Results 161 to 170 of about 7,256 (187)
Some of the next articles are maybe not open access.
2010
In eukaryotic cells, membranes of the late secretory pathway contain a disproportionally large amount of cholesterol in relation to the endoplasmic reticulum, nuclear envelope and mitochondria. At one extreme, enrichment of the plasma membrane with cholesterol and sphingolipids is crucial for formation of liquid ordered domains (rafts) involved in cell
openaire +2 more sources
In eukaryotic cells, membranes of the late secretory pathway contain a disproportionally large amount of cholesterol in relation to the endoplasmic reticulum, nuclear envelope and mitochondria. At one extreme, enrichment of the plasma membrane with cholesterol and sphingolipids is crucial for formation of liquid ordered domains (rafts) involved in cell
openaire +2 more sources
The effect of oxysterols on nerve impulses
Biochimie, 2018The propagation of nerve impulses in myelinated nerve fibers depends on a number of factors involving the myelin and neural axons. In several neurodegenerative diseases, nerve impulses can be affected by the structural and biochemical characteristics of the myelin sheath and the activity of ion channels located in the nodes of Ranvier.
Bezine, Maryem +14 more
openaire +3 more sources
Interactions of oxysterols with membranes and proteins
Molecular Aspects of Medicine, 2009Oxysterols are oxidized derivatives of cholesterol or by-products of cholesterol biosynthesis with multiple functions. Even though they are heterogeneous in their biological activities, they have the common property of transferring between membranes orders of magnitude faster than cholesterol, due to higher polarity and poorer membrane packing ...
Olkkonen, Vesa M., Hynynen, Riikka
openaire +2 more sources
Oxysterols as biomarkers in neurodegenerative diseases
Chemistry and Physics of Lipids, 2011In the central nervous system cholesterol is involved in membrane structure and function. Since the blood-brain barrier efficiently prevents cholesterol uptake from the circulation, de novo synthesis is responsible for almost all cholesterol present there.
Leoni, V, Caccia, C
openaire +2 more sources
Oxysterols in bile acid metabolism
Clinica Chimica Acta, 2011Increasing body of evidence is available indicating that oxysterols are more much than intermediates of metabolic pathways. Oxysterols play a role in the regulation of cholesterol synthesis, transport and efflux. A scavenger effect of cholesterol 27-hydroxylase on elevated serum cholesterol levels is well demonstrated.
Crosignani, A +3 more
openaire +3 more sources
1987
Studies of the regulation of cholesterol biosynthesis in mammalian cells have led to a model in which transcription of the mRNA for the regulatory enzyme, 3-hydroxy-3-methylglutaryl coenzyme A ((HMG-CoA) reductase, is controlled by an endogenous oxysterol metabolite(s) bound to a specific oxysterol receptor (1,2, Fig 1). Since this regulatory mechanism
Taylor, F R, Kandutsch, A A
openaire +1 more source
Studies of the regulation of cholesterol biosynthesis in mammalian cells have led to a model in which transcription of the mRNA for the regulatory enzyme, 3-hydroxy-3-methylglutaryl coenzyme A ((HMG-CoA) reductase, is controlled by an endogenous oxysterol metabolite(s) bound to a specific oxysterol receptor (1,2, Fig 1). Since this regulatory mechanism
Taylor, F R, Kandutsch, A A
openaire +1 more source
2000
Abstract Cholesterol oxidation products, or oxysterols, are derivatives of cholesterol that have been modified by addition of one or more oxygen functional groups (Table 17.1, Fig. 17.1). Ever since they were first discovered in atherosclerotic lesions more than 50 years ago, controversy has surrounded their role in atherosclerosis.
Malcolm A Lyons, Andrew J Brown
openaire +1 more source
Abstract Cholesterol oxidation products, or oxysterols, are derivatives of cholesterol that have been modified by addition of one or more oxygen functional groups (Table 17.1, Fig. 17.1). Ever since they were first discovered in atherosclerotic lesions more than 50 years ago, controversy has surrounded their role in atherosclerosis.
Malcolm A Lyons, Andrew J Brown
openaire +1 more source
Biochemical and Biophysical Research Communications, 2014
William, Griffiths, Hans, Jörnvall
openaire +4 more sources
William, Griffiths, Hans, Jörnvall
openaire +4 more sources
The Role of Oxysterols in Cholesterol Homeostasis
Nutrition Reviews, 2009Cholesterol biosynthesis is regulated by transcription factors named steroid regulatory element-binding proteins. A newly discovered transcription factor, LXR, regulates the catabolic degradation of cholesterol by activation of the gene controlling cholesterol 7 alpha-hydroxylase, the rate-limiting enzyme in the formation of bile acids.
openaire +2 more sources
Oxysterols and Oxysterol-Binding Proteins in Cellular Lipid Metabolism
2009Oxysterols are 27-carbon oxidized derivatives of cholesterol or by-products of cholesterol synthesis with multiple biological activities. The major oxysterols arise either via cholesterol oxidation by cytochrome P450 enzymes or via non-enzymatic autoxidation processes. Oxysterols are present in healthy tissues or plasma at very low levels but are found
openaire +1 more source