodegenerative diseases and hypercholesterolemia is an established risk factor for Alzheimer's disease (AD). The failure to demonstrate a transfer of cholesterol from the circulation into the brain in humans and experimental animals makes it difficult to explain the link between ...
Björkhem, I +4 more
openaire +3 more sources
Oxysterols and neurodegenerative diseases
Molecular Aspects of Medicine, 2009In contrast to their parent molecule cholesterol, two of its side-chain oxidized metabolites are able to cross the blood-brain barrier. There is a concentration-driven flux of 24S-hydroxycholesterol (24S-OHC) from the brain into the circulation, which is of major importance for elimination of excess cholesterol from the brain.
Björkhem I +3 more
openaire +2 more sources
Oxysterol biosynthetic enzymes
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2000Oxysterols, herein defined as derivatives of cholesterol with a hydroxyl group on the side chain, play several roles in lipid metabolism. Members of this class regulate the expression of genes that participate in both sterol and fat metabolism, serve as substrates for the synthesis of bile acids, and are intermediates in the transfer of sterols from ...
openaire +2 more sources
Biological activities of oxysterols
Free Radical Biology and Medicine, 1989Literature dealing with the biological activities of cholesterol autoxidation products and related oxysterols in vivo and in vitro published since the previous 1981 monograph is reviewed. Although several oxysterols are important cholesterol metabolites implicated in bile acids and steroid hormones biosynthesis, effects on cellular membranes and on ...
L L, Smith, B H, Johnson
exaly +3 more sources
2018
Oxysterols are oxygenated derivatives of cholesterol formed in the human body or ingested in the diet. By modulating the activity of many proteins (for instance, liver X receptors, oxysterol-binding proteins, some ATP-binding cassette transporters), oxysterols can affect many cellular functions and influence various physiological processes (e.g ...
Fabien, Riols, Justine, Bertrand-Michel
openaire +2 more sources
Oxysterols are oxygenated derivatives of cholesterol formed in the human body or ingested in the diet. By modulating the activity of many proteins (for instance, liver X receptors, oxysterol-binding proteins, some ATP-binding cassette transporters), oxysterols can affect many cellular functions and influence various physiological processes (e.g ...
Fabien, Riols, Justine, Bertrand-Michel
openaire +2 more sources
Future Cardiology, 2009
Oxysterols are biologically active molecules that result from the oxidation of cholesterol. Several oxysterols are found in macrophages and macrophage-derived 'foam cells' in atherosclerotic tissue. Lipophilic oxysterols penetrate cell membranes and, therefore, their concentrations can reach harmful levels in endothelial and smooth muscle cells located
Valeriy, Lukyanenko +1 more
openaire +2 more sources
Oxysterols are biologically active molecules that result from the oxidation of cholesterol. Several oxysterols are found in macrophages and macrophage-derived 'foam cells' in atherosclerotic tissue. Lipophilic oxysterols penetrate cell membranes and, therefore, their concentrations can reach harmful levels in endothelial and smooth muscle cells located
Valeriy, Lukyanenko +1 more
openaire +2 more sources
Analysis of oxysterol metabolomes
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2011Oxysterols are oxygenated forms of cholesterol. This definition can, however, be expanded to include oxygenated derivatives of plant sterols and also of cholesterol precursors. Oxysterols are formed in the first steps of cholesterol metabolism and also from cholesterol by reactive oxygen species. Oxysterols were once thought of as simple intermediates,
William J, Griffiths, Yuqin, Wang
openaire +2 more sources
Oxysterols and nuclear receptors
Molecular and Cellular Endocrinology, 2019Oxysterols are derivatives of cholesterol and an important regulator of cholesterol metabolism, in part due to their role as ligands for nuclear receptors, such as the liver X receptors. Oxysterols are also known to be ligands for the RAR-related orphan receptors, involved in normal T cell differentiation.
Liqian Ma, Erik R. Nelson
openaire +2 more sources
2010
In eukaryotic cells, membranes of the late secretory pathway contain a disproportionally large amount of cholesterol in relation to the endoplasmic reticulum, nuclear envelope and mitochondria. At one extreme, enrichment of the plasma membrane with cholesterol and sphingolipids is crucial for formation of liquid ordered domains (rafts) involved in cell
openaire +2 more sources
In eukaryotic cells, membranes of the late secretory pathway contain a disproportionally large amount of cholesterol in relation to the endoplasmic reticulum, nuclear envelope and mitochondria. At one extreme, enrichment of the plasma membrane with cholesterol and sphingolipids is crucial for formation of liquid ordered domains (rafts) involved in cell
openaire +2 more sources
Biochimie, 2013
I have been involved in research on oxysterols since 1963 and this review is intended to cover some of the most important aspects of this work. The first project dealed with 7α-hydroxy-4-cholesten-3-one. My successful synthesis of this steroid with high specific radioactivity allowed a demonstration that it is a bile acid precursor.
openaire +2 more sources
I have been involved in research on oxysterols since 1963 and this review is intended to cover some of the most important aspects of this work. The first project dealed with 7α-hydroxy-4-cholesten-3-one. My successful synthesis of this steroid with high specific radioactivity allowed a demonstration that it is a bile acid precursor.
openaire +2 more sources