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24S-Hydroxycholesterol: A potential brain-derived biomarker of Huntington’s Disease
Asgari MA +5 more
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Chromatography of oxysterols [PDF]
Biochimie, 2018 Oxysterols play important roles in development and diseases, but can be highly challenging to analyze. To ensure satisfactory measurements, oxysterols must typically be separated with chromatography prior to detection. Here, we will devote attention to the chromatography of oxysterols, focusing on gas chromatography and liquid chromatography.
Irundika H K Dias +2 more
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Oxysterols in Autoimmunity [PDF]
International Journal of Molecular Sciences, 2019 Cholesterol is a member of the sterol family that plays essential roles in biological processes, including cell membrane stability and myelin formation. Cholesterol can be metabolized into several molecules including bile acids, hormones, and oxysterols. Studies from the last few decades have demonstrated that oxysterols are not only active metabolites
Donovan Duc +2 more
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Oxysterols in Infectious Diseases
2023Oxysterols have emerged as important bioactive lipids in the immune response to infectious diseases. This chapter discusses our current knowledge of oxysterols and their receptors in bacterial and viral infections of the respiratory and gastrointestinal tracts.
Foo, Cheng X. +2 more
openaire +4 more sources
Biological activities of oxysterols
Free Radical Biology and Medicine, 1989Literature dealing with the biological activities of cholesterol autoxidation products and related oxysterols in vivo and in vitro published since the previous 1981 monograph is reviewed. Although several oxysterols are important cholesterol metabolites implicated in bile acids and steroid hormones biosynthesis, effects on cellular membranes and on ...
Lee Smith +2 more
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Oxysterols and atherosclerosis
Atherosclerosis, 1999Oxysterols are present in human atherosclerotic plaque and are suggested to play an active role in plaque development. Moreover, the oxysterol:cholesterol ratio in plaque is much higher than in normal tissues or plasma. Oxysterols in plaque are derived both non-enzymically, either from the diet and/or from in vivo oxidation, or (e.g.
A J, Brown, W, Jessup
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Oxysterols and mechanisms of survival signaling [PDF]
Molecular Aspects of Medicine, 2016 Oxysterols, a family of oxidation products of cholesterol, are increasingly drawing attention of scientists to their multifaceted biochemical properties, several of them of clear relevance to human pathophysiology. Taken up by cells through both vesicular and non-vesicular ways or often generated intracellularly, oxysterols contribute to modulate not ...
Gabriella Leonarduzzi +2 more
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Oxysterols and Alzheimer's disease
Acta Neurologica Scandinavica, 2006There is a clear link between cholesterol turnover and neurodegenerative diseases and hypercholesterolemia is an established risk factor for Alzheimer's disease (AD). The failure to demonstrate a transfer of cholesterol from the circulation into the brain in humans and experimental animals makes it difficult to explain the link between ...
Björkhem, I +4 more
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